Phenotype determination of thiopurine methyltransferase in erythrocytes by HPLC

Clinical Chemistry

Volumn 47, Issue 5, 2001, Pages 956-958

  Boulieu, R ^a   Sauviat, M ^a   Dervieux, T ^a   Bertocchi, M ^a   Mornex, J F ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE;

ARTICLE; CLINICAL LABORATORY; ENZYME ACTIVITY; ENZYME ASSAY; ERYTHROCYTE; GENETIC POLYMORPHISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PHENOTYPE;

EID: 0035043156     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/47.5.956     Document Type: Article

References (15)

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2. Mercaptopudne pharmacogenetics: Monogenic inheritance of erythrocytes thiopurine methyltransferase activity
3. Pancytopenia related to azathioprine - An enzyme deficiency caused by a common genetic polymorphism: A review
4. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
5. Clinical implications of thiopurine methyltransferase - Optimization of drug dosage and potential drug interactions
6. Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation
7. Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
8. Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with Ioss of TPMT protein and catalytic activity in humans
9. Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population
10. Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
11. High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity
12. Thiopurine methyltransferase activity: New extraction conditions for high-performance liquid chromatographic assay
13. Thiopurine methyltransferase activity in a French population: HPLC assay conditions and effects of drugs and inhibitors
14. Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC
15. Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes