HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling

Molecular and Cellular Biology

Volumn 21, Issue 17, 2001, Pages 6080-6089

  Iso, T ^a   Sartorelli, V ^a   Poizat, C ^a   Iezzi, S ^a   Wu, H Y ^a   Chung, G ^a   Kedes, L ^a   Hamamori, Y ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; HISTONE DEACETYLASE; NOTCH RECEPTOR; PROTEIN HERP; PROTEIN HES E SPL; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DNA BINDING; GENE REPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; DNA; GENE EXPRESSION REGULATION; HELA CELLS; HELIX-LOOP-HELIX MOTIFS; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEINS; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SOLUTIONS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0034903573     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.17.6080-6089.2001     Document Type: Article

References (50)

1. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
2. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
3. Notch signalling controls pancreatic cell differentiation
4. Notch signaling: Cell fate control and signal integration in development
5. Histone deacetylases: Transcriptional repression with SINers and NuRDs
6. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
7. Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection
8. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development
9. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
10. Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system
11. Histone deacetylase associated with mSin3A mediates repression by the acute promyeloyti leukemia-associated PLZF protein
12. Specificity for the Hairy/Enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression
13. Conservation of the Notch signalling pathway in mammalian neurogenesis
14. Notch receptors, partners and regulators: From conserved domains to powerful functions
15. The function of hairy-related bHLH repressor proteins in cell fate decisions
16. Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
17. The WRPW motif of the Hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
18. Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis
19. LIN-12/Notch signaling: Lessons from worms and flies
20. The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein
21. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
22. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
23. HERP, a new primary target of Notch regulated by ligand binding
24. Target specificities of Drosophila Enhancer of split basic helix-loop-helix proteins
25. Combinatorial roles of the nuclear receptor corepressor in transcription and development
26. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
27. Sin meets NuRD and other tails of repression
28. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split
29. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
30. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors
31. Hey genes: A novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis
32. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers
33. Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation
34. Comparative analysis of the human and mouse Heyl promoter: Hey genes are new Notch target genes
35. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
36. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
37. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling
38. HRT1, HRT2, and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
39. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
40. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
41. Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation
42. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
43. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
44. Molecular mechanisms of myogenic coactivation by p300: Direct interaction with the activation domain of MyoD and with the MADS box of MEF2C
45. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
46. Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements
47. her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling
48. Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein
49. Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains
50. Gridlock, an HLH gene required for assembly of the aorta in zebrafish