Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells

Cancer Research

Volumn 61, Issue 15, 2001, Pages 5810-5816

  Dervieux, T ^a   Blanco, J G ^a   Krynetski, E Y ^a   Vanin, E F ^a   Roussel, M F ^a   Relling, M V ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOPURINE; METHOTREXATE; PURINE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG INACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; METHYLATION; PRIORITY JOURNAL; PURINE SYNTHESIS;

3T3 CELLS; 6-MERCAPTOPURINE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOTRANSFORMATION; CYTOSOL; DEOXYGUANOSINE; DNA, NEOPLASM; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; LEUKEMIA, T-CELL, ACUTE; METHYLTRANSFERASES; MICE; PURINE NUCLEOTIDES; PURINES; RETROVIRIDAE; THIOGUANINE; THIONUCLEOSIDES; THIONUCLEOTIDES; TUMOR CELLS, CULTURED;

EID: 0035423158     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Mercaptopurine and related compounds
2. The purine path to chemotherapy
3. Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine
4. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
5. Human RNaseH-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxyguanosine incorporation into DNA
6. Metabolism of thiopyrimidines and thiopurines
7. Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase
8. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
9. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
10. Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
11. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
12. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
13. 6-Mercaptopurine: Cytotoxicity and biochemical pharmacology in human malignant T-lymphoblasts
14. The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts
15. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
16. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
17. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo
18. Production of high-titer helper-free retroviruses by transient transfection
19. High-efficiency transformation of mammalian cells by plasmid DNA
20. Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein
21. High-titer packaging cells producing recombinant retroviruses resistant to human serum
22. Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
23. Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia
24. Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC
25. Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia
26. The effects of inhibitors of DNA biosynthesis on the cytotoxicity of 6-thioguanine
27. Pharmacokineties and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine
28. Human lymphocyte thiopurine methyltransferase pharmacogenetics: Effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation
29. Clinical studies of 6-methylmercaptopurine riboside (NSC-40774) in acute leukemia
30. Biochemical mechanisms for the synergism between 6-Lhioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells
31. 6-Methylthioguanylic acid, a metabolite of 6-thioguanine
32. Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
33. 6-Methylmercaptopurine riboside is a potent and selective inhibitor of nerve growth factor-activated protein kinase N
34. Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process
35. Mercaptopurine vs thioguanine for the treatment of acute lymphoblastic leukemia
36. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
37. Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: Relation to thiopurine metabolism
38. 6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells
39. Unilateral chromatid damage: A new basis for 6-thioguanine cytotoxicity
40. Dissimilar actions of 6-mercaptopurine and 6-thioguanine in Chinese hamster ovary cells
41. The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia
42. Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?