Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin

Journal of Molecular Endocrinology

Volumn 18, Issue 1, 1997, Pages 77-85

  Luoh, S M ^a   Di Marco, F ^a   Levin, N ^a   Armanini, M ^a   Xie, M H ^a   Nelson, C ^a   Bennett, G L ^a   Williams, M ^a   Spencer, S A ^a   Gurney, A ^a   De Sauvage, F J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHALAMUS; MOLECULAR BIOLOGY; MOUSE; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0031044566     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0180077     Document Type: Article

References (22)

1. Aruffo M, Dembic Z & Merlin G 1987 Purification of human gamma interferon receptors by sequential affinity chromotography on immobilized monoclonal antireceptor antibodies and human gamma interferon. Journal of Experimental Medicine 165 988-999.
2. Ashkenazi A & Chamow S 1995 Immunoadhesins: an alternative to human monoclonal antibodies. Methods 8 104-115.
3. Bennett BD, Bennett GL, Vitangcol RV, Jewett JR, Burnier J, Henzel W & Lowe DG 1991 Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. Journal of Biological Chemistry 266 23060-23067.
4. Bray GA & York DA 1979 Hypothalamic and genetic obesity in experimental animals: an autonomie and endocrine hypothesis. Physiological Reviews 59 719-809.
5. Campfield LA, Smith FJ, Guisez Y, Devos R & Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269 546-549.
6. Chen H, Charlat O, Tartaglia L, Woolf E, Weng X, Ellis S, Lakey N, Culpepper J, Moore K, Breitbart R, Duyk G, Tepper R & Morgenstern J 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 491-495.
7. Coleman D 1973 Effect of parabiosis of obese with diabetes and normal mice. Diabetologia 9 294-298.
8. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK & Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 543-546.
9. Heid CA, Stevens J, Livak K, Williams PM 1996 Real time quantitative PCR. Genome Research 6 986-994.
10. Holland PM, Abramson RD, Watson R & Gelfand DH 1991 Detection of specific polymerase chain reaction product by utilizing the 5′-3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proceedings of the National Academy of Sciences of the USA 88 7276-7280.
11. Hulsey MG & Martin RJ 1992 An anorectic agent from adipose tissue of overfed rats: effects on feeding behavior. Physiology and Behaviour 52 1141-1149.
12. Lee G-W, Proenca R, Montez J, Carroll K, Darvishzadeh J, Lee J & Friedman J 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 632-635.
13. Lee LG, Connell CR & Bloch W 1993 Allelic discrimination by nick-translation PCR with fluorogenic probes. Nucleic Acids Research 21 3761-3766.
14. Levin N, Nelson C, Gurney A, Vandlen R & de Sauvage F 1996 Dissociation of adiposity reduction from food intake decreases after ob protein infusions. Proceedings of the National Academy of Sciences of the USA 93 1726-1730.
15. Maffei M, Fei H, Lee GH, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G & Friedman JM 1995 Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proceedings of the National Academy of Sciences of the USA 92 6957-6960.
16. Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K & Green MR 1984 Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research 12 7035-7052.
17. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T & Kishimoto T 1991 Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proceedings of the National Academy of Sciences of the USA 88 11349-11353.
18. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T & Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 540-543.
19. Phillips HS, Hains JM, Laramee GR, Rosenthal A & Winslow JW 1990 Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science 250 290-294.
20. Stephens TW, Basinski M, Bristow PK, Bue Valkeskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, Mackellar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang X-Y & Heiman M 1995 The role of neuropeptide Y in the anti-obesity action of the obese gene product. Nature 377 530-532.
21. Tartaglia L, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards G, Campfield L, Clark F, Deeds J, Muir C, Sanker S, Moriarty A, Moore K, Smutko J, Mays G, Woolf E, Monroe C & Tepper R 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83 1263-1271.
22. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432.