Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine

Leukemia

Volumn 15, Issue 11, 2001, Pages 1706-1712

  Dervieux, T ^a   Medard Y ^a   Verpillat, P ^b   Guigonis, V ^a   Duval, M ^a   Lescoeur, B ^a   Suciu, S ^c   Vilmer, E ^a   Jacqz Aigrain, E ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b BICHAT HOSPITAL   (France)

^c EORTC DATA CENTER   (Belgium)

Author keywords

6 mercaptopurine; Childhood; Lymphoblastic leukemia; Pharmacogenetics; Thiopurine methyltransferase

Indexed keywords

MERCAPTOPURINE; MERCAPTOPURINE RIBOSIDE; METHOTREXATE; THIOGUANOSINE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CORRELATION FUNCTION; DOSE RESPONSE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME POLYMORPHISM; ERYTHROCYTE LEVEL; FEMALE; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFECTION; LEUKOCYTE COUNT; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MUTANT; PATIENT MONITORING; PRIORITY JOURNAL; STEADY STATE;

EID: 0035166331     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402259     Document Type: Article

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