Signal-specific co-activator domain requirements for Pit-1 activation

Nature

Volumn 395, Issue 6699, 1998, Pages 301-306

  Xu, Lan ^a   Lavinsky, Robert M ^a   Dasen, Jeremy S ^a   Flynn, Sarah E ^a   McInerney, Eileen M ^a   Mullen, Tina Marie ^a   Heinzel, Thorsten ^a   Szeto, Daniel ^a   Korzus, Edward ^a   Kurokawa, Riki ^a   Aggarwal, Aneel K ^b   Rose, David W ^a   Glass, Christopher K ^a   Rosenfeld, Michael G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR PIT 1;

ARTICLE; COMPLEX FORMATION; GENE ACTIVATION; GENE EXPRESSION; GENE REPRESSION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACETYLTRANSFERASES; BINDING, COMPETITIVE; CELL CYCLE PROTEINS; CELL LINE; CREB-BINDING PROTEIN; CYCLIC AMP; DNA-BINDING PROTEINS; GROWTH SUBSTANCES; HELA CELLS; HISTONE ACETYLTRANSFERASES; HOMEODOMAIN PROTEINS; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR PIT-1; TRANSCRIPTION FACTORS;

EID: 0032541637     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/26270     Document Type: Article

References (28)

1. Gray, S. & Levine, M. Transcriptional repression in development. Curr. Opin. Cell Biol. 8, 358 364 (1996).
2. Hermesz, E., Mackem, S. & Mahon, K. A. Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechorda plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development 122, 41-52 (1996).
3. Ingraham, H. A. et al. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 55, 519-529 (1988).
4. Horlein, A. J. et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397-404 (1995).
5. Chen, J. D. & Evans, R. M. A transcriptional co-repressor that interactions with nuclear hormone receptors. Nature 377, 454-457 (1995).
6. Heinzel, T. et al. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387, 43-48 (1997).
7. Alland, L. et al. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387, 49-55 (1997).
8. Laherty, C. D. et al. Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression. Cell 89, 349-356 (1997).
9. Chrivia, J. C. et al. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859 (1993).
10. Yang, X.-Y., Ogryzko, V. V., Nishikawa, J., Howard, B. H. & Nakatani, Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319-324 (1996).
11. Ogryzko, V. V., Schlitz, R. L., Russanova, V., Howard, B. H. & Nakatani, Y. The transcriptional coactivator p300 and CBP are histone acetyltransferases. Cell 87, 953-960 (1996).
12. Bannister, A. J. & Kouzarides, T. The CBP coactivator is a histone acetyltransferase. Nature 384, 641-643 (1996).
13. Yang, W.-M., Inouye, C., Zeng, Y., Bearss, D. & Seto, E. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator HDAC2/mRPD3. Proc. Natl Acad. Sci. USA 93, 12845-12850 (1996).
14. Kurokawa, R. et al. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377, 451-454 (1995).
15. Kamei, Y. et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414 (1996).
16. Lavinsky, R. M. et al. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl Acad. Sci. USA 95, 2920-2925 (1998).
17. Lundblad, J. R., Kwok, R. P., Laurance, M. E., Harter, M. L. & Goodman, R. H. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374, 85-88 (1995).
18. Glass, C. K., Lipkin, S. M., Devary, O. V. & Rosenfeld, M. G. Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell 59, 697-708 (1989).
19. Jacobson, E. M., Li, P., Leon-del-Rio, A., Rosenfeld, M. G. & Aggarwal, A. K. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev. 11, 198-212 (1997).
20. Elsholtz, H. P., Lew, A. M., Albert, P. R. & Sundmark, V. C. Inhibitory control of prolactin and Pit-1 gene promoters by dopanline. J. Biol. Chem. 266, 22919-22925 (1991).
21. Murdoch, G. H., Waterman, M., Evans, R. M. & Rosenfeld, M. G. Molecular mechanism of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription. J. Biol. Chem. 260, 11852-11858 (1985).
22. Howard, P. W. & Maurer, R. A. A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways. J. Biol. Chem. 270, 20930-20936 (1995).
23. Okimura, Y., Howard, P. W. & Maurer, R. A. Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1. Mol. Endocrinol. 8, 1559-1565 (1994).
24. Kapiloff, M. S., Farkash, Y., Wegner, M. & Rosenfeld, M. G. Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements. Science 253, 786-789 (1991).
25. Õnate, S. A., Tsai, S. Y., Tsai, M.-J. & O'Malley, B. W. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-1357 (1995).
26. Torchia, J. et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-684 (1997).
27. Korzus, E. et al. Transcriptional factor-specific requirements for coactivators and their acetyltransferase functions. Science 279, 703-707 (1998).
28. Rose D. W., McCabe, G., Feramisco, J. R. & Adler, M. Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis. J. Cell. Biol. 119, 1405-1411 (1992).