RING1 interacts with multiple polycomb-group proteins and displays tumorigenic activity

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 57-68

  Satijn, David P E ^a   Otte, Arie P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; DROSOPHILA; GENE OVEREXPRESSION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; TRANSCRIPTION REGULATION;

EID: 0032927872     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.1.57     Document Type: Article

References (36)

1. Alkema, M. J., M. Bronk, E. Verhoeven, A. P. Otte, L. J. van't Veer, A. Berns, and M. van Lohuizen. 1997. Identification of Bmi1-Interacting proteins as constituents of a multimeric mammalian Polycomb complex. Genes Dev. 11: 226-240.
2. Alkema, M. J., H. Jacobs, M. Van Lohuizen, and A. Berns. 1997. Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmiI transgenic mice require the Bmi1 RING finger. Oncogene 15:899-910.
3. Bradley, M. O., A. R. Kraynak, R. D. Storer, and J. B. Gibbs. 1986. Experimental metastasis in nude mice of NIH 3T3 cells containing various ras genes. Proc. Natl. Acad. Sci. USA 83:5277-5281.
4. Buchenau, P., J. Hodgson, H. Strutt, and D. J. Arndt-Jovin. 1998. The distribution of polycomh-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. J. Cell Biol. 141:469-481.
5. Cohen, K. J., J. S. Hanna, J. E. Prescolt, and C. V. Dang. 1996. Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol. Cell. Biol. 16:5527-5535.
6. Franke, A., M. DeCamillis, D. Zink, N. Cheng, H. W. Brock, and R. Paro. 1992. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11:2941-2950.
7. Freemont, P. S., I. M. Hanson, and J. Townsdale. 1991. A novel cysteine-rich sequence element. Cell 64:483-184.
8. Gould, A. 1997. Functions of mammalian Polycomb group and trithorax group related genes. Curr. Opin. Genet. Dev. 7:488-494.
9. Gunster, M. J., D. P. E. Salijn, K. M. Hamer, J. L. den Blaauwen, D. de Bruijn, M. J. Alkema, M. van Luhuizen, R. van Driel, and A. P. Otte. 1997 Identification and characterization of interactions between the vertebrate Polycomh-group protein BMI1 and human homologs of Polyhomeotic. Mol. Cell. Biol. 17:2326-2335.
10. Hashimoto, N., H. W. Brock, M. Nomura, M. Kyba, J. Hodgson, Y. Fujita, Y. Takihara, K. Shimada, and T. Higashinakagawa. 1998. RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes. Biochem. Biophys. Res. Commun. 245:356-365.
11. Haupt, Y., W. S. Alexander, G. Barri, S. P. Klinken, and J. M. Adams. 1991. Novel zinc linger gene implicated as myc collaborator by retrovirally accelerated lymphogenesis in E(mu)-myc transgenic mice. Cell 65:753-763.
12. Hemenway, C. S., B. W. Halligan, and L. S. Levy. 1998. The Bmi-1 oncoprolein interacts with dinG and Mph2: the role of RING1 finger domains. Oncogene 16:2541-2547.
13. Kanno, M., M. Hasegawa, A. Ishida, K. Isono, and M. Taniguchi. 1995. mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J. 14:5672-5678.
14. Kingston, R. E., C. A. Bunker, and A. N. Imbalzano. 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10:905-920.
15. Lessard, J., S. Baban, and G. Sauvageau. 1998. Stage-specific expression of polycomb group genes in human bone marrow cells. Blood 91:1216-1224.
16. Lewis, E. B. 1978. A gene complex controlling segmentation in Drosophila. Nature 276:565-570.
17. Pelegri, F., and R. Lehmann. 1994. A role of Polycomb group genes in the regulation of Gap gene expression in Drosophila. Genetics 136:1341-1353.
18. Rastelli, L., C. S. Chan, and V. Pirotta. 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J. 12:1513-1522.
19. Reijnen, M. J., K. M. Hamer, J. L. den Blaauwen, C. Lambrechts, I. Schoneveld, R. van Driel, and A. P. Otte. 1995. Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mech. Dev. 53:35-46.
20. Samuels, M. L., M. J. Weber, J. M. Bishop, and M. McMahon. 1993. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human Raf-1 protein kinase. Mol. Cell. Biol. 13:6241-6252.
21. Satijn, D. P. E., M. J. Gunster, J. van de Vlag, K. M. Hamer, W. Schul, M. J. Alkema, A. J. Saurin, F. S. Freemont, R. van Driel, and A. P. Otte. 1997. RING1 is associated with the Polycomb-group protein complex and acts as a transcriptional repressor. Mol. Cell. Biol. 17:4105-4113.
22. Satijn, D. P. E., D. J. Olson, J. Van der Vlag, K. M. Hamer, C. Lambrechts, H. Masselink, M. J. Gunster, R. G. A. B. Sewalt, R. Van Driel, and A. P. Otte. 1997. Interference with the expression of a novel human Polycomb protein. HPC2, results in cellular transformation and apoptosis. Mol. Cell. Biol. 17: 6076-6086.
23. Schoorlemmer, J., C. Marcos, F. Were, R. Martinez, E. Garcia, D. P. E. Satijn, A. P. Otte, and M. Vidal. 1997. Ring1 A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boudaries in the mouse hindbrain. EMBO J. 16:5930-5942.
24. Schumacher, A., and T. Magnuson. 1997. Murine Polycomb-and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13:167-170.
25. Schutte, J., J. Viallet, M. Nau, S. Segal, J. Fedorko, and J. Minna. 1989. Jun-B inhibits and c-fos stimulates the transforming and transactivating activities of c-jun. Cell 59:987-997.
26. Sewalt, R. G. A. B., J. van der Vlag, M. J. Gunster, K. M. Hamer, J. L. den Blaauwen, D. P. E. Satijn, T. Hendrix, R. van Driel, and A. P. Otte. 1998. Characterization of interactions between the mammalian Polycomb-group proteins Env1 EZH2 and EED suggests the existence of different mammalian Polycomb-group protein complexes. Mol. Cell. Biol. 18:3586-3595.
27. Simon, J. 1995. Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7:376-385.
28. Small, M. B., N. Hay, M. Schwab, and J. M. Bishop. 1987. Neoplastic transformation by the human gene N-myc. Mol. Cell. Biol. 7:1638-1645.
29. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
30. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzanu, E. K. Fujimoto, N. M. Goeke, B. J. Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:76-85.
31. Stone, J., T. de Lange, G. Ramsay, E. Jokobovits, J. M. Bishop, H. E. Varmus, and W. M. Lee. 1987. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol. Cell. Biol. 7:1697-1709.
32. Strutt, H., and R. Paro. 1997. The Polycomb group protein complex of Drosophila has different compositions at different target genes. Mol. Cell. Biol. 17:6773-6783.
33. Van Lohuizen, M., S. Verbeek, B. Scheijen, E. Wientjes, H. van der Gulden, and A. Berns. 1991. Identification of cooperating oncogenes in E(mu)-myc transgenic mice by provirus tagging. Cell 65:737-752.
34. Van Lohuizen, M., M. Thijms, J. W. Voncken, A. Schumacher, T. Magnuson, and E. Witntjes. 1998. Interaction of mouse Polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol. Cell. Biol. 18:3572-3579.
35. Wallace, J. S., A. J. Hayle, A. J. Syms, M. Cairney, B. Tutty, A. Gazzard, M. F. Evans, K. A. Fleming, and D. Tarin. 1989. The ras oncogene and tumour metastasis: observations on murine cells transfected with activated human c-Ha-ras. Differentiation 41:208-215.
36. Zink, B., and R. Paro. 1989. In vivo binding pattern of a transregulator of homeotic genes in Drosophila melanogaster. Nature 337:468-471.