Leptin: From animals to humans

Current Pharmaceutical Design

Volumn 9, Issue 10, 2003, Pages 811-818

  Veniant, Murielle M ^a   LeBel, Carl P ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYL COENZYME A CARBOXYLASE; ADENOSINE PHOSPHATE; CYCLIC AMP; DNA; FATTY ACID; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE; MELANOCORTIN; MESSENGER RNA; NEUROPEPTIDE Y; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; RECOMBINANT LEPTIN; STAT1 PROTEIN; STAT3 PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

APPETITE; BROWN ADIPOSE TISSUE; CLINICAL TRIAL; DIABETES MELLITUS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG MECHANISM; DRUG TOLERABILITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HAIR FOLLICLE; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIPOATROPHIC DIABETES MELLITUS; LIPODYSTROPHY; LIVER; METABOLISM; MUSCLE TISSUE; NERVOUS TISSUE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REVIEW; SEBACEOUS GLAND; SIDE EFFECT; SKELETAL MUSCLE; STEATOSIS; TREATMENT OUTCOME; WHITE ADIPOSE TISSUE;

ANIMALS; DIABETES MELLITUS; HUMANS; LEPTIN; LIVER; MUSCLES; NEURONS; OBESITY;

EID: 0037244307     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612033455369     Document Type: Review

References (96)

1. Pelleymounter, M.A., Cullen, M.J., Baker, M.B. Science, 1995, 269, 5223.
2. Lee, G.H., Proenca, R., Montez, J.M. Nature, 1996, 379(6566), 632.
3. Chehab, F.F., Lim, M.E., Lu, R. Nat. Genet., 1996, (3), 318.
4. Darnell, J.E. Jr. Proc. Natl. Acad. Sci. USA, 1996, 93(13), 6221.
5. Ghilardi, N., Ziegler, S., Wiestner, A. Proc. Natl. Acad. Sci. USA, 1996, 93(13), 6231.
6. Vaisse, C., Halaas, J.L., Horvath, C.M. Nat. Genet., 1996, (1), 95.
7. Bjorbaek, C., Uotani, S., da Silva, B., Flier, J.S. J. Biol. Chem., 1997, 272(51) 32686.
8. Cumin, F., Baum, H.P., Levens, N. Int. J. Obes, Relat. Metab. Disord., 1996, (12), 1120.
9. Banks, W.A., Kastin, A.J., Huang, W. Peptides, 1996, (2), 305.
10. Schwartz, M.W., Seeley, R.J., Campfield, L.A. J. Clin. Invest., 1996, 98(5), 1101.
11. Hamann, A., Matthaei, S. Exp. Clin. Endocrinol. Diabetes, 1996, 104(4), 293.
12. Tartaglia, L.A., Dembski, M., Weng, X. Cell, 1995, 83(7) 1263.
13. Levin, N., Nelson, C., Gurney, A. Proc. Natl. Acad. Sci. USA, 1996, 93(4), 1726.
14. Halaas, J.L., Gajiwala, K.S., Maffei, M. Science, 1995, 269(5223), 543.
15. Campfield, L.A., Smith, F.J., Guisez, Y., Science, 1995, 269(5223) 546, Comment in: Science, 1995, 269(5223) 475.
16. Halaas, J.L., Boozer, C., Blair-West, J. Proc. Natl. Acad. Sci. USA, 1997, 94(16), 8878.
17. Cohen, P., Zhao, C., Cai, X. J. Clin. Invest., 2001, 108(8) 1113.
18. Chen, H., Charlat, O., Tartaglia, L.A. Cell, 1996, 84(3) 491.
19. Elias, C.F., Aschkenasi, S., Lee, C. Neuron, 1999, (4), 775.
20. Spanswick, D., Smith, M.A., Gropp, V.E. Nature, 1997, 390(6659), 521.
21. Lee, K., Dixon, A.K., Richardson, P.J., Pinnock, R.D. J. Physiol., 1999, 515, 439.
22. Cowley, M.A., Smart, J.L., Rubinstein, M. Nature, 2001, 411(6836), 480.
23. Turner, S. M., Linfoot, P. A., Neese, R. A., Hellerstein, M. K. 1998, Diabetes, 47, Suppl. 1. 1081 (abstr.).
24. Rossetti,L., Massillon, D., Barzilai, N. J. Biol. Chem., 1997, 272(44), 27758.
25. Nemecz, M., Preininger, K., Englisch, R. Hepatology, 1999, (1), 166.
26. Ceddia, R.B., Lopes, G., Souza, H.M. Int. J. Obes. Relat. Metab. Disord., 1999, (11), 1207.
27. Liu, L., Karkanias, G.B., Morales, J.C. J. Biol. Chem., 1998, 273(47), 31160.
28. Cohen, B., Novick, D., Rubinstein, M. Science, 1996, 274(5290), 1185.
29. Berti, L., Kellerer, M., Capp, E., Haring, H.U. Diabetologia, 1997, 40(5), 606.
30. Szanto, I., Kahn, C.R. Proc. Natl. Acad. Sci. USA, 2000, 97(5), 2355.
31. Zhao, A.Z., Shinohara, M.M., Huang, D. J. Biol. Chem., 2000, 275(15), 11348.
32. Unger, R.H., Zhou, Y.T., Orci, L. Proc. Natl. Acad. Sci. USA, 1999, 96(5), 2327.
33. Lee, Y., Wang, M.Y., Kakuma, T. J. Biol. Chem., 2001, 276(8), 5629.
34. Luoh, S.M., Di Marco, F., Levin, N. J. Mol. Endocrinol., 1997, (1), 77.
35. Fruhbeck, G., Salvador, J. Diabetologia, 2000, 43(1), 3.
36. Fruhbeck, G., Gomez-Ambros, J., Martinez, J.A. Physiol. Res., 1999, 48(3), 189.
37. Harris, R.B. Biochem. Biophys. Res. Commun., 1998, 245(2), 502.
38. Yaspelkis, B.B. III, Ansari, L., Ramey, E.L. Metabolism, 1999, 48(5), 671.
39. Liu, Y.L., Emilsson, V., Cawthorne, M.A. FEBS Lett., 1997, 411(2-3), 351.
40. Burcelin, R., Kamohara, S., Li J. Diabetes, 1999, 48(6), 1264.
41. Kamohara, S., Burcelin, R., Halaas, J.L. Nature, 1997, 389(6649), 374.
42. Zierath, J.R., Frevert, E.U., Ryder, J.W. Diabetes, 1998, 47(1), 1.
43. Furnsinn, C., Brunmair, B., Furtmuller, R. Diabetologia, 1998, 1(5), 524.
44. Ranganathan, S., Ciaraldi, T.P., Henry, R.R. Endocrinology, 1998, 139(5), 2509.
45. Gong, D.W., He, Y., Karas, M., Reitman, M. J. Biol. Chem., 1997, 272(39), 24129.
46. Pan, D.A., Lillioja, S., Kriketo, A.D. Diabetes, 1997, 46(6), 983.
47. Randle, P.J. Diabetes Metab. Rev., 1998, 14(4), 263.
48. Shimabukuro, M., Koyam, K., Chen, G. Proc. Natl. Acad. Sci. USA, 1997, 94(9), 4637.
49. Chen, G., Koyama, K., Yuan, X., et al. Proc. Natl. Acad. Sci. USA, 1996, 93(25), 14795.
50. Koyama, K., Chen, G., Lee, Y., Unger, R.H. Am. J. Physiol., 1997, 273(4 Pt 1), E708.
51. Muoio, D.M.; Dohm, G.L., Fiedorek, F.T. Jr., Tapscott, E.B., Coleman, R.A., Dohn, G.L. Diabetes, 1997, 46, 1360.
52. Minokoshi, Y., Kim, Y.B., Peroni, O.D. Nature, 2002, 415(6869), 339.
53. Winder, W.W., Hardie, D.G. Am. J. Physiol., 1999, 277, E1.
54. Hardie, D.G., Carling, D., Carlson, M. Ann. Rev. Biochem., 1998, 67, 821.
55. Commins, S.P., Marsh, D.J., Thomas, S.A. Endocrinology, 1999, 140(10) 4772.
56. Commins, S.P., Watson, P.M., Frampton, I.C., Gettys, T.W. Am. J. Physiol. Endocrinol. Metab., 2001, 280(2), E372.
57. Commins, S.P., Watson, P.M., Levin, N., Beiler, R.J., Gettys, T.W. J. Biol. Chem., 2000, 275(42) 33059.
58. Siegrist-Kaiser, C.A., Pauli, V., Juge-Aubry, C.E. J. Clin. Invest., 1997, 100(11) 2858.
59. Kim, Y.B., Uotani, S., Pierroz, D.D. Endocrinology, 2000, 1(7) 2328.
60. Shimabukuro, M., Wang, M.Y., Zhou, Y.T. Proc. Natl. Acad. Sci. USA, 1998, 95(16), 9558.
61. Wang, M.Y., Koyama, K., Shimabukuro, M. Proc. Natl. Acad. Sci. USA, 1998, 95(20), 11921.
62. Wang, M.Y., Koyama, K., Shimabukuro, M. Proc. Natl. Acad. Sci. USA, 1998, 95(2), 714.
63. Karlsson, E., Stridsberg, M., Sandler, S. Biochem. Pharmacol., 1998, 56(10), 1339.
64. Poitout, V., Rouault, C., Guerre-Millo, M. Endocrinology, 1998, 139(3), 822.
65. Fehmann, H.C., Bode, H.P., Ebert, T., Karl, A., Goke, B. Horm. Metab. Res., 1997, 29(11), 572.
66. Ishida, K., Murakami, T., Mizuno, A. Regul. Pept., 1997, 70(2-3) 179.
67. Mizuno, A., Murakami, T., Otani, S. Endocrinology, 1998, 139(9), 3863.
68. Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E., Flier J.S. Mol. Cell, 1998, 1(4), 619.
69. Flier, J.S. J. Clin. Endocrinol. Metab., 1998, 83(5), 1407.
70. Kieffer, T.J., Habener, J.F. Am. J. Physiol. Endocrinol., Metab., 2000, 278(1), E1.
71. Akamatsu, H., Zouboulis, C.C., Orfanos, C.E. J. Invest. Dermatol., 1992, 99(4), 509.
72. Chen, H.C., Smith, S.J., Ladha, Z. J. Clin. Invest., 2002,109(8), 1049.
73. Friedman, J. Nature, 2002, 415, 268.
74. Considine, R.V. Rev. Endocr. Metab. Disord., 2001, 2(4), 357.
75. Ahima, R.S., Flier, J.S. Annu. Rev. Physiol., 2000, 62, 413.
76. Ruhl, C.E. and Everhart, J.E. Am. J. Clin. Nutr., 2001, 74, 295.
77. Considine, R.V., Sinha, M.K., Heiman, M.L N. Engl. J. Med., 1996, 334, 292.
78. Zimmet, P., Hodge, A., Nicolson, M. BMJ, 1996, 313, 965.
79. Geldszus, R., Mayr, B., Horn, R. Eur. J. Endocrinol., 1997, 135, 659.
80. Mavri, A., Stegnar, M. and Sabovic, M. Diab. Obesity Metab., 2001, 3, 293.
81. Kopp, W., Blum, W. F., von Prittwitz, S. Mol. Psychiatry, 1997, 2, 335.
82. Hebebrand, J., Blum, W. F., Barth, N. Mol. Psychiatry, 1997, 2, 330.
83. Caro, J.F., Koaczynski, J.M., Nyce, M.R. Lancet, 1996, 348, 159.
84. Banks, W.A., DiPalma, C.R. and Farrell, C. L. Peptides, 1999, 20, 134.
85. Ahim, R.S., Prabakaran, D., Mantzoros, C. Nature, 1996, 382, 250.
86. Fujioka, K., Patane, J., Lubina, J. JAMA, 1999, 282(16) 1517.
87. Mackintosh, R.M. and Hirsch, J. Obesity Res., 2001, 9(8), 462.
88. Rosenbaum, M., Murphy, E., Heymsfield, S.B. J. Clin. Endocrinol. Metab., 2002, 87(5), 2391.
89. Heymsfield, S.B., Greenberg, A.S., Fujioka, K. JAMA, 1999, 282(16), 1568.
90. Westerterp-Platenga, M.S., Saris, W.H.M., Hukshorn, C.J., and Campfield L.A. Am. J. Clin. Nutr., 2001, 74, 426.
91. Hollander, P., Lewis, G.F., Schwartz, S. Diabetes, 2000, 49 Suppl 1. A359.
92. Farooqi, I.S., Jebb, S.A., Langmack, G. N. Engl. J. Med., 1999, 341(12), 879.
93. Arioglu-Oral, E., Simha, V., Ruiz, E. N. Engl. J. Med., 2002, 346(8), 570.
94. Banks, W. A. Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr. Pharm. Des. 2001, 7(2), 125-33.
95. Wagman, A. S.; Nuss, J. M. Current therapies and emerging targets for the treatment of diabetes. Curr. Pharm. Des. 2001, 7(6), 417-50.
96. Weyer, C.; Maggs, D. G.; Young, A. A.; Kolterman, O. G. Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. Curr. Pharm. Des. 2001, 7(14), 1353-73.