Gene silencing: Two faces of SIR2

Current Biology

Volumn 10, Issue 19, 2000, Pages

  Gottschling, Daniel E ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA;

EID: 0034609758     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00714-4     Document Type: Review

References (24)

1. Types of visible variations induced by X-rays in Drosophila
2. Heterochromatin function in complex genomes
3. X-chromosome inactivation
4. Polycombing the genome: PcG, trxG, and chromatin silencing
5. Nuclear neighbours: The spatial and functional organization of genes and nuclear domains
6. Silencing and heritable domains of gene expression
7. The histone tails of the nucleosome
8. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern
9. Mechanisms of silencing in Saccharomyces cerevisiae
10. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
11. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
12. An unusual form of transcriptional silencing in yeast ribosomal DNA
13. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity
14. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
15. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2
16. CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2
17. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
18. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
19. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
20. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
21. +-dependent protein deacetylase activity in the Sir2 protein family
22. Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function