메뉴 건너뛰기




Volumn 21, Issue 2, 1999, Pages 231-237

Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine

Author keywords

6 Methylmercaptopurine metabolites; 6 Thioguanine nucleotides; Allopurinol; Azathioprine; Glomerulonephritis; Renal transplantation

Indexed keywords

6 METHYLTHIOINOSINE; ALLOPURINOL; AZATHIOPRINE; TIOGUANINE;

EID: 0344286478     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199904000-00015     Document Type: Article
Times cited : (18)

References (32)
  • 1
    • 73649153279 scopus 로고
    • Prolonged survival of human kidney homografts by immunosuppressive drug therapy
    • Murray JE, Merrill JP, Harrison H, et al. Prolonged survival of human kidney homografts by immunosuppressive drug therapy. N Engl J Med 1963;268:1315-23.
    • (1963) N Engl J Med , vol.268 , pp. 1315-1323
    • Murray, J.E.1    Merrill, J.P.2    Harrison, H.3
  • 2
    • 0015829659 scopus 로고
    • Cytostatic treatment of glomerular diseases. Effect of azathioprine on serum creatinine and proteinuna
    • Balsløv JT, Brun C, Birger Jensen K, et al. Cytostatic treatment of glomerular diseases. Effect of azathioprine on serum creatinine and proteinuna. Acta Med Scand 1973;193:483-91.
    • (1973) Acta Med Scand , vol.193 , pp. 483-491
    • Balsløv, J.T.1    Brun, C.2    Birger Jensen, K.3
  • 3
    • 0015318296 scopus 로고
    • Leukopenia and azathioprine management in renal homotransplantation
    • Haesslein HC, Pierce JC, Lee HM, et al. Leukopenia and azathioprine management in renal homotransplantation. Surgery 1972;71: 598-604.
    • (1972) Surgery , vol.71 , pp. 598-604
    • Haesslein, H.C.1    Pierce, J.C.2    Lee, H.M.3
  • 4
    • 0024451147 scopus 로고
    • Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
    • Lennard L, Van Loon JA, Weinshilboum RM. Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989;46: 149-54.
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 149-154
    • Lennard, L.1    Van Loon, J.A.2    Weinshilboum, R.M.3
  • 5
    • 0027401302 scopus 로고
    • Azathiopnne-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
    • Schütz E, Gummert J, Mohr F, et al. Azathiopnne-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993;341:436.
    • (1993) Lancet , vol.341 , pp. 436
    • Schütz, E.1    Gummert, J.2    Mohr, F.3
  • 6
    • 0027173780 scopus 로고
    • Thiopurine methyltransferase activity to asses azathioprine myelotoxicity in renal transplant recipients
    • Soria-Royer C, Legendre C, Mircheva J, et al. Thiopurine methyltransferase activity to asses azathioprine myelotoxicity in renal transplant recipients. Lancet 1993;341:1593-4.
    • (1993) Lancet , vol.341 , pp. 1593-1594
    • Soria-Royer, C.1    Legendre, C.2    Mircheva, J.3
  • 7
    • 0028222607 scopus 로고
    • Day-to-day variability in azathioprine pharmacokinetics in renal transplant recipients
    • Ohlman S, Albertioni F, Peterson C. Day-to-day variability in azathioprine pharmacokinetics in renal transplant recipients. Clin Transplant 1994;8:217-23.
    • (1994) Clin Transplant , vol.8 , pp. 217-223
    • Ohlman, S.1    Albertioni, F.2    Peterson, C.3
  • 8
    • 0029953165 scopus 로고    scopus 로고
    • Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathiopnne?
    • Schütz E, Gummert J, Mohr FW, et al. Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathiopnne? Ther Drug Monit 1996;18:228-33.
    • (1996) Ther Drug Monit , vol.18 , pp. 228-233
    • Schütz, E.1    Gummert, J.2    Mohr, F.W.3
  • 9
    • 26544467159 scopus 로고
    • Immunosuppressive drugs monitoring in renal transplant recipients
    • Krzymański M. Immunosuppressive drugs monitoring in renal transplant recipients. Probl Ther Monit 1993;3:145.
    • (1993) Probl Ther Monit , vol.3 , pp. 145
    • Krzymański, M.1
  • 11
    • 0014171789 scopus 로고
    • Conversion of azathioprine into mercaptopurine and mercaptoimidazole derivatives in vitro and during immunosuppressive therapy
    • Chalmers AH, Knight PR, Atkinson MR. Conversion of azathioprine into mercaptopurine and mercaptoimidazole derivatives in vitro and during immunosuppressive therapy. Aust J Exp Biol Med Sci 1967;45:681-91.
    • (1967) Aust J Exp Biol Med Sci , vol.45 , pp. 681-691
    • Chalmers, A.H.1    Knight, P.R.2    Atkinson, M.R.3
  • 12
    • 0030550014 scopus 로고    scopus 로고
    • Azathioprine conversion to 6-mercaptopurine in quantitative azathioprine determination in plasma
    • Chrzanowska M, Muszalska I. Azathioprine conversion to 6-mercaptopurine in quantitative azathioprine determination in plasma. Chem Anal 1996;41:103-11.
    • (1996) Chem Anal , vol.41 , pp. 103-111
    • Chrzanowska, M.1    Muszalska, I.2
  • 13
    • 0022401174 scopus 로고
    • The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine
    • Van Scoik KG, Johnson CA, Porter WR. The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine. Drug Metab Rev 1985;16:157-74.
    • (1985) Drug Metab Rev , vol.16 , pp. 157-174
    • Van Scoik, K.G.1    Johnson, C.A.2    Porter, W.R.3
  • 14
    • 0016053706 scopus 로고
    • A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson ARP. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 1974; 34:738-46.
    • (1974) Cancer Res , vol.34 , pp. 738-746
    • Tidd, D.M.1    Paterson, A.R.P.2
  • 15
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992;43:329-39.
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 329-339
    • Lennard, L.1
  • 16
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • Lennard L, Van Loon JA, Lilleyman JS, et al. Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 1987;41:18-25.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 18-25
    • Lennard, L.1    Van Loon, J.A.2    Lilleyman, J.S.3
  • 17
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 18
    • 0027419990 scopus 로고
    • Large interindividual variability in bioavailability of azathioprine in renal transplant recipients
    • Ohlman S, Lindholm A, Liliemark J, et al. Large interindividual variability in bioavailability of azathioprine in renal transplant recipients. Clin Transplant 1993;7:65-70.
    • (1993) Clin Transplant , vol.7 , pp. 65-70
    • Ohlman, S.1    Lindholm, A.2    Liliemark, J.3
  • 19
    • 0026717661 scopus 로고
    • The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients
    • Chocair PR, Duley JA, Simmonds HA, et al. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. Transplantation 1992;53:1051-6.
    • (1992) Transplantation , vol.53 , pp. 1051-1056
    • Chocair, P.R.1    Duley, J.A.2    Simmonds, H.A.3
  • 20
    • 0028843101 scopus 로고
    • The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients
    • Snow JL, Gibson LE. The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients. Arch Dermatol 1995;131:193-7.
    • (1995) Arch Dermatol , vol.131 , pp. 193-197
    • Snow, J.L.1    Gibson, L.E.2
  • 21
    • 0023588197 scopus 로고
    • Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells
    • Lennard L. Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells. J Chromatogr 1987;423:169-78.
    • (1987) J Chromatogr , vol.423 , pp. 169-178
    • Lennard, L.1
  • 22
    • 0026465403 scopus 로고
    • High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid, and 6-methylmercaptopurine metabolites in a single sample
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid, and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992;583:83-90.
    • (1992) J Chromatogr , vol.583 , pp. 83-90
    • Lennard, L.1    Singleton, H.J.2
  • 23
    • 0025195675 scopus 로고
    • 6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia
    • Schmiegelow K, Bruunshuus I. 6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia. Cancer Chemother Pharmacol 1990;26:288-92.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 288-292
    • Schmiegelow, K.1    Bruunshuus, I.2
  • 24
    • 0029932094 scopus 로고    scopus 로고
    • Azathioprine pharmacogenetics: The relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation
    • Schütz E, Gummer J, Armstrong VW, et al. Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation. Eur J Clin Chem Clin Biochem 1996;34:199-205.
    • (1996) Eur J Clin Chem Clin Biochem , vol.34 , pp. 199-205
    • Schütz, E.1    Gummer, J.2    Armstrong, V.W.3
  • 25
    • 0021028642 scopus 로고
    • Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopunne and allopurinol
    • Zimm S, Collins JM, O'Neill D, et al. Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopunne and allopurinol. Clin Pharmacol Ther 1983;34:810-17.
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 810-817
    • Zimm, S.1    Collins, J.M.2    O'Neill, D.3
  • 26
    • 0021675990 scopus 로고
    • Azathioprine metabolism in kidney transplant recipients
    • Lennard L, Brown CB, Fox M, et al. Azathioprine metabolism in kidney transplant recipients. Br J Clin Pharmacol 1984;18:693-700.
    • (1984) Br J Clin Pharmacol , vol.18 , pp. 693-700
    • Lennard, L.1    Brown, C.B.2    Fox, M.3
  • 27
    • 0025034447 scopus 로고
    • Azathioprine metabolism: Pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients
    • Chan GL, Erdmann GR, Gruber SA, et al. Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. J Clin Pharmacol 1990;30:358-63.
    • (1990) J Clin Pharmacol , vol.30 , pp. 358-363
    • Chan, G.L.1    Erdmann, G.R.2    Gruber, S.A.3
  • 28
    • 0029790730 scopus 로고    scopus 로고
    • Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism
    • Lennard L, Lilleyman JS. Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism. Ther Drug Monit 1996;18:328-34.
    • (1996) Ther Drug Monit , vol.18 , pp. 328-334
    • Lennard, L.1    Lilleyman, J.S.2
  • 29
    • 0022972626 scopus 로고
    • The effect of food on the oral administration of 6-mercaptopurine
    • Burton NK, Barnett MJ, Aherne GW, et al. The effect of food on the oral administration of 6-mercaptopurine. Cancer Chemother Pharmacol 1986;18:90-1.
    • (1986) Cancer Chemother Pharmacol , vol.18 , pp. 90-91
    • Burton, N.K.1    Barnett, M.J.2    Aherne, G.W.3
  • 30
    • 0030050184 scopus 로고    scopus 로고
    • Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: Pharmacokinetic characteristics
    • Berkovitch M, Matsui D, Zipursky A, et al. Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: Pharmacokinetic characteristics. Med Pediatr Oncol 1996;26:85-9.
    • (1996) Med Pediatr Oncol , vol.26 , pp. 85-89
    • Berkovitch, M.1    Matsui, D.2    Zipursky, A.3
  • 31
    • 0028832238 scopus 로고
    • Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: A possible indicator of non-compliance?
    • Lennard L, Welch J, Lilleyman JS. Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: A possible indicator of non-compliance? Br J Cancer 1995;72:1004-6.
    • (1995) Br J Cancer , vol.72 , pp. 1004-1006
    • Lennard, L.1    Welch, J.2    Lilleyman, J.S.3
  • 32
    • 0029794073 scopus 로고    scopus 로고
    • 6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity
    • Cuffari C, Theoret Y, Latour S, et al. 6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity. Gut 1996;39:401-6.
    • (1996) Gut , vol.39 , pp. 401-406
    • Cuffari, C.1    Theoret, Y.2    Latour, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.