The functions of thrombospondin-1 and -2

Current Opinion in Cell Biology

Volumn 12, Issue 5, 2000, Pages 634-640

  Lawler, Jack ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; THROMBOSPONDIN; THROMBOSPONDIN 1; THROMBOSPONDIN 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; CELL COMMUNICATION; CELL TYPE; CYTOSKELETON; EXTRACELLULAR MATRIX; GENE ACTIVATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033818794     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00143-5     Document Type: Review

References (45)

1. The thrombospondin type 1 repeat (TSR) super family: Diverse proteins with related roles in neuronal development
2. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density and a bleeding disorder
3. Identification of an alpha(3)beta(1) integrin recognition sequence in thrombospondin-1
4. Transforming growth factor-beta complexes with thrombospondin
5. Activation of latent TGF-beta by thrombospondin-1: Mechanisms and physiology
6. Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1
7. The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-β
8. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia
9. Thrombospondin-1 is a major activator of TGF-β1 in vivo
10. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36
11. Activation of platelet transforming growth factor-beta 1 in the absence of thrombospondin-1
12. The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues
13. Analysis of small latent transforming growth factor-beta complex formation and dissociation by surface plasmon resonance. Absence of direct interaction with thrombospondins
14. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
15. Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity
16. Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
17. Thrombospondin as an inhibitor of angiogenesis
18. Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vasculature
19. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas
20. Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis
21. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential and angiogenesis
22. Inhibition of angiogenesis by thrombospondin-2
23. Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat
24. Inhibition of angiogenesis by thrombospondin-1 is mediated by two independent regions within the type 1 repeats
25. Membrane glycoprotein CD36: A review of its roles in adherence, signal transduction, and transfusion medicine
26. CD36 mediates the in vitro inhibitory effects of thrombospondin-1 on endothelial cells
27. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
28. Protein tyrosine phosphorylation and the adhesive functions of platelets
29. Interaction of recombinant procollagen and properdin modules of thrombospondin-1 with heparin and fibrinogen/fibrin
30. Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type 1 repeats of thrombospondin
31. Role of thrombospondin-1- derived peptide, 4NIK, in FGF-2-induced angiogenisis
32. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
33. Phosphatidylinositol 3-kinase and focal adhesion kinase are early signals in the growth factor-like responses to thrombospondin-1 seen in human vascular smoth muscle
34. Thrombospondin-1 induces activation of focal adhesion kinase in vascular smooth muscle cells
35. Thrombospondin-1 regulation of smooth muscle cell chemotaxis extracellular signal-regulated protein kinases 1/2 dependent
36. Ras N17 transfection inhibits thrombospondin-1-induced vascular smooth muscle cell migration
37. The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells
38. 1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases
39. The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi
40. Cooperation between thrombospondin-1 type 1 repeat peptides and αvβ3 integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation
41. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1
42. Cell-matrix adhesions differentially regulate fascin phosphorylation
43. Thrombospondin signaling of focal adhesion disassembly requires activation of phosphoinositide 3-kinase
44. Muskelin, a novel mediator of cell adhesive and cytoskeletal responses to thrombospondin-1
45. Thrombospondin-1 modulates angiogenesis in vitro by up-regulation of matrix metalloproteinase-9 in endothelial cells