Comprehensive assessment of thiopurine S-methyltransferase (TPMT) alleles in three ethnic populations

Journal of Pediatric Hematology/Oncology

Volumn 24, Issue 5, 2002, Pages 335-336

  Evans, William E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; THIOPURINE METHYLTRANSFERASE;

ALLELISM; ASIA; CHILD; ETHNIC DIFFERENCE; ETHNIC GROUP; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HUMAN; NOTE; POPULATION RESEARCH; POPULATION RISK; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ACUTE DISEASE; ALLELES; ASIA; CHILD; CHILD, PRESCHOOL; ETHNIC GROUPS; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC; METHYLTRANSFERASES; POLYMORPHISM, GENETIC;

EID: 0036065978     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200206000-00002     Document Type: Note

References (25)

1. A survey of thiopurine methyltransferase (TPMT) polymorphisms in a multi-racial Asian population and children with acute lymphoblastic leukemia
2. Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
3. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
4. Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
5. Isolation of a human thiopurine S-methyltransferase (TPMT) cDNA with a singlenucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
6. Genetic analysis of thiopurine methyl transferase polymorphism in a Japanese population
7. Alleotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese
8. Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukaemia
9. The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
10. Thiopurine methyltransferase alleles in British and Ghanaian populations
11. Polymorphism of the thiopurine S-methyltransferase gene in African Americans
12. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
13. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
14. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine
15. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
16. Preponderance of thiopurine Smethyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
17. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
18. Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: Mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C
19. Pharmacogenomics: Unlocking the human genome for better drug therapy
20. Molecular haplotyping of genomic DNA for multiple single nucleotide polymorphisms located kilobases apart, using long-range PCR and intramolecular ligation
21. Linking single nucleotide polymorphisms
22. Pharmacogenomics: Translating functional genomics into rational therapeutics
23. Pharmacogenomics: The inherited basis for interindividual differences in drug response
24. Pharmacogenetics of cancer chemotherapy: Getting personal
25. Pharmacogenomics of childhood acute lymphoblastic leukemia