Regulation of 17-AAG-induced apoptosis: Role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

Blood

Volumn 102, Issue 1, 2003, Pages 269-275

  Nimmanapalli, Ramadevi ^b   O'Bryan, Erica ^b   Kuhn, Deborah ^b   Yamaguchi, Hirohito ^b   Wang, Hong Gang ^b   Bhalla, Kapil N ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINODEMETHOXYGELDANAMYCIN; CASPASE; CASPASE 3; CASPASE 9; CYTOCHROME C; GELDANAMYCIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN SERINE KINASE; RAF PROTEIN; RAF1 PROTEIN; SRC KINASE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

EID: 0037564865     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-12-3718     Document Type: Article

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