The CtBP family: Enigmatic and enzymatic transcriptional co-repressors

BioEssays

Volumn 23, Issue 8, 2001, Pages 683-690

  Turner, Jeremy ^a   Crossley, Merlin ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CHROMATIN STRUCTURE; DIMERIZATION; DNA BINDING PROTEIN; DNA SEQUENCE; GENETIC REGULATION; GENETIC TRANSCRIPTION; GOLGI COMPLEX; TRANSCRIPTION FACTOR;

ALCOHOL OXIDOREDUCTASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA-BINDING PROTEINS; HISTONE DEACETYLASES; PHOSPHOPROTEINS; REPRESSOR PROTEINS;

MAMMALIA;

EID: 0034865435     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.1097     Document Type: Review

References (57)

1. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
2. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
3. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
4. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid
5. Interaction of short-range repressors with Drosophila CtBP in the embryo
6. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation
7. The CtBP-binding domain in the adenovirus E1A protein controls CR1-dependent transactivation
8. Drosophila CtBP: A Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
9. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
10. C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
11. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
12. ZEB represses transcription through interaction with the corepressor CtBP
13. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation
14. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1
15. Human Kruppel-like factor 8: A CACCC-box binding protein that associates with CtBP and represses transcription
16. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
17. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
18. Association of the CtBP and MITR corepressors contributes to transcriptional repression of the MEF2 transcription factor
19. A novel GATA factor transcriptionally represses yolk protein precursor genes in the mosquito Aedes aegypti via interaction with the CtBP corepressor
20. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3
21. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
22. Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins
23. Structural determinants in adenovirus 12 E1A involved in the interaction with C-terminal binding protein 1
24. Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP
25. FOG acts as a repressor of red blood cell development in Xenopus
26. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
27. Key residues characteristic of GATA N-fingers are recognized by FOG
28. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
29. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
30. Characterization of a carboxy-terminal BRCA1 interacting protein
31. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
32. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
33. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
34. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex
35. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye
36. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression
37. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
38. Ikaros DNA-binding proteins direct formation of chromatin remodelling complexes in lymphocytes
39. Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex
40. + and ADP-ribosylation in the maintenance of the Golgi structure
41. Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure
42. The Sir2 protein family: A novel deacetylase for gene silencing and more
43. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acety/-ADP-ribose
44. + in the deacetylase activity of the SIR2-like proteins
45. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
46. Sir2 links chromatin silencing, metabolism, and aging
47. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
48. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
49. dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo
50. dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein
51. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
52. Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
53. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression
54. XCtBP s a XTcf3 co-repressor with roles throughout Xenopus development
55. Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila
56. Functional analysis of the human TAFII250 N-terminal kinase domain
57. Moonlighting proteins