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Volumn 33, Issue 5, 1997, Pages 703-709

The biology of replicative senescence

Author keywords

ageing; cancer; replicative senescence; somatic cells; tumour suppression

Indexed keywords

CANCER INHIBITION; CARCINOGENESIS; CELL AGING; CELL DIVISION; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; TELOMERE;

EID: 0030964277     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(96)00058-5     Document Type: Article
Times cited : (440)

References (79)
  • 1
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37, 614-636.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 2
    • 0023276258 scopus 로고
    • Cellular senescence revisited: A review
    • Stanulis-Praeger B. Cellular senescence revisited: a review. Mech Ageing Dev 1987, 38, 1-48.
    • (1987) Mech Ageing Dev , vol.38 , pp. 1-48
    • Stanulis-Praeger, B.1
  • 3
    • 0000962421 scopus 로고    scopus 로고
    • Control of replicative senescence
    • Schneider E, Rowe J, eds. New York, Academic Press
    • Campisi J, Dimri GP, Hara E. Control of replicative senescence. In Schneider E, Rowe J, eds. Handbook of the Biology of Aging. New York, Academic Press, 1996, 121-149.
    • (1996) Handbook of the Biology of Aging , pp. 121-149
    • Campisi, J.1    Dimri, G.P.2    Hara, E.3
  • 4
    • 0030025660 scopus 로고    scopus 로고
    • Replicative senescence: An old lives tale?
    • Campisi J. Replicative senescence: an old lives tale? Cell 1996, 84, 497-500.
    • (1996) Cell , vol.84 , pp. 497-500
    • Campisi, J.1
  • 5
    • 0027755545 scopus 로고
    • The genetics of aging in the yeast saccharomyces cerevisiae
    • Jazwinski SM. The genetics of aging in the yeast Saccharomyces cerevisiae. Genetica 1993, 91, 35-51.
    • (1993) Genetica , vol.91 , pp. 35-51
    • Jazwinski, S.M.1
  • 6
    • 0026006294 scopus 로고
    • Senescence as a mode of tumor suppression
    • Sager R. Senescence as a mode of tumor suppression. Environ Health Persp 1991, 93, 59-62.
    • (1991) Environ Health Persp , vol.93 , pp. 59-62
    • Sager, R.1
  • 7
    • 0023898298 scopus 로고
    • Towards an understanding of the malignant transformation of diploid human fibroblasts
    • McCormick JJ, Maher VM. Towards an understanding of the malignant transformation of diploid human fibroblasts. Mutat Res 1988, 199, 273-291.
    • (1988) Mutat Res , vol.199 , pp. 273-291
    • McCormick, J.J.1    Maher, V.M.2
  • 8
    • 0025729836 scopus 로고
    • Defining the molecular mechanisms of human cell immortalization
    • Shay JW, Wright WE. Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1991, 1071, 1-7.
    • (1991) Biochim Biophys Acta , vol.1071 , pp. 1-7
    • Shay, J.W.1    Wright, W.E.2
  • 9
    • 0020610446 scopus 로고
    • Evidence for the recessive nature of cellular immortality
    • Pereira-Smith OM, Smith JR. Evidence for the recessive nature of cellular immortality. Science 1983, 221, 964-967.
    • (1983) Science , vol.221 , pp. 964-967
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 10
    • 0011208723 scopus 로고
    • Genetic analysis of indefinite division in human cells: Identification of four complementation groups
    • Pereira-Smith OM, Smith JR. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc Natl Acad Sci USA 1988, 85, 6042-6046.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6042-6046
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 11
    • 0025953702 scopus 로고
    • Genetic analysis of indefinite division in human cells: Evidence for a senescence-related gene(s) on human chromosome 4
    • King Y, Weber JL, Killary AM, Ledbetter DH, Smith JR, Pereira-Smith OM. Genetic analysis of indefinite division in human cells: evidence for a senescence-related gene(s) on human chromosome 4. Proc Natl Acad Sci USA 1991, 88, 5635-5639.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5635-5639
    • King, Y.1    Weber, J.L.2    Killary, A.M.3    Ledbetter, D.H.4    Smith, J.R.5    Pereira-Smith, O.M.6
  • 12
    • 0028294621 scopus 로고
    • A gene involved in control of human cellular senescence on human chromosome 1q
    • Hensler P, Annab LA, Barrett JC, Pereira-Smith OM. A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol 1994, 14, 2292-2297.
    • (1994) Mol Cell Biol , vol.14 , pp. 2292-2297
    • Hensler, P.1    Annab, L.A.2    Barrett, J.C.3    Pereira-Smith, O.M.4
  • 13
    • 0027382325 scopus 로고
    • Chromosome 7 suppresses indefinite division of non-tumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1
    • Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M. Chromosome 7 suppresses indefinite division of non-tumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol 1993, 13, 6036-6043.
    • (1993) Mol Cell Biol , vol.13 , pp. 6036-6043
    • Ogata, T.1    Ayusawa, D.2    Namba, M.3    Takahashi, E.4    Oshimura, M.5    Oishi, M.6
  • 14
    • 0025145238 scopus 로고
    • Replicative senescence: The human fibroblast comes of age
    • Goldstein S. Replicative senescence: the human fibroblast comes of age. Science 1990, 249, 1129-1133.
    • (1990) Science , vol.249 , pp. 1129-1133
    • Goldstein, S.1
  • 15
    • 0001111837 scopus 로고
    • Expression of cell cycle dependent genes in young and senescent WI38 fibroblasts
    • Rittling SR, Brooks KM, Cristofalo VJ, Baserga R. Expression of cell cycle dependent genes in young and senescent WI38 fibroblasts. Proc Natl Acad Sci USA 1986, 83, 3316-3320.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3316-3320
    • Rittling, S.R.1    Brooks, K.M.2    Cristofalo, V.J.3    Baserga, R.4
  • 16
    • 0025052004 scopus 로고
    • C-fos repression and an altered genetic program in senescent human fibroblasts
    • Seshadri T, Campisi J. c-fos repression and an altered genetic program in senescent human fibroblasts. Science 1990, 247, 205-209.
    • (1990) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 17
    • 0027976669 scopus 로고
    • Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
    • Hara E, Yamaguchi T, Nojima H, et al. Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J Biol Chem 1994, 269, 2139-2145.
    • (1994) J Biol Chem , vol.269 , pp. 2139-2145
    • Hara, E.1    Yamaguchi, T.2    Nojima, H.3
  • 18
    • 0028361374 scopus 로고
    • Regulation of two E2F related genes in presenescent and senescent human fibroblasts
    • Dimri GP, Hara E, Campisi J. Regulation of two E2F related genes in presenescent and senescent human fibroblasts. J Biol Chem 1994, 269, 16180-16186.
    • (1994) J Biol Chem , vol.269 , pp. 16180-16186
    • Dimri, G.P.1    Hara, E.2    Campisi, J.3
  • 19
    • 0029763526 scopus 로고    scopus 로고
    • Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence
    • Good LF, Dimri GP, Campisi J, Chen KY. Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J Cell Physiol 1996, 168, 580-588.
    • (1996) J Cell Physiol , vol.168 , pp. 580-588
    • Good, L.F.1    Dimri, G.P.2    Campisi, J.3    Chen, K.Y.4
  • 20
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein GH, Beeson M, Gordon L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 1990, 249, 666-669.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 21
    • 0028342664 scopus 로고
    • Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen
    • Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994, 211, 90-98.
    • (1994) Exp Cell Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 22
    • 0029670840 scopus 로고    scopus 로고
    • Regulation of p16 (CdkN2) expression and its implications for cell immortalization and senescence
    • Hara E, Smith R, Parry D, Tahara H, Peters G. Regulation of p16 (CdkN2) expression and its implications for cell immortalization and senescence. Mol Cell Biol 1996, 16, 859-867.
    • (1996) Mol Cell Biol , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3    Tahara, H.4    Peters, G.5
  • 23
    • 0027332123 scopus 로고
    • Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-cdk and cyclin D-cdk complexes
    • Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-cdk and cyclin D-cdk complexes. Proc Natl Acad Sci USA 1993, 90, 11034-11038.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11034-11038
    • Dulic, V.1    Drullinger, L.F.2    Lees, E.3    Reed, S.I.4    Stein, G.H.5
  • 24
    • 0030003153 scopus 로고    scopus 로고
    • Inhibition of E2F activity by the p21 inhibitor of cyclin-dependent protein kinases in cells expressing or lacking a functional retinoblastoma protein
    • Dimri GP, Nakanishi M, Desprez PY, Smith JR, Campisi J. Inhibition of E2F activity by the p21 inhibitor of cyclin-dependent protein kinases in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol 1996, 16, 2987-2997.
    • (1996) Mol Cell Biol , vol.16 , pp. 2987-2997
    • Dimri, G.P.1    Nakanishi, M.2    Desprez, P.Y.3    Smith, J.R.4    Campisi, J.5
  • 25
    • 0029917511 scopus 로고    scopus 로고
    • The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts
    • Hara E, Uzman JA, Dimri GP, Nehlin JO, Testori A, Campisi J. The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. Dev Genetics 1996, 18, 161-172.
    • (1996) Dev Genetics , vol.18 , pp. 161-172
    • Hara, E.1    Uzman, J.A.2    Dimri, G.P.3    Nehlin, J.O.4    Testori, A.5    Campisi, J.6
  • 26
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death and failure to suppress bcl2 is involved
    • Wang E. Senescent human fibroblasts resist programmed cell death and failure to suppress bcl2 is involved. Cancer Res 1995, 55, 2284-2292.
    • (1995) Cancer Res , vol.55 , pp. 2284-2292
    • Wang, E.1
  • 28
    • 0025186452 scopus 로고
    • Extension of the life-span of human endothelial cells by an interleukin-1x anti-sense oligomer
    • Maier JAM, Voulalas P, Roeder D, Maciag T. Extension of the life-span of human endothelial cells by an interleukin-1x anti-sense oligomer. Science 1990, 249, 1570-1574.
    • (1990) Science , vol.249 , pp. 1570-1574
    • Maier, J.A.M.1    Voulalas, P.2    Roeder, D.3    Maciag, T.4
  • 29
    • 0027194495 scopus 로고
    • Senescence stimulates U037-endothelial cell interactions
    • Maier JAM, Statuto M, Ragnoti G. Senescence stimulates U037-endothelial cell interactions. Exp Cell Res 1993, 208, 270-274.
    • (1993) Exp Cell Res , vol.208 , pp. 270-274
    • Maier, J.A.M.1    Statuto, M.2    Ragnoti, G.3
  • 30
    • 0028147929 scopus 로고
    • Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells
    • Swisshelm K, Ryan K, Lee X, Tsou H, Peacocke M, Sager R. Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Diff 1994, 5, 133-141.
    • (1994) Cell Growth Diff , vol.5 , pp. 133-141
    • Swisshelm, K.1    Ryan, K.2    Lee, X.3    Tsou, H.4    Peacocke, M.5    Sager, R.6
  • 31
    • 0024445960 scopus 로고
    • Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity
    • West MD, Pereira-Smith OM, Smith JR. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp Cell Res 1989, 184, 138-137.
    • (1989) Exp Cell Res , vol.184 , pp. 138-1137
    • West, M.D.1    Pereira-Smith, O.M.2    Smith, J.R.3
  • 32
    • 0026793281 scopus 로고
    • Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts
    • Millis AJ, Hoyle M, McCue HM, Martini H. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp Cell Res 1992, 201, 373-379.
    • (1992) Exp Cell Res , vol.201 , pp. 373-379
    • Millis, A.J.1    Hoyle, M.2    McCue, H.M.3    Martini, H.4
  • 33
    • 0028304454 scopus 로고
    • A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during g1 progression, mitogenic stimulation, differentiation and senescence
    • Wick M, Burger C, Brusselbach S, Lucibello FC, Muller R. A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation and senescence. J Biol Chem 1994, 269, 18953-18960.
    • (1994) J Biol Chem , vol.269 , pp. 18953-18960
    • Wick, M.1    Burger, C.2    Brusselbach, S.3    Lucibello, F.C.4    Muller, R.5
  • 35
    • 0029047362 scopus 로고
    • A novel biomarker identifies senescent human cells in culture and aging skin in vivo
    • Dimri GP, Lee X, Basile G, et al. A novel biomarker identifies senescent human cells in culture and aging skin in vivo. Proc Natl Acad Sci USA 1995, 92, 9363-9367.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 36
    • 0030887851 scopus 로고    scopus 로고
    • Aging and cancer: The double-edged sword of replicative senescence
    • Campisi J. Aging and cancer: the double-edged sword of replicative senescence. J Am Geriatrics Soc 1997, 45, 1-6.
    • (1997) J Am Geriatrics Soc , vol.45 , pp. 1-6
    • Campisi, J.1
  • 37
    • 0028958708 scopus 로고
    • Telomeres and telomerase in aging and cancer
    • Harley CB, Villeponteau B. Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev 1995, 5, 249-255.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 249-255
    • Harley, C.B.1    Villeponteau, B.2
  • 38
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1
    • Hara E, Tsuri H, Shinozaki S, Oda K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1. Biochem Biophys Res Comm 1991, 179, 528-534.
    • (1991) Biochem Biophys Res Comm , vol.179 , pp. 528-534
    • Hara, E.1    Tsuri, H.2    Shinozaki, S.3    Oda, K.4
  • 39
    • 0027263711 scopus 로고
    • E6 of human papillomavirus type-16 can overcome the M1 stage immortalization in human mammary epithelial cells but not in human fibroblasts
    • Shay JW, Wright WE, Brasiskyte D, Vanderhaegen BA. E6 of human papillomavirus type-16 can overcome the M1 stage immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 1993, 8, 1407-1413.
    • (1993) Oncogene , vol.8 , pp. 1407-1413
    • Shay, J.W.1    Wright, W.E.2    Brasiskyte, D.3    Vanderhaegen, B.A.4
  • 40
    • 0029005279 scopus 로고
    • Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7
    • Wazer DE, Liu XL, Chu Q, Gao Q, Band V. Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. Proc Natl Acad Sci USA 1995, 92, 3687-3691.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3687-3691
    • Wazer, D.E.1    Liu, X.L.2    Chu, Q.3    Gao, Q.4    Band, V.5
  • 43
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn EH. Structure and function of telomeres. Nature 1991, 350, 569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 45
    • 0024362809 scopus 로고
    • Human telomeres contain at least three types of G-rich repeat distributed non-randomly
    • Allshire RC, Dempster M, Hastie ND. Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res 1989, 17, 4611-4627.
    • (1989) Nucleic Acids Res , vol.17 , pp. 4611-4627
    • Allshire, R.C.1    Dempster, M.2    Hastie, N.D.3
  • 46
    • 0025279931 scopus 로고
    • Telomeres shorten during aging of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during aging of human fibroblasts. Nature 1990, 345, 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 49
    • 0026460896 scopus 로고
    • Telomere length predicts replicative capacity of human fibroblasts
    • Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992, 89, 10114-10118.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10114-10118
    • Allsopp, R.C.1    Vaziri, H.2    Patterson, C.3
  • 50
    • 0029145379 scopus 로고
    • Evidence for a critical telomere length in senescent human fibroblasts
    • Allsopp RC, Harley CB. Evidence for a critical telomere length in senescent human fibroblasts. Exp Cell Res 1995, 219, 130-136.
    • (1995) Exp Cell Res , vol.219 , pp. 130-136
    • Allsopp, R.C.1    Harley, C.B.2
  • 51
    • 0030004489 scopus 로고    scopus 로고
    • Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids
    • Wright WE, Brasiskyte D, Piatyszek M, Shay JW. Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. EMBO J 1996, 15, 1734-1741.
    • (1996) EMBO J , vol.15 , pp. 1734-1741
    • Wright, W.E.1    Brasiskyte, D.2    Piatyszek, M.3    Shay, J.W.4
  • 52
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 226, 2011-2015.
    • (1994) Science , vol.226 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 53
    • 0028938262 scopus 로고
    • Telomerase activity in normal leukocytes and in hematologic malignancies
    • Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995, 85, 2315-2320.
    • (1995) Blood , vol.85 , pp. 2315-2320
    • Counter, C.M.1    Gupta, J.2    Harley, C.B.3    Leber, B.4    Bacchetti, S.5
  • 54
    • 0029091386 scopus 로고
    • Telomerase activity in human peripheral blood and bone marrow cells
    • Hiyama K, Hirai Y, Kyoisumi S, et al. Telomerase activity in human peripheral blood and bone marrow cells. J Immunol 1995, 155, 3711-3715.
    • (1995) J Immunol , vol.155 , pp. 3711-3715
    • Hiyama, K.1    Hirai, Y.2    Kyoisumi, S.3
  • 55
    • 0028858814 scopus 로고
    • Telomere length and proliferation potential of hematopoietic stem cells
    • Landsdorp PM. Telomere length and proliferation potential of hematopoietic stem cells. J Cell Sci 1995, 108, 1-6.
    • (1995) J Cell Sci , vol.108 , pp. 1-6
    • Landsdorp, P.M.1
  • 56
    • 0029040101 scopus 로고
    • Development and tissue specific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW. Development and tissue specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci USA 1995, 92, 4818-4822.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 57
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli D, Young JW, DeLange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 1995, 93, 9083-9086.
    • (1995) Proc Natl Acad Sci USA , vol.93 , pp. 9083-9086
    • Broccoli, D.1    Young, J.W.2    Delange, T.3
  • 59
    • 0027486732 scopus 로고
    • Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
    • Vaziri H, Schachter F, Uchida I, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993, 52, 661-667.
    • (1993) Am J Hum Genet , vol.52 , pp. 661-667
    • Vaziri, H.1    Schachter, F.2    Uchida, I.3
  • 60
    • 0029810884 scopus 로고    scopus 로고
    • Telomerase regulation during entry into the cell cycle in normal human T cells
    • Buchkovich KJ, Greider CW. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Cell Biol 1996, 7, 1443-1454.
    • (1996) Mol Cell Biol , vol.7 , pp. 1443-1454
    • Buchkovich, K.J.1    Greider, C.W.2
  • 61
    • 0029877250 scopus 로고    scopus 로고
    • Insights on immunological aging derived from the T lymphocyte cellular senescence model
    • Effros RB. Insights on immunological aging derived from the T lymphocyte cellular senescence model. Exp Gerontol 1996, 31, 21-27.
    • (1996) Exp Gerontol , vol.31 , pp. 21-27
    • Effros, R.B.1
  • 62
    • 0029894199 scopus 로고    scopus 로고
    • Regulated expression of telomerase activity in human T lymphocyte development and activation
    • Weng NP, Levine BL, June CH, Hodes RJ. Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 1996, 183, 2471-2479.
    • (1996) J Exp Med , vol.183 , pp. 2471-2479
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 63
    • 0029901910 scopus 로고    scopus 로고
    • Telomerase activity in the regenerative basal layer of the epidermis in human skin and immortal and carcinoma-derived skin keratinocytes
    • Harlebachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci 1996, 93, 6476-6481.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 6476-6481
    • Harlebachor, C.1    Boukamp, P.2
  • 64
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995, 14, 4240-4248.
    • (1995) EMBO J , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 65
    • 0029655485 scopus 로고    scopus 로고
    • Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
    • Strahl C, Blackburn EH. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol 1996, 16, 53-65.
    • (1996) Mol Cell Biol , vol.16 , pp. 53-65
    • Strahl, C.1    Blackburn, E.H.2
  • 66
    • 0028981143 scopus 로고
    • Time, telomeres and tumours: Is cellular senescence more than an anticancer mechanism?
    • Wright WE, Shay JW. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism? Trends Cell Biol 1995, 5, 293-297.
    • (1995) Trends Cell Biol , vol.5 , pp. 293-297
    • Wright, W.E.1    Shay, J.W.2
  • 67
    • 0027421043 scopus 로고
    • Loss of a yeast telomere: Arrest, recovery and chromosome loss
    • Sandell LL, Zakian VA. Loss of a yeast telomere: arrest, recovery and chromosome loss. Cell 1993, 75, 729-739.
    • (1993) Cell , vol.75 , pp. 729-739
    • Sandell, L.L.1    Zakian, V.A.2
  • 69
    • 0028898823 scopus 로고
    • Regulation of c-fos in senescing werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors
    • Oshima J, Campisi J, Tannock CA, Martin GM. Regulation of c-fos in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol 1995, 162, 277-283.
    • (1995) J Cell Physiol , vol.162 , pp. 277-283
    • Oshima, J.1    Campisi, J.2    Tannock, C.A.3    Martin, G.M.4
  • 70
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
    • Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol 1989, 9, 3088-3092.
    • (1989) Mol Cell Biol , vol.9 , pp. 3088-3092
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.W.3
  • 71
    • 0024400975 scopus 로고
    • Growth of immortal simian virus 40 ts-A transformed human fibroblasts is temperature dependent
    • Radna RL, Caton Y, Jha KK, et al. Growth of immortal simian virus 40 ts-A transformed human fibroblasts is temperature dependent. Mol Cell Biol 1989, 9, 3093-3096.
    • (1989) Mol Cell Biol , vol.9 , pp. 3093-3096
    • Radna, R.L.1    Caton, Y.2    Jha, K.K.3
  • 72
    • 0029741576 scopus 로고    scopus 로고
    • Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein
    • Marcand S, Buck SW, Moretti P, Gilson E, Shore D. Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes Dev 1996, 10, 1297-1309.
    • (1996) Genes Dev , vol.10 , pp. 1297-1309
    • Marcand, S.1    Buck, S.W.2    Moretti, P.3    Gilson, E.4    Shore, D.5
  • 73
    • 0028876255 scopus 로고
    • You haven't heard the end of it: Telomere loss may link human aging with cancer
    • Shay JW, Werbin H, Wright WE. You haven't heard the end of it: telomere loss may link human aging with cancer. Can J Aging 1995, 14, 511-524.
    • (1995) Can J Aging , vol.14 , pp. 511-524
    • Shay, J.W.1    Werbin, H.2    Wright, W.E.3
  • 74
    • 0026682717 scopus 로고
    • Telomere positional effects and the regulation of cellular senescence
    • Wright WE, Shay JW. Telomere positional effects and the regulation of cellular senescence. Trends Genet 1992, 8, 193-197.
    • (1992) Trends Genet , vol.8 , pp. 193-197
    • Wright, W.E.1    Shay, J.W.2
  • 75
    • 0026443594 scopus 로고
    • Silencers, silencing and heritable transcriptional states
    • Laurenson P, Rine J. Silencers, silencing and heritable transcriptional states. Microbiol Rev 1992, 56, 543-560.
    • (1992) Microbiol Rev , vol.56 , pp. 543-560
    • Laurenson, P.1    Rine, J.2
  • 76
    • 0002539276 scopus 로고
    • Telomere position effect and transcriptional silencing in the yeast Saccharomyces cerevisiae
    • Blackburn EH, Greider CW, eds. Cold Spring Harbor Press
    • Shore D. Telomere position effect and transcriptional silencing in the yeast Saccharomyces cerevisiae. In Blackburn EH, Greider CW, eds. Telomeres. Cold Spring Harbor Press, 1995, 247-263.
    • (1995) Telomeres , pp. 247-263
    • Shore, D.1
  • 77
    • 0029778901 scopus 로고    scopus 로고
    • Human fibroblast commitment to a senescence-like state in responses to histone deacetylase inhibitors is cell cycle dependent
    • Ogryzko VV, Harai TH, Russanova VR, Barbie DA, Howard BH. Human fibroblast commitment to a senescence-like state in responses to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol 1996, 16, 5210-5218.
    • (1996) Mol Cell Biol , vol.16 , pp. 5210-5218
    • Ogryzko, V.V.1    Harai, T.H.2    Russanova, V.R.3    Barbie, D.A.4    Howard, B.H.5
  • 78
    • 0029987121 scopus 로고    scopus 로고
    • Effect of replicative age on transcriptional silencing near telomeres in saccharomyces cerevisiae
    • Kim S, Villeponteau B, Jazwinski SM. Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae. Biochem Biophys Res Comm 1996, 219, 370-376.
    • (1996) Biochem Biophys Res Comm , vol.219 , pp. 370-376
    • Kim, S.1    Villeponteau, B.2    Jazwinski, S.M.3
  • 79
    • 0030053650 scopus 로고    scopus 로고
    • Loss of transcriptional silencing causes sterility in old mother cells of S. Cerevisiae
    • Smeal T, Claus J, Kennedy B, Cole F, Guarente L. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 1996, 84, 633-642.
    • (1996) Cell , vol.84 , pp. 633-642
    • Smeal, T.1    Claus, J.2    Kennedy, B.3    Cole, F.4    Guarente, L.5


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