Recent advances in the pharmacogenomics of thiopurine methyltransferase

Pharmacogenomics Journal

Volumn 1, Issue 4, 2001, Pages 254-261

  Coulthard, S A ^a   Hall, A G ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Immunosuppressants; Leukaemia; Pharmacogenomics; Thiopurine; Thiopurine methyltransferase

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; AZATHIOPRINE; MERCAPTOPURINE; METHYLTRANSFERASE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE;

ANIMAL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHARMACOGENETICS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

6-MERCAPTOPURINE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZATHIOPRINE; HUMANS; METHYLTRANSFERASES; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; THIOGUANINE;

EID: 0035755993     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500066     Document Type: Article

References (5)

1. Elalamy I, Lecrubier C, Horellou MH, Conard J, Samama MM. Heparin-induced thrombocytopenia: laboratory diagnosis and management. Ann Med 2000; 32: Suppl 1:60-67.
2. Hobara N, Watanabe A. Impaired metabolism of azathioprine in carbon tetrachloride-injured rats. - Hepatogastroenterology 1981; 28: 192-194.
3. Gunnarsdottir S, Elfarra AA. Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats. I Pharmacol Exp Ther1999; 290: 950-957.
4. Sauer H, Hantke U, Wilmanns W. Azathioprine lymphocytotoxicity. Potentially lethal damage by its imidazole derivatives. Arzneimittelforschung 1988; 38: 820-824.
5. Swann PF, Waters TR, Moulton DC, Xu YZ, Zheng QG, Edwards M, Mace R. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science 1996; 273: 1109-1111.