Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells

Cancer Research

Volumn 58, Issue 20, 1998, Pages 4561-4566

  Perkins, Charles ^a   Kim, Caryn N ^a   Fang, Guofu ^a   Bhalla, Kapil N ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; PACLITAXEL;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MYELOID LEUKEMIA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; ETOPOSIDE; HL-60 CELLS; HUMANS; PACLITAXEL; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0032532653     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
2. Steller, H. Mechanisms and genes of cellular suicide. Science (Washington DC), 267: 1445-1449, 1995.
3. Hengartner, M. O. Programmed cell death in invertebrates. Curr. Opin. Genet. Dev., 6: 34-38, 1996.
4. Vaux, D. L. CED-4-the third horseman of apoptosis. Cell, 90: 389-390, 1997.
5. Spector, M. S., Desnoyers, S., Hoeppner, D. J., and Hengartner, M. O. Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature (Lond.), 385: 653-656, 1997.
6. Reed, J. C. Double identity for proteins of the Bcl-2 family. Nature (Lond.), 387: 773-776, 1997.
7. Salvesen, G. S., and Dixit, V. M. Caspases: intracellular signaling by proteolysis. Cell, 91: 443-446, 1997.
8. Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J., 326: 1-16, 1997.
9. Hofmann, K., Bucher, P., and Tschopp, J. The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci., 257: 155-156, 1997.
10. Enari, M., Talanian, R. V., Wong, W. W., and Nagala, S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature (Lond.), 380: 723-726, 1996.
11. Muzio, M., Stockwell, B. R., Stennicke, H. R., Salvesen, G. S., and Dixit, V. M. An induced proximity model for caspase-8 activation. J. Biol. Chem., 273: 2926-2930, 1998.
12. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
13. Martin, S. J., and Green, D. R. Protease activation during apoptosis: death by a thousand cuts? Cell, 82: 349-352, 1995.
14. Fraser, A., and Evan, G. A license to kill. Cell, 85: 781-784, 1996.
15. Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Matt, I. L., Camonis, J. H., and Wallach, D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem., 270: 7795-7798, 1995.
16. Chinnaiyan, A. M., O'Rourke, K., Tewari, M., and Dixit, V. M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell, 81: 505-512, 1995.
17. Ahmad, M., Srinivasula, S. M., Wang, L., Talanian, R. V., Litwack, G., Fernandes-Alnemri, T., and Alnemri, E. S. CRADD, a novel human apoptotic adaptor molecule for caspase-2 and Fas/TNF receptor interacting protein RIP. Cancer Res., 57: 615-619, 1997.
18. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participated in cytochrome c-dependent activation of caspase-3. Cell, 90: 405-413, 1997.
19. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489, 1997.
20. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell. 1: 949-957, 1998.
21. L, and Apaf-1 form a ternary complex. J. Biol. Chem., 573: 5841-5845, 1998.
22. L interacts with Apaf-1 and inhibits Apaf-1 dependent caspase-9 activation. Proc. Natl. Acad. Sci. USA, 95: 4386-4391, 1998.
23. Fang, G., Chang, B. S., Kim, C. N., Perkins, C., Thompson, C. B., Bhalla, K. "Loop" domain is necessary for Taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting Taxol-induced cytosolic accumulation of cytochrome c (cyt c) and apoptosis. Cancer Res., 58: 3202-3208, 1998.
24. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T-I., Jones, D. P., and Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
25. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res., 57: 3115-3120, 1997.
26. L Overexpression inhibits taxol-induced Yama protease activity and apoptosis. Cell Growth Differ., 7: 1087-1094, 1996.
27. Deveraux, Q., Takahashi, R., Salveson, G. S., and Reed, J. C. X-linked IAP is a direct inhibitor of cell death proteases. Nature (Lond.), 388: 300-303, 1997.
28. L inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res., 56: 4743-4748, 1996.
29. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147-157, 1996.
30. Ray, S., Ponnathpur, V. Huang, Y., Tang, C., Mahoney, M. E., Ibrado, A. M., Bullock, G., and Bhalla, K. 1-β-D-Arabinofuranosylcytosine-, mitoxantrone- and paclitaxel-induced apoptosis in HL-60 cells: improved method for detection of internucleosomal DNA fragmentation. Cancer Chemother. Pharmacol., 34: 365-371, 1994.
31. Koopman, G., Reutelingsperger, C. P. M., Kuijten, G. A. M., Keehnen, R. M. J., Pals, S. T., and van Oers, M. H. J. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood, 84: 1415-1420, 1994.
32. Kuida, K., Haydar, T. F., Kuan C-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S-S., Rakic, P., and Flavel., R. A. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9. Cell, 94: 325-337, 1998.
33. Haldar, S., Basu, A., and Croce, C. M. Bcl2 is the guardian of microtubule integrity. Cancer Res., 57: 229-233, 1997.
34. Blagosklonny, M. V., Giannakakou, P., El-Deiry, W. S., Kingston, D. G. I., Higgs, P. I., Neckers, L., and Fojo, T. Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res., 57: 130-135, 1997.
35. L Overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human AML HL-60 cells. Cancer Res., 57: 1109-1115, 1997.
36. Deveraux, Q., Roy, N., Stennicke, H. R., Van Arsdale, T., Zhou, Q., Srinivasula, S. M., Alnemri, E. S., Salvesen, G. S., and Reed, J. C. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J., 17: 2215-2223, 1998.
37. L and cytochrome c. Mol. Cell. Biol., 18: 608-615, 1998.