Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells

Leukemia

Volumn 12, Issue 12, 1998, Pages 1930-1936

  Ibrado, A M ^a   Kim, C N ^a   Bhalla, K ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bcl x(L); CDK1; Cyclin B1; Poly (ADP ribose) polymerase

Indexed keywords

CYCLIN DEPENDENT KINASE; CYSTEINE PROTEINASE; CYTOCHROME C; NEOMYCIN; PACLITAXEL;

ANTIBIOTIC RESISTANCE; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOSOL; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MICROTUBULE; MITOCHONDRION; MITOSIS INHIBITION; ONCOGENE; PRIORITY JOURNAL;

EID: 0031762486     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401218     Document Type: Article

References (24)

1. Rowinsky EK, Onetto N, Canetta RM, Arbuck SG. Taxol: the first of the taxanes, an important new class of antitumor agents. Semin Oncol 1992; 19: 646-662.
2. Huizing MT, Sewberath Misser VH, Pieters RC, ten Bokkel Huinink WW, Veenhof CHN, Vermorken JB, Pinedo HM, Beijnen JH. Taxanes: a new class of antitumor agents. Cancer Invest 1995; 13: 381-404.
3. Manfredi JJ, Horwitz SB. Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther 1984; 25: 83-125.
4. Rao S, Orr GA, Chaudhary AG, Kingston DGI; Horwitz SB. Characterization of the Taxol binding site on the microtubule. J Biol Chem 1995; 270: 20235-20238.
5. Jordan MA, Wendell K, Gardiner S, Deny WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of Paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-825.
6. Bhalla K, Ray S, Huang Y, Tang C, Self S, Mahoney ME, Ponnathpur V, Ibrado AM, Bullock G, Willingham MC. Characterization of a human myeloid leukemia cell line highly resistant to taxol. Leukemia 1994; 8: 465-475.
7. cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ 1994; 5: 1041-1050.
8. Morgan DO. Principles of CDK regulation. Nature 1995; 374: 131-134.
9. King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell 1994; 79: 563-571.
10. Graña X, Reddy P. Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995; 11: 211-219.
11. L overexpression inhibits Taxol-induced Yama protease activity and apoptosis. Cell Growth Differ 1996; 7: 1087-1094.
12. Tang C, Willingham MC, Reed JC, Miyashita T, Ray S, Ponnathpur V, Huang Y, Mahoney ME, Bullock G, Bhalla K. High levels of p26Bcl-2 oncoprotein retard Taxol-induced apoptosis in human pre-B leukemia cells. Leukemia 1994; 8: 1960-1969.
13. L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human AML HL-60 cells. Cancer Res 1997; 57: 1109-1115.
14. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996; 86: 147-157.
15. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
16. Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong S-L, Ny SC, Fesik SW. X-ray and NMR structure of human Bel-XL, an inhibitor of programmed cell death. Nature 1996; 381: 335-341.
17. Reed JC. Double identity for proteins of the Bcl-2 family. Nature 1997; 387: 773-776.
18. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
19. cdc2 activation required for apoptosis. Science 1994; 263: 1143-1145.
20. Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 1995; 268: 429-431.
21. Fotedar R, Flatt J, Gupta S, Margolis RL, Fitzgerald P, Messier H, Fotedar A. Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B. Mol Cell Biol 1995; 15: 932-942.
22. Rice WG, Hillyer CD, Harten B, Schaeffer CA, Dorminy M, Lackey DA III, Kirsten E, Mendeleyev J, Buki KG, Hakam A, Kun E. Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly (ADP-ribose) polymerase. Proc Natl Acad Sci USA 1992; 89: 7703-7707.
23. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 1997; 57: 3115-3120.
24. Ray S, Ponnathpur V, Huang Y, Tang C, Mahoney ME, Ibrado AM, Bullock G, Bhalla K. 1-β-D-arabinofuranosylcytosine-, mitoxantrone-, and paclitaxel-induced apoptosis in HL-60 cells: improved method for detection of internucleosomal DNA fragmentation. Cancer Chemother Pharmacol 1994; 34: 365-371.