메뉴 건너뛰기




Volumn 11, Issue 12, 2002, Pages 1715-1736

Therapies directed at vascular endothelial growth factor

Author keywords

Angiogenesis; Angiozyme; Avastatin; Bevazizumab; IMC 1C11; PTK787; SU11248; Vatalanib; VEGF; VEGF receptors; ZD6474; ZK222584

Indexed keywords

3 (4 BROMO 2,6 DIFLUOROBENZYLOXY) 5 [3 [4 (1 PYRROLIDINYL)BUTYL]UREIDO] 4 ISOTHIAZOLECARBOXAMIDE; 5,6,7,13 TETRAHYDRO 12 (3 HYDROXYPROPYL) 9 ISOPROPOXYMETHYLINDENO[2,1 A]PYRROLO[3,4 C]CARBAZOL 5(12H) ONE DIMETHYLGLYCINE ESTER; ANGIOGENESIS INHIBITOR; ANGIOYZME; ANGIOZYME; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CYTOTOXIC AGENT; DOXORUBICIN; FLUOROURACIL; FOLINIC ACID; NEUROPILIN 1; NEUROPILIN 2; NEUTRALIZING ANTIBODY; PACLITAXEL; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RIBOZYME; RPI 4610; SEMAXANIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VATALANIB; VINBLASTINE; ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; SIGNAL PEPTIDE; VASCULOTROPIN A;

EID: 0036915886     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.11.12.1715     Document Type: Review
Times cited : (97)

References (199)
  • 1
    • 0008885761 scopus 로고
    • Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells
    • GOSPODAROWICZ D, ABRAHAM JA, SCHILLING J: Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc. Natl. Acad. Sci. USA (1989) 86:7311-7315.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7311-7315
    • Gospodarowicz, D.1    Abraham, J.A.2    Schilling, J.3
  • 2
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • FERRARA N, HENZEL WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. (1989) 161:851-858.
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 3
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • SENGER DR, GALLI SJ, DVORAK AM et al.: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (1983) 219:983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 4
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • HOUCK KA, FERRARA N, WINER J et al.: The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. (1991) 5:1806-1814.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3
  • 5
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform specific receptor for vascular endothelial growth factor
    • SOKER S, TAKASHIMA S, MIAO HQ, NEUFELD G, KLAGSBRUN M: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform specific receptor for vascular endothelial growth factor. Cell (1998) 92:735-745.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 6
    • 0035902538 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-β-deficient mice display an atrial conduction defect
    • AASE K, VON EULER G, LI X et al.: Vascular endothelial growth factor-β-deficient mice display an atrial conduction defect. Circulation (2001) 104:358-364.
    • (2001) Circulation , vol.104 , pp. 358-364
    • Aase, K.1    Von Euler, G.2    Li, X.3
  • 7
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • CARMELIET P, MOONS L, LUTTUN A et al.: Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. (2001) 7(5):575-583.
    • (2001) Nat. Med. , vol.7 , Issue.5 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3
  • 8
    • 0035719850 scopus 로고    scopus 로고
    • Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2
    • KIRKIN V, MAZITSCHEK R, KRISHNAN J et al.: Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Eur. J. Biochem. (2001) 268:5530-5540.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 5530-5540
    • Kirkin, V.1    Mazitschek, R.2    Krishnan, J.3
  • 10
    • 0034842967 scopus 로고    scopus 로고
    • Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
    • SKOBE M, HAMBERG LM, HAWIGHORST T et al.: Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am. J. Pathol. (2001) 159:893-903.
    • (2001) Am. J. Pathol. , vol.159 , pp. 893-903
    • Skobe, M.1    Hamberg, L.M.2    Hawighorst, T.3
  • 11
    • 17744390184 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
    • MANDRIOTA SJ, JUSSILA L, JELTSCH M et al.: Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. (2001) 20:672-682.
    • (2001) EMBO J. , vol.20 , pp. 672-682
    • Mandriota, S.J.1    Jussila, L.2    Jeltsch, M.3
  • 12
    • 0030932842 scopus 로고    scopus 로고
    • Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1
    • BARLEON B, TOTZKE F, HERZOG C et al.: Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1. J. Biol. Chem. (1997) 272:10382-10388.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10382-10388
    • Barleon, B.1    Totzke, F.2    Herzog, C.3
  • 13
    • 0032080310 scopus 로고    scopus 로고
    • Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor
    • FUH G, LI B, CROWLEY C, CUNNINGHAM B, WELLS JA: Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J. Biol. Chem. (1998) 273:11197-11204.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11197-11204
    • Fuh, G.1    Li, B.2    Crowley, C.3    Cunningham, B.4    Wells, J.A.5
  • 14
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • SHALABY F, ROSSANT J, YAMAGUCHI TP et al.: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (1995) 376:62-66.
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3
  • 15
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • FONG GH, ROSSANT J, GERTSENSTEIN M, BREITMAN ML: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (1995) 376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 16
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • HIRATSUKA S, MINOWA O, KUNO J, NODA T, SHIBUYA M: Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA (1998) 95:9349-9354.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 17
    • 0034254273 scopus 로고    scopus 로고
    • A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration
    • GILLE H, KOWALSKI J, YU L et al.: A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration. EMBO J. (2000) 19:4064-4073.
    • (2000) EMBO J. , vol.19 , pp. 4064-4073
    • Gille, H.1    Kowalski, J.2    Yu, L.3
  • 18
    • 0036344495 scopus 로고    scopus 로고
    • Revascularisation of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • LUTTUN A, TJWA M, MOONS L et al.: Revascularisation of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. (2002) 8:831-840.
    • (2002) Nat. Med. , vol.8 , pp. 831-840
    • Luttun, A.1    Tjwa, M.2    Moons, L.3
  • 19
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    • KENDALL RL, THOMAS KA: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA (1993) 90:10705-10709.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10705-10709
    • Kendall, R.L.1    Thomas, K.A.2
  • 20
    • 0034007818 scopus 로고    scopus 로고
    • Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids
    • HORNIG C, BARLEON B, AHMAD S et al.: Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids. Lab. Invest. (2000) 80:443-454.
    • (2000) Lab. Invest. , vol.80 , pp. 443-454
    • Hornig, C.1    Barleon, B.2    Ahmad, S.3
  • 21
    • 0030609013 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells
    • BARLEON B, SIEMEISTER G, MARTINY-BARON G et al.: Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. Cancer Res. (1997) 57:5421-5425.
    • (1997) Cancer Res. , vol.57 , pp. 5421-5425
    • Barleon, B.1    Siemeister, G.2    Martiny-baron, G.3
  • 22
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • ASAHARA T, MUROHARA T, SULLIVAN A et al.: Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 275:964-967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 24
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • CARMELIET P, FERREIRA V, BREIER G et al.: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 380:435-439.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3
  • 25
    • 0037182861 scopus 로고    scopus 로고
    • VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
    • GERBER HP, MALIK AK, SOLAR GP et al.: VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature (2002) 417:954-958.
    • (2002) Nature , vol.417 , pp. 954-958
    • Gerber, H.P.1    Malik, A.K.2    Solar, G.P.3
  • 26
    • 0026723142 scopus 로고
    • The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules
    • GITAY-GOREN H, SOKER S, VLODAVSKY I, NEUFELD G: The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. J. Biol. Chem. (1992) 267:6093-6098.
    • (1992) J. Biol. Chem. , vol.267 , pp. 6093-6098
    • Gitay-goren, H.1    Soker, S.2    Vlodavsky, I.3    Neufeld, G.4
  • 27
    • 0029670002 scopus 로고    scopus 로고
    • Selective binding of VEGF121 to one of the three VEGF receptors of vascular endothelial cells
    • GITAY-GOREN H, COHEN T, TESSLER S et al.: Selective binding of VEGF121 to one of the three VEGF receptors of vascular endothelial cells. J. Biol. Chem. (1996) 271:5519-5523.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5519-5523
    • Gitay-goren, H.1    Cohen, T.2    Tessler, S.3
  • 28
    • 0035816698 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)
    • WHITAKER GB, LIMBERG BJ, ROSENBAUM JS: Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121). J. Biol. Chem. (2001) 276:25520-25531.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25520-25531
    • Whitaker, G.B.1    Limberg, B.J.2    Rosenbaum, J.S.3
  • 29
    • 0032575576 scopus 로고    scopus 로고
    • Neuropilin-1 is a placenta growth factor-2 receptor
    • MIGDAL M, HUPPERTZ B, TESSLER S et al.: Neuropilin-1 is a placenta growth factor-2 receptor. J. Biol. Chem. (1998) 273:22272-22278.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22272-22278
    • Migdal, M.1    Huppertz, B.2    Tessler, S.3
  • 30
    • 0033597813 scopus 로고    scopus 로고
    • Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1
    • MAKINEN T, OLOFSSON B, KARPANEN T et al.: Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. J. Biol. Chem. (1999) 274:21217-21222.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21217-21222
    • Makinen, T.1    Olofsson, B.2    Karpanen, T.3
  • 31
    • 0030829388 scopus 로고    scopus 로고
    • Neuropilin is a semaphorin III receptor
    • KOLODKIN AL, LEVENGOOD DV, ROWE EG et al.: Neuropilin is a semaphorin III receptor. Cell (1997) 90:753-762.
    • (1997) Cell , vol.90 , pp. 753-762
    • Kolodkin, A.L.1    Levengood, D.V.2    Rowe, E.G.3
  • 32
    • 0034554844 scopus 로고    scopus 로고
    • VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis
    • HAMADA K, OIKE Y, TAKAKURA N et al.: VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis. Blood (2000) 96:3793-3800.
    • (2000) Blood , vol.96 , pp. 3793-3800
    • Hamada, K.1    Oike, Y.2    Takakura, N.3
  • 33
    • 17744396472 scopus 로고    scopus 로고
    • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
    • VEIKKOLA T, JUSSILA L, MAKINEN T et al.: Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. (2001) 20:1223-1231.
    • (2001) EMBO J. , vol.20 , pp. 1223-1231
    • Veikkola, T.1    Jussila, L.2    Makinen, T.3
  • 34
    • 0035122695 scopus 로고    scopus 로고
    • Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
    • MAKINEN T, JUSSILA L, VEIKKOLA T et al.: Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat. Med. (2001) 7:199-205.
    • (2001) Nat. Med. , vol.7 , pp. 199-205
    • Makinen, T.1    Jussila, L.2    Veikkola, T.3
  • 36
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • CARMELIET P, JAIN RK: Angiogenesis in cancer and other diseases. Nature (2000) 407:249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 37
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and the near future
    • KERBEL RS: Tumor angiogenesis: past, present and the near future. Carcinogenesis (2000) 21:505-515.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 38
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • HANAHAN D, WEINBERG RA: The hallmarks of cancer. Cell (2000) 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 40
    • 0035187771 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Its prognostic, predictive, and therapeutic implications
    • TOI M, MATSUMOTO T, BANDO H: Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications. Lancet Oncol. (2001) 2(11):667-673.
    • (2001) Lancet Oncol. , vol.2 , Issue.11 , pp. 667-673
    • Toi, M.1    Matsumoto, T.2    Bando, H.3
  • 41
    • 0027482251 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
    • BROWN LF, BERSE B, JACKMAN RW et al.: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res. (1993) 53:4727-4735.
    • (1993) Cancer Res. , vol.53 , pp. 4727-4735
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3
  • 42
    • 0030051874 scopus 로고    scopus 로고
    • Prognostic significance of the microvascular count in colorectal cancer
    • LINDMARK G, GERDIN B, SUNDBERG C et al.: Prognostic significance of the microvascular count in colorectal cancer. J. Clin. Oncol. (1996) 14:461-466.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 461-466
    • Lindmark, G.1    Gerdin, B.2    Sundberg, C.3
  • 43
    • 0033991167 scopus 로고    scopus 로고
    • Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer
    • ITAKURA J, ISHIWATA T, SHEN B et al.: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int. J. Cancer (2000) 85:27-34.
    • (2000) Int. J. Cancer , vol.85 , pp. 27-34
    • Itakura, J.1    Ishiwata, T.2    Shen, B.3
  • 44
    • 0028861231 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
    • BROWN LF, BERSE B, JACKMAN RW et al.: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Human Path. (1995) 26:86-91.
    • (1995) Human Path. , vol.26 , pp. 86-91
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3
  • 45
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis. Correlation in invasive breast carcinoma
    • WEIDNER N, SEMPLE P, WELCH W, FOLKMAN J: Tumor angiogenesis and metastasis. Correlation in invasive breast carcinoma. N. Engl. J. Med. (1991) 324:1-6.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1-6
    • Weidner, N.1    Semple, P.2    Welch, W.3    Folkman, J.4
  • 46
    • 0029892750 scopus 로고    scopus 로고
    • Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinoma
    • TANIGAWA N, AMAYA H, MATSUMURA M et al.: Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinoma. Cancer Res. (1996) 56:2671-2676.
    • (1996) Cancer Res. , vol.56 , pp. 2671-2676
    • Tanigawa, N.1    Amaya, H.2    Matsumura, M.3
  • 47
    • 0029155712 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia
    • GUIDI A, ABU-JAWDEH G, BERSE B et al.: Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J. Natl. Cancer Inst. (1995) 87:1237-1245.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1237-1245
    • Guidi, A.1    Abu-jawdeh, G.2    Berse, B.3
  • 48
    • 0019381333 scopus 로고
    • The significance of atypical vessels and neovascularization in cervical neoplasias
    • SILLMAN F, BOYCE J, FRUCHTER R: The significance of atypical vessels and neovascularization in cervical neoplasias. Am. J. Obstet. Gynecol. (1981) 139:154-157.
    • (1981) Am. J. Obstet. Gynecol. , vol.139 , pp. 154-157
    • Sillman, F.1    Boyce, J.2    Fruchter, R.3
  • 49
    • 0027768808 scopus 로고
    • Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas
    • BROWN LF, BERSE B, JACKMAN RW et al.: Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol. (1993) 143:1255-1262.
    • (1993) Am. J. Pathol. , vol.143 , pp. 1255-1262
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3
  • 50
    • 0028884557 scopus 로고
    • Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis
    • BOCHNER BH, COTE RJ, WEIDNER N et al.: Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J. Natl. Cancer Inst. (1995) 87:1603-1612.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1603-1612
    • Bochner, B.H.1    Cote, R.J.2    Weidner, N.3
  • 51
    • 0027476565 scopus 로고
    • Comparison of microscopic vascularity in benign and malignant prostatic tissue
    • BIGLER SA, DEERING RE, BRAWER MK: Comparison of microscopic vascularity in benign and malignant prostatic tissue. Human Pathol. (1993) 24:220-226.
    • (1993) Human Pathol. , vol.24 , pp. 220-226
    • Bigler, S.A.1    Deering, R.E.2    Brawer, M.K.3
  • 52
    • 0028153737 scopus 로고
    • Vascular permeability factor gene expression in normal and neoplastic human ovaries
    • OLSON TA, MOHANRAJ D, CARSON LF, RAMAKRISHNAN S: Vascular permeability factor gene expression in normal and neoplastic human ovaries. Cancer Res. (1994) 54:276-280.
    • (1994) Cancer Res. , vol.54 , pp. 276-280
    • Olson, T.A.1    Mohanraj, D.2    Carson, L.F.3    Ramakrishnan, S.4
  • 53
    • 8944227508 scopus 로고    scopus 로고
    • Prognostic and predictive value of tumour angiogenesis in ovarian carcinomas
    • GASPARINI G, BONOLDI E, VIALE G et al.: Prognostic and predictive value of tumour angiogenesis in ovarian carcinomas. Int. J. Cancer (1996) 69:205-211.
    • (1996) Int. J. Cancer , vol.69 , pp. 205-211
    • Gasparini, G.1    Bonoldi, E.2    Viale, G.3
  • 54
    • 0029942159 scopus 로고    scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma
    • GUIDI AJ, ABU-JAWDEH G, TOGNAZZI K, DVORAK HF, BROWN LF: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma. Cancer (1996) 78:454-460.
    • (1996) Cancer , vol.78 , pp. 454-460
    • Guidi, A.J.1    Abu-jawdeh, G.2    Tognazzi, K.3    Dvorak, H.F.4    Brown, L.F.5
  • 56
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human glioma in vivo
    • PLATE KH, BREIER G, WEICH HA, RISAU W: Vascular endothelial growth factor is a potential tumor angiogenesis factor in human glioma in vivo. Nature (1992) 359:845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 57
    • 0028275909 scopus 로고
    • Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumors
    • LI VW, FOLKERTH RD, WATANABE H et al.: Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumors. Lancet (1994) 344:82-86.
    • (1994) Lancet , vol.344 , pp. 82-86
    • Li, V.W.1    Folkerth, R.D.2    Watanabe, H.3
  • 58
    • 0026775205 scopus 로고
    • Angiogenesis and tumor progression of melanoma: Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma
    • BARNHILL RL, FANDREY K, LEVY MA, MIHM MC, HYMAN B: Angiogenesis and tumor progression of melanoma: quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma. Lab. Invest. (1992) 67:331-337.
    • (1992) Lab. Invest. , vol.67 , pp. 331-337
    • Barnhill, R.L.1    Fandrey, K.2    Levy, M.A.3    Mihm, M.C.4    Hyman, B.5
  • 59
    • 0029993747 scopus 로고
    • Strong expression of KDR, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma
    • BROWN LF, TOGNAZZI K, DVORAK H, HARRIST T: Strong expression of KDR, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Am. J. Pathol. (1995) 148:1065-1074.
    • (1995) Am. J. Pathol. , vol.148 , pp. 1065-1074
    • Brown, L.F.1    Tognazzi, K.2    Dvorak, H.3    Harrist, T.4
  • 60
    • 0027437509 scopus 로고
    • Intratumoral microvessel density and p53 protein: Correlation with metastasis in head-and neck squamous-cell carcinomas
    • GASPARINI G, WEIDNER N, MALUTA S et al.: Intratumoral microvessel density and p53 protein: correlation with metastasis in head-and neck squamous-cell carcinomas. Int. J. Cancer (1993) 57:739-744.
    • (1993) Int. J. Cancer , vol.57 , pp. 739-744
    • Gasparini, G.1    Weidner, N.2    Maluta, S.3
  • 61
    • 0027534287 scopus 로고
    • Expression of vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms
    • BERKMAN RA, MERRILL MJ, REINHOLD WC et al.: Expression of vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest. (1993) 91:153-159.
    • (1993) J. Clin. Invest. , vol.91 , pp. 153-159
    • Berkman, R.A.1    Merrill, M.J.2    Reinhold, W.C.3
  • 62
    • 0028929991 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
    • WIZIGMANN-VOOS S, BREIER G, RISAU W, PLATE KH: Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. (1995) 55:1358-1364.
    • (1995) Cancer Res. , vol.55 , pp. 1358-1364
    • Wizigmann-voos, S.1    Breier, G.2    Risau, W.3    Plate, K.H.4
  • 63
    • 0033083962 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies
    • BELLAMY WT, RICHTER L, FRUTIGER Y, GROGAN TM: Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res. (1999) 59:728-733.
    • (1999) Cancer Res. , vol.59 , pp. 728-733
    • Bellamy, W.T.1    Richter, L.2    Frutiger, Y.3    Grogan, T.M.4
  • 64
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • LYDEN D, HATTORI K, DIAS S et al.: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. (2001) 7:1194-1201.
    • (2001) Nat. Med. , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3
  • 65
    • 0032838197 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptors in human prostate cancer
    • FERRER FA, MILLER LJ, LINDQUIST R et al.: Expression of vascular endothelial growth factor receptors in human prostate cancer. Urology (1999) 54:567-572.
    • (1999) Urology , vol.54 , pp. 567-572
    • Ferrer, F.A.1    Miller, L.J.2    Lindquist, R.3
  • 66
    • 0034891532 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype
    • SOKER S, KAEFER M, JOHNSON M et al.: Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype. Am. J. Pathol. (2001) 159:651-659.
    • (2001) Am. J. Pathol. , vol.159 , pp. 651-659
    • Soker, S.1    Kaefer, M.2    Johnson, M.3
  • 67
    • 0034950008 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and VEGF receptor Flk-1 in benign, premalignant, and malignant prostate tissue
    • KOLLERMANN J, HELPAP B: Expression of vascular endothelial growth factor (VEGF) and VEGF receptor Flk-1 in benign, premalignant, and malignant prostate tissue. Am. J. Clin. Pathol. (2001) 116:115-121.
    • (2001) Am. J. Clin. Pathol. , vol.116 , pp. 115-121
    • Kollermann, J.1    Helpap, B.2
  • 68
    • 0028904030 scopus 로고
    • Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma
    • BOOCOCK CA, CHARNOCK-JONES DS, SHARKEY AM et al.: Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J. Natl. Cancer Inst. (1995) 87:506-516.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 506-516
    • Boocock, C.A.1    Charnock-Jones, D.S.2    Sharkey, A.M.3
  • 69
    • 0033991167 scopus 로고    scopus 로고
    • Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer
    • ITAKURA J, ISHIWATA T, SHEN B, KORNMANN M, KORC M: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int. J. Cancer (2000) 85:27-34.
    • (2000) Int. J. Cancer , vol.85 , pp. 27-34
    • Itakura, J.1    Ishiwata, T.2    Shen, B.3    Kornmann, M.4    Korc, M.5
  • 70
    • 0034925637 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells
    • PRICE DJ, MIRALEM T, JIANG S, STEINBERG R, AVRAHAM H: Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ. (2001) 12:129-135.
    • (2001) Cell Growth Differ. , vol.12 , pp. 129-135
    • Price, D.J.1    Miralem, T.2    Jiang, S.3    Steinberg, R.4    Avraham, H.5
  • 71
    • 0035422178 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    • BACHELDER RE, CRAGO A, CHUNG J et al.: Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. (2001) 61:5736-5740.
    • (2001) Cancer Res. , vol.61 , pp. 5736-5740
    • Bachelder, R.E.1    Crago, A.2    Chung, J.3
  • 72
    • 0342948906 scopus 로고    scopus 로고
    • Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma
    • KONIG J, TOLNAY E, WIETHEGE T, MULLER K: Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma. Respiration (2000) 67:36-40.
    • (2000) Respiration , vol.67 , pp. 36-40
    • Konig, J.1    Tolnay, E.2    Wiethege, T.3    Muller, K.4
  • 73
    • 0035068834 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma
    • STRIZZI L, CATALANO A, VIANALE G et al.: Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma. J. Pathol. (2001) 193:468-475.
    • (2001) J. Pathol. , vol.193 , pp. 468-475
    • Strizzi, L.1    Catalano, A.2    Vianale, G.3
  • 74
    • 0034518226 scopus 로고    scopus 로고
    • Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor
    • LACAL PM, FAILLA CM, PAGANI E et al.: Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor. J. Invest. Dermatol. (2000) 115:1000-1007.
    • (2000) J. Invest. Dermatol. , vol.115 , pp. 1000-1007
    • Lacal, P.M.1    Failla, C.M.2    Pagani, E.3
  • 75
    • 0032818583 scopus 로고    scopus 로고
    • Expression and localization of placenta growth factor and PIGF receptors in human meningiomas
    • DONNINI S, MACHEIN MR, PLATE KH, WEICH HA: Expression and localization of placenta growth factor and PIGF receptors in human meningiomas. J. Pathol. (1999) 189:66-71.
    • (1999) J. Pathol. , vol.189 , pp. 66-71
    • Donnini, S.1    Machein, M.R.2    Plate, K.H.3    Weich, H.A.4
  • 76
    • 18844471324 scopus 로고    scopus 로고
    • Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors
    • SALVEN P, LYMBOUSSAKI A, HEIKKILA P, JAASKELA-SAARI H et al.: Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors. Am. J. Pathol. (1998) 153:103-108.
    • (1998) Am. J. Pathol. , vol.153 , pp. 103-108
    • Salven, P.1    Lymboussaki, A.2    Heikkila, P.3    Jaaskela-saari, H.4
  • 77
    • 0030933923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia
    • FIEDLER W, GRAEVEN U, ERGUN S et al.: Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood (1997) 89:1870-1875.
    • (1997) Blood , vol.89 , pp. 1870-1875
    • Fiedler, W.1    Graeven, U.2    Ergun, S.3
  • 78
    • 0033861874 scopus 로고    scopus 로고
    • Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration
    • DIAS S, HATTORI K, ZHU Z et al.: Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J. Clin. Invest. (2000) 106:511-521.
    • (2000) J. Clin. Invest. , vol.106 , pp. 511-521
    • Dias, S.1    Hattori, K.2    Zhu, Z.3
  • 79
    • 0033520341 scopus 로고    scopus 로고
    • KDR receptor. A key marker defining hematopoietic stem cells
    • ZIEGLER BL, VALTIERI M, PORADA GA et al.: KDR receptor. A key marker defining hematopoietic stem cells. Science (1999) 285:1553-1558.
    • (1999) Science , vol.285 , pp. 1553-1558
    • Ziegler, B.L.1    Valtieri, M.2    Porada, G.A.3
  • 80
    • 0032427654 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor (VEGF) and placenta-derived growth factor (PIGF) in regulating human haemopoietic cell growth
    • RATAJCZAK MZ, RATAJCZAK J, MACHALINSKI B et al.: Role of vascular endothelial growth factor (VEGF) and placenta-derived growth factor (PIGF) in regulating human haemopoietic cell growth. Br. J. Haematol. (1998) 103:969-979.
    • (1998) Br. J. Haematol. , vol.103 , pp. 969-979
    • Ratajczak, M.Z.1    Ratajczak, J.2    Machalinski, B.3
  • 81
    • 0033888921 scopus 로고    scopus 로고
    • Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis
    • MIOTLA J, MACIEWICZ R, KENDREW J, FELDMANN M, PALEOLOG E: Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. Lab. Invest. (2000) 80:1195-1205.
    • (2000) Lab. Invest. , vol.80 , pp. 1195-1205
    • Miotla, J.1    Maciewicz, R.2    Kendrew, J.3    Feldmann, M.4    Paleolog, E.5
  • 82
    • 0029151047 scopus 로고
    • Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis
    • NAGASHIMA M, YOSHINO S, ISHIWATA T, ASANO G: Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis. J. Rheumatol. (1995) 22:1624-1630.
    • (1995) J. Rheumatol. , vol.22 , pp. 1624-1630
    • Nagashima, M.1    Yoshino, S.2    Ishiwata, T.3    Asano, G.4
  • 83
    • 0028216495 scopus 로고
    • Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue
    • FAVA RA, OLSEN NJ, SPENCER-GREEN G et al.: Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J. Exp. Med (1994) 180:341-346.
    • (1994) J. Exp. Med , vol.180 , pp. 341-346
    • Fava, R.A.1    Olsen, N.J.2    Spencer-green, G.3
  • 84
    • 0032091809 scopus 로고    scopus 로고
    • Angiogenesis: Implications for rheumatoid arthritis
    • KOCH AE: Angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum. (1998) 41:951-962.
    • (1998) Arthritis Rheum. , vol.41 , pp. 951-962
    • Koch, A.E.1
  • 86
    • 0032890051 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Molecular and biological aspects
    • FERRARA N: Vascular endothelial growth factor: molecular and biological aspects. Curr. Top. Microbiol. Immunol. (1999) 237:1-30.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.237 , pp. 1-30
    • Ferrara, N.1
  • 87
    • 0028062822 scopus 로고
    • Vascular endothelial growth factor-its role in retinal vascular proliferation
    • FRANK RN: Vascular endothelial growth factor-its role in retinal vascular proliferation. N. Engl. J. Med. (1994) 331:1519-1520.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1519-1520
    • Frank, R.N.1
  • 88
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • ADAMIS AP, MILLER JW, BERNAL MT et al.: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Opthamol. (1994) 118:445-450.
    • (1994) Am. J. Opthamol. , vol.118 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3
  • 89
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • FOLKMAN J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. (1995) 1:27-31.
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 90
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • AIELLO LP, PIERCE EA, FOLEY ED et al.: Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA (1995) 92:10457-10461.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3
  • 91
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • ALON T, HEMO I, ITIN A, PE'ER J, STONE J, KESHET E: Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. (1995) 1:1024-1028.
    • (1995) Nat. Med. , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 92
    • 0028223727 scopus 로고
    • Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis
    • NICKOLOFF BJ, MITRA RS, VARANI J, DIXIT VM, POLVERINI P: Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Am. J. Pathol. (1994) 144:820-828.
    • (1994) Am. J. Pathol. , vol.144 , pp. 820-828
    • Nickoloff, B.J.1    Mitra, R.S.2    Varani, J.3    Dixit, V.M.4    Polverini, P.5
  • 93
    • 0027980960 scopus 로고
    • Overexpression of vascular permeability factor/vascular endothelial growth factor and it receptors in psoriasis
    • DETMAR M, BROWN LF, CLAFFEY KP et al.: Overexpression of vascular permeability factor/vascular endothelial growth factor and it receptors in psoriasis. J. Exp. Med. (1994) 180:1141-1146.
    • (1994) J. Exp. Med. , vol.180 , pp. 1141-1146
    • Detmar, M.1    Brown, L.F.2    Claffey, K.P.3
  • 94
    • 7144264398 scopus 로고    scopus 로고
    • Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
    • DETMAR M, BROWN LF, SCHON MP et al.: Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J. Investig. Dermatol. (1998) 111:1-6.
    • (1998) J. Investig. Dermatol. , vol.111 , pp. 1-6
    • Detmar, M.1    Brown, L.F.2    Schon, M.P.3
  • 95
    • 0030357278 scopus 로고    scopus 로고
    • Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases
    • SHULMAN K, ROSEN S, TUGNAZZI K, MANSEAU EJ, BROWN LF: Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases. J. Am. Soc. Nephrol (1996) 7:661-666.
    • (1996) J. Am. Soc. Nephrol. , vol.7 , pp. 661-666
    • Shulman, K.1    Rosen, S.2    Tugnazzi, K.3    Manseau, E.J.4    Brown, L.F.5
  • 96
    • 0034130719 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease
    • THOMAS S, VANUYSTEL J, GRUNDEN G et al.: Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease. J. Am. Soc. Nephrol. (2000) 11:1236-1243.
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 1236-1243
    • Thomas, S.1    Vanuystel, J.2    Grunden, G.3
  • 97
    • 0035891725 scopus 로고    scopus 로고
    • Angiogenesis and remodeling of airway vasculature in chronic inflammation
    • McDONALD DM: Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am. J. Resp. Crit. Care Med. (2001) 164:39-45.
    • (2001) Am. J. Resp. Crit. Care Med. , vol.164 , pp. 39-45
    • Mcdonald, D.M.1
  • 98
    • 0035158686 scopus 로고    scopus 로고
    • Human airway smooth muscle cells secrete vascular endothelial growth factor: Up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism
    • KNOX AJ, CORBETT L, STOCKS J, HOLLAND E, ZHU YM, PANG L: Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. FASEB J. (2001) 15:2480-2488.
    • (2001) FASEB J. , vol.15 , pp. 2480-2488
    • Knox, A.J.1    Corbett, L.2    Stocks, J.3    Holland, E.4    Zhu, Y.M.5    Pang, L.6
  • 99
    • 0034092656 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease
    • MEYER KC, CARDONI A, XIANG ZZ: Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease. J. Lab. Clin. Med. (2000) 135:332-338.
    • (2000) J. Lab. Clin. Med. , vol.135 , pp. 332-338
    • Meyer, K.C.1    Cardoni, A.2    Xiang, Z.Z.3
  • 100
    • 0035047885 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances atherosclerotic plague progression
    • CELLETTI F, WAUGH J, AMABILE P et al.: Vascular endothelial growth factor enhances atherosclerotic plague progression. Nat. Med. (2001) 7:425-429.
    • (2001) Nat. Med. , vol.7 , pp. 425-429
    • Celletti, F.1    Waugh, J.2    Amabile, P.3
  • 101
    • 0037080618 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor as a surveillance market for cellular rejection in pediatric cardiac transplantation
    • ABRAMSON LP, PAHL E, HUANG L et al.: Serum vascular endothelial growth factor as a surveillance market for cellular rejection in pediatric cardiac transplantation. Transplantation (2002) 73:153-156.
    • (2002) Transplantation , vol.73 , pp. 153-156
    • Abramson, L.P.1    Pahl, E.2    Huang, L.3
  • 102
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • KIM KJ, LI B, WINER J et al.: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (1993) 362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 103
    • 0033513497 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors
    • SCHLAEPPI J-M, WOOD J: Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors. Cancer Metastasis Rev. (1999) 18:473-481.
    • (1999) Cancer Metastasis Rev. , vol.18 , pp. 473-481
    • Schlaeppi, J.-M.1    Wood, J.2
  • 104
    • 0035336732 scopus 로고    scopus 로고
    • Monoclonal antibody strategies to block angiogenesis
    • HICKLIN DJ, WITTE L, ZHU Z et al.: Monoclonal antibody strategies to block angiogenesis. Drug Discov. Today (2001) 6:517-528.
    • (2001) Drug Discov. Today , vol.6 , pp. 517-528
    • Hicklin, D.J.1    Witte, L.2    Zhu, Z.3
  • 105
    • 0035126049 scopus 로고    scopus 로고
    • VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    • STACKER SA, CAESAR C, BALDWIN ME et al.: VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat. Med. (2001) 7:186-191.
    • (2001) Nat. Med. , vol.7 , pp. 186-191
    • Stacker, S.A.1    Caesar, C.2    Baldwin, M.E.3
  • 106
    • 18544393909 scopus 로고    scopus 로고
    • Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis
    • KUBO H, FUJIWARA T, JUSSILA L et al.: Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. Blood (2000) 96:546-553.
    • (2000) Blood , vol.96 , pp. 546-553
    • Kubo, H.1    Fujiwara, T.2    Jussila, L.3
  • 107
    • 0035034655 scopus 로고    scopus 로고
    • Antibodies against Vascular Endothelial Growth Factor Improve Early Renal Dysfunction in Experimental Diabetes
    • DE VRIESE ANS, TILTON RG, ELGER M, STEPHAN CC, KRIZ W, LAMEIRE NH: Antibodies against Vascular Endothelial Growth Factor Improve Early Renal Dysfunction in Experimental Diabetes. J. Am. Soc. Nephrol. (2001) 12:993-1000.
    • (2001) J. Am. Soc. Nephrol. , vol.12 , pp. 993-1000
    • De Vriese, A.N.S.1    Tilton, R.G.2    Elger, M.3    Stephan, C.C.4    Kriz, W.5    Lameire, N.H.6
  • 109
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • PRESTA LG, CHEN H, O'CONNOR SJ et al.: Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. (1997) 57:4593-4599.
    • (1997) Cancer Res. , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'connor, S.J.3
  • 110
    • 0032530717 scopus 로고    scopus 로고
    • VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface
    • MULLER YA, CHEN Y, CHRISTINGER HW et al.: VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface. Structure (1998) 6:1153-1167.
    • (1998) Structure , vol.6 , pp. 1153-1167
    • Muller, Y.A.1    Chen, Y.2    Christinger, H.W.3
  • 111
    • 0033708398 scopus 로고    scopus 로고
    • Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor
    • GERBER HP, KOWALSKI J, SHERMAN D, EBERHARD DA, FERRARA N: Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. (2000) 60:6253-6258.
    • (2000) Cancer Res. , vol.60 , pp. 6253-6258
    • Gerber, H.P.1    Kowalski, J.2    Sherman, D.3    Eberhard, D.A.4    Ferrara, N.5
  • 112
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
    • BORGSTRÖM P, HILLAN KJ, SRIMARARAO P, FERRARA N: Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. (1996) 56:4032-4039.
    • (1996) Cancer Res. , vol.56 , pp. 4032-4039
    • Borgström, P.1    Hillan, K.J.2    Srimararao, P.3    Ferrara, N.4
  • 113
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an antivascular endothelial growth factor/vascular permeability factor antibody
    • YUAN F, CHEN Y, DELLIAN M et al.: Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an antivascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA (1996) 93:14765-14770.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3
  • 114
    • 0031719516 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in ovarian cancer. Inhibition of Ascites formation by immunoneutralization
    • MESIANO S, FERRARA N, JAFFE RB: Role of vascular endothelial growth factor in ovarian cancer. Inhibition of Ascites formation by immunoneutralization. Am. J. Pathol. (1998) 153:1249-1256.
    • (1998) Am. J. Pathol. , vol.153 , pp. 1249-1256
    • Mesiano, S.1    Ferrara, N.2    Jaffe, R.B.3
  • 115
    • 0032848409 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model
    • MELNYK O, ZIMMERMAN M, KIM KJ, SHUMAN M: Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model. J. Urol. (1999) 161:960-963.
    • (1999) J. Urol. , vol.161 , pp. 960-963
    • Melnyk, O.1    Zimmerman, M.2    Kim, K.J.3    Shuman, M.4
  • 116
    • 0032806309 scopus 로고    scopus 로고
    • Importance of VEGF for breast cancer angiogenesis in vivo implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin
    • BORGSTRÖM P, GOLD DP, HILLAN KJ, FERRARA N: Importance of VEGF for breast cancer angiogenesis in vivo implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res. (1999) 19:4203-4214.
    • (1999) Anticancer Res. , vol.19 , pp. 4203-4214
    • Borgström, P.1    Gold, D.P.2    Hillan, K.J.3    Ferrara, N.4
  • 117
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • LEE CG, HEIJN M, DI TOMASO E et al.: Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. (2000) 60:5565-5570.
    • (2000) Cancer Res. , vol.60 , pp. 5565-5570
    • Lee, C.G.1    Heijn, M.2    Di Tomaso, E.3
  • 118
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • BENJAMIN LE, GOLIJANIN D, ITIN A, PODE D, KESHET E: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. (1999) 103:159-165.
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 119
    • 0033564974 scopus 로고    scopus 로고
    • Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • GORSKI DH, BECKETT MA, JASKOWIAK NT et al.: Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. (1999) 59:3374-3378.
    • (1999) Cancer Res. , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3
  • 120
    • 0032979775 scopus 로고    scopus 로고
    • Preclinical safety evaluation of rhuMAbVEGF an antiangiogenic humanized monoclonal antibody
    • RYAN AM, BATES-EPPLER D, HAGLER KE et al.: Preclinical safety evaluation of rhuMAbVEGF an antiangiogenic humanized monoclonal antibody. Toxicol. Pathol. (1999) 27:78-86.
    • (1999) Toxicol. Pathol. , vol.27 , pp. 78-86
    • Ryan, A.M.1    Bates-eppler, D.2    Hagler, K.E.3
  • 121
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • GORDON MS, MARGOLIN K, TALPAZ M et al.: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J. Clin. Oncol. (2001) 19:843-850.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 122
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • MARGOLIN K, GORDON MS, HOLMGREN E et al.: Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data. J. Clin. Oncol. (2001) 19:851-856.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 851-856
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3
  • 123
    • 0003170893 scopus 로고    scopus 로고
    • A Phase II trial of single-agent RhumAb VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) in patients with relapsed metastatic breast cancer
    • SLEDGE G, MILLER K, NOVOTNY W et al.: A Phase II trial of single-agent RhumAb VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) in patients with relapsed metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. (2000) 19:5C.
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Sledge, G.1    Miller, K.2    Novotny, W.3
  • 124
    • 0003305378 scopus 로고    scopus 로고
    • Successful long-term therapy with bevacizumab (Avastin) in solid tumors
    • (Abstract 32)
    • LANGMUIR VK, COBLEIGH MA, HERBST RS et al.: Successful long-term therapy with bevacizumab (Avastin) in solid tumors. Proc. Am. Soc. Clin. Oncol. (2002) 21 (Abstract 32).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Langmuir, V.K.1    Cobleigh, M.A.2    Herbst, R.S.3
  • 125
    • 0001674315 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled trial of bevacizumab (anti-VEGF antibody) demonstrating a prolongation in time to progression in patients with metastatic renal cancer
    • (Abstract 15)
    • YANG JC, HAWORTH L, STEINBERG SM et al.: A randomized double-blind placebo-controlled trial of bevacizumab (anti-VEGF antibody) demonstrating a prolongation in time to progression in patients with metastatic renal cancer. Proc. Am. Soc. Clin. Oncol. (2002) 21 (Abstract 15).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Yang, J.C.1    Haworth, L.2    Steinberg, S.M.3
  • 126
    • 0001496152 scopus 로고    scopus 로고
    • Bevacizumab (BV) + chemotherapy (CT) may improve survival in metastatic colorectal cancer (MCRC) subjects with unfavorable prognostic indicators
    • BERGSLAND EK, FEHRENBACHER L, NOVOTNY W et al.: Bevacizumab (BV) + chemotherapy (CT) may improve survival in metastatic colorectal cancer (MCRC) subjects with unfavorable prognostic indicators. Proc. Am. Soc. Clin. Oncol. (2001) 20:2247.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 2247
    • Bergsland, E.K.1    Fehrenbacher, L.2    Novotny, W.3
  • 127
    • 0003250698 scopus 로고    scopus 로고
    • Carboplatin (C) + paclitaxel (T) + RhuMAb-VEGF (AVF) may prolong survival in advanced nonsquamous lung cancer
    • JOHNSON DH, DEVORE R, KABBINAVAR F et al.: Carboplatin (C) + paclitaxel (T) + RhuMAb-VEGF (AVF) may prolong survival in advanced nonsquamous lung cancer. Proc. Am. Soc. Clin. Oncol. (2001) 20:1256.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 1256
    • Johnson, D.H.1    Devore, R.2    Kabbinavar, F.3
  • 128
    • 0033043733 scopus 로고    scopus 로고
    • Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor
    • ASANO M, YUKITA A, SUZUKI H: Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor. Jpn. J. Cancer Res. (1999) 90:93-100.
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 93-100
    • Asano, M.1    Yukita, A.2    Suzuki, H.3
  • 129
    • 0001904635 scopus 로고    scopus 로고
    • Anti-VEGF antibody HuMV833:an EORTC biological treatment development group Phase I toxicity, pharmacokinetic and pharmacodynamic study
    • JAYSON GC, MULATERO C, RANSON M et al.: Anti-VEGF antibody HuMV833:an EORTC biological treatment development group Phase I toxicity, pharmacokinetic and pharmacodynamic study. Proc. Am. Soc. Clin. Oncol (2001) 20:14.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 14
    • Jayson, G.C.1    Mulatero, C.2    Ranson, M.3
  • 130
    • 0032962388 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody
    • ZHU Z, LU D, KOTANIDES H et al.: Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody. Cancer Lett. (1999) 136:203-213.
    • (1999) Cancer Lett. , vol.136 , pp. 203-213
    • Zhu, Z.1    Lu, D.2    Kotanides, H.3
  • 131
    • 0034640422 scopus 로고    scopus 로고
    • Identification of the residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies
    • LU D, KUSSIE P, PYTOWSKI B et al.: Identification of the residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies. J. Biol. Chem. (2000) 275:14321-14330.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14321-14330
    • Lu, D.1    Kussie, P.2    Pytowski, B.3
  • 132
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • PREWETT M, HUBER J, LI Y et al.: Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. (1999) 59:5209-5218.
    • (1999) Cancer Res. , vol.59 , pp. 5209-5218
    • Prewett, M.1    Huber, J.2    Li, Y.3
  • 133
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • KLEMENT G, BARUCHEL S, RAK J et al.: Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. (2000) 105:R15-R24.
    • (2000) J. Clin. Invest. , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 134
    • 0035132923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
    • KOZIN SV, BOUCHER Y, HICKLIN DJ, BOHLEN P, JAIN RK, SUIT HD: Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. (2001) 61:39-44.
    • (2001) Cancer Res. , vol.61 , pp. 39-44
    • Kozin, S.V.1    Boucher, Y.2    Hicklin, D.J.3    Bohlen, P.4    Jain, R.K.5    Suit, H.D.6
  • 135
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • RUBENSTEIN JL, KIM J, OZAWA T et al.: Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia (2000) 4:306-314.
    • (2000) Neoplasia , vol.4 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3
  • 136
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioblastoma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • KUNKEL P, ULBRICHT U, BOHLEN P et al.: Inhibition of glioblastoma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res. (2001) 61:6624-6628.
    • (2001) Cancer Res. , vol.61 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohlen, P.3
  • 137
    • 0035866775 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: Role of VEGF-receptor 2 and host VEGF-A
    • KADAMBI A, CARREIRA CM, YUN CO et al.: Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Res. (2001) 61:2404-2408.
    • (2001) Cancer Res. , vol.61 , pp. 2404-2408
    • Kadambi, A.1    Carreira, C.M.2    Yun, C.O.3
  • 138
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • MILLAUER B, SHAWVER LK, PLATE KH, RISAU W, ULLRICH A: Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (1994) 367:576-579.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 139
    • 0033168947 scopus 로고    scopus 로고
    • Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA
    • PARRY TJ, CUSHMAN C, GALLEGOS AM et al.: Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. (1999) 27:2569-2577.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2569-2577
    • Parry, T.J.1    Cushman, C.2    Gallegos, A.M.3
  • 140
    • 0034069028 scopus 로고    scopus 로고
    • Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
    • PAVCO PA, BOUHANA KS, GALLEGOS AM et al.: Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin. Cancer Res. (2000) 6:2094-2103.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2094-2103
    • Pavco, P.A.1    Bouhana, K.S.2    Gallegos, A.M.3
  • 142
    • 6744226349 scopus 로고    scopus 로고
    • Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey
    • SANDBERG JA, SPROUL CD, BLANCHARD KS et al.: Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey. Antisense Nucleic Acid Drug Dev. (2000) 10:153-162.
    • (2000) Antisense Nucleic Acid Drug Dev. , vol.10 , pp. 153-162
    • Sandberg, J.A.1    Sproul, C.D.2    Blanchard, K.S.3
  • 143
    • 0033750282 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers
    • SANDBERG JA, PARKER VP, BLANCHARD KS et al.: Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers. J. Clin. Pharmacol. (2000) 40:1462-1469.
    • (2000) J. Clin. Pharmacol. , vol.40 , pp. 1462-1469
    • Sandberg, J.A.1    Parker, V.P.2    Blanchard, K.S.3
  • 144
    • 0035290919 scopus 로고    scopus 로고
    • Angiozyme: A novel angiogenesis inhibitor
    • WENG DE, USMAN N: Angiozyme: a novel angiogenesis inhibitor. Curr. Oncol. Rep. (2000) 3:141-146.
    • (2000) Curr. Oncol. Rep. , vol.3 , pp. 141-146
    • Weng, D.E.1    Usman, N.2
  • 145
    • 0000679268 scopus 로고    scopus 로고
    • Angiozyme pharmacokinetic and safety results: A Phase i/ii study in patients with refractory solid tumors
    • (Abstract)
    • WENG DE, WEISS P, KELLACKEY C et al.: Angiozyme pharmacokinetic and safety results: a Phase i/ii study in patients with refractory solid tumors. Proc. Am. Soc. Clin. Oncol. (2001):393 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , pp. 393
    • Weng, D.E.1    Weiss, P.2    Kellackey, C.3
  • 146
    • 0034007818 scopus 로고    scopus 로고
    • Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids
    • HORNIG C, BARLEON B, AHMAD S et al.: Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids. Lab. Invest. (2000) 80(4):443-454.
    • (2000) Lab. Invest. , vol.80 , Issue.4 , pp. 443-454
    • Hornig, C.1    Barleon, B.2    Ahmad, S.3
  • 147
    • 0035036554 scopus 로고    scopus 로고
    • Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-1, in fluid samples: Development and application of two new immunoassays
    • BELGORE FM, BLANN AD, LIP GY: Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-1, in fluid samples: development and application of two new immunoassays. Clin. Sci. (2001) 100(5):567-575.
    • (2001) Clin. Sci. , vol.100 , Issue.5 , pp. 567-575
    • Belgore, F.M.1    Blann, A.D.2    Lip, G.Y.3
  • 148
    • 0035059209 scopus 로고    scopus 로고
    • Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1)
    • SHIBUYA M: Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1). Int. J. Biochem. Cell Biol. (2001) 33(4):409-420.
    • (2001) Int. J. Biochem. Cell Biol. , vol.33 , Issue.4 , pp. 409-420
    • Shibuya, M.1
  • 149
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • GERBER HP, VU TH, RYAN AM et al.: VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. (1999) 5:623-628.
    • (1999) Nat. Med. , vol.5 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3
  • 150
    • 0031940839 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for corpus luteum angiogenesis
    • FERRARA N, CHEN H, DAVIS-SMYTH T et al.: Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat. Med. (1998) 4(3):336-340.
    • (1998) Nat. Med. , vol.4 , Issue.3 , pp. 336-340
    • Ferrara, N.1    Chen, H.2    Davis-smyth, T.3
  • 151
    • 0031965353 scopus 로고    scopus 로고
    • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor
    • LIN P, SANKAR S, SHAN S et al.: Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ. (1998) 9(1):49-58.
    • (1998) Cell Growth Differ. , vol.9 , Issue.1 , pp. 49-58
    • Lin, P.1    Sankar, S.2    Shan, S.3
  • 152
    • 0035836697 scopus 로고    scopus 로고
    • Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer
    • KUO CJ, FARNEBO F, YU EY et al.: Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc. Natl. Acad. Sci. USA (2001) 98(8):4605-4610.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.8 , pp. 4605-4610
    • Kuo, C.J.1    Farnebo, F.2    Yu, E.Y.3
  • 153
    • 0032987760 scopus 로고    scopus 로고
    • Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design
    • COLE PA, SONDHI D, KIM K: Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design. Pharmacol. Ther. (1999) 82:219-229.
    • (1999) Pharmacol. Ther. , vol.82 , pp. 219-229
    • Cole, P.A.1    Sondhi, D.2    Kim, K.3
  • 154
    • 12244277954 scopus 로고    scopus 로고
    • Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
    • MENDEL DB, LAIRD AD, SMOLICH BD et al.: Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anti-Cancer Drug Design (2000) 15:29-41.
    • (2000) Anti-Cancer Drug Design , vol.15 , pp. 29-41
    • Mendel, D.B.1    Laird, A.D.2    Smolich, B.D.3
  • 156
    • 0027170386 scopus 로고
    • Cinnamamide analogs as inhibitors of protein tyrosine kinases
    • BUZZETTI F, BRASCA MG, CRUGNOLA A et al.: Cinnamamide analogs as inhibitors of protein tyrosine kinases. Farmaco (1993) 48:615-636.
    • (1993) Farmaco , vol.48 , pp. 615-636
    • Buzzetti, F.1    Brasca, M.G.2    Crugnola, A.3
  • 157
    • 0034644272 scopus 로고    scopus 로고
    • Identification of substituted 3-[(4,5,6,7-tetrahydro-1 H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-R.β tyrosine kinases
    • SUN L, TRAN H, LIANG C et al.: Identification of substituted 3-[(4,5,6,7-tetrahydro-1 H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-R.β tyrosine kinases. J. Med. Chem. (2000) 43:2655-2663.
    • (2000) J. Med. Chem. , vol.43 , pp. 2655-2663
    • Sun, L.1    Tran, H.2    Liang, C.3
  • 158
    • 0032474915 scopus 로고    scopus 로고
    • Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases
    • SUN L, TRAN N, TANG F et al.: Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J. Med. Chem. (1998) 41:2588-2603.
    • (1998) J. Med. Chem. , vol.41 , pp. 2588-2603
    • Sun, L.1    Tran, N.2    Tang, F.3
  • 159
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • LAIRD AD, VAJKOCZY P, SHAWVER LK et al.: SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. (2000) 60:4152-4160.
    • (2000) Cancer Res. , vol.60 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3
  • 160
    • 0035328851 scopus 로고    scopus 로고
    • Indolinone tyrosine kinase inhibitors block Kit activation and growth of small-cell lung cancer cells
    • KRYSTAL GW, HONSAWEK S, KIEWLICH D et al.: Indolinone tyrosine kinase inhibitors block Kit activation and growth of small-cell lung cancer cells. Cancer Res. (2001) 61:3660-3668.
    • (2001) Cancer Res. , vol.61 , pp. 3660-3668
    • Krystal, G.W.1    Honsawek, S.2    Kiewlich, D.3
  • 161
    • 0242445559 scopus 로고    scopus 로고
    • Prospects for anti-angiogenic therapies based upon VEGF inhibition
    • I Ojima, G Vite, K Altmann (Eds) ACS Symposium Series 796, American Chemical Society, Washington DC
    • MANLEY PW, FURET P: Prospects for anti-angiogenic therapies based upon VEGF inhibition. In: ACS Volume. Anti-Cancer Agents. Frontiers in Cancer Chemotherapy. I Ojima, G Vite, K Altmann (Eds) ACS Symposium Series 796, American Chemical Society, Washington DC (2001):282-298.
    • (2001) ACS Volume. Anti-Cancer Agents. Frontiers in Cancer Chemotherapy , pp. 282-298
    • Manley, P.W.1    Furet, P.2
  • 162
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation and growth of multiple tumor types
    • FONG TAT, SHAWVER LK, SUN L et al.: SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation and growth of multiple tumor types. Cancer Res. (1999) 59:99-106.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.T.1    Shawver, L.K.2    Sun, L.3
  • 163
    • 0033107767 scopus 로고    scopus 로고
    • Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multifluorescence videomicroscopy
    • VAJKOCZY P, MENGER MD, VOLLMAR B et al.: Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multifluorescence videomicroscopy. Neoplasia (1999) 1:31-41.
    • (1999) Neoplasia , vol.1 , pp. 31-41
    • Vajkoczy, P.1    Menger, M.D.2    Vollmar, B.3
  • 164
    • 0034661728 scopus 로고    scopus 로고
    • Targeting angiogenesis inhibits tumor infiltration and expression of the proinvasive protein SPARC
    • VAJKOCZY P, MENGER MD, GOLDBRUNNER R et al.: Targeting angiogenesis inhibits tumor infiltration and expression of the proinvasive protein SPARC. Int. J. Cancer (2000) 87:261-268.
    • (2000) Int. J. Cancer , vol.87 , pp. 261-268
    • Vajkoczy, P.1    Menger, M.D.2    Goldbrunner, R.3
  • 165
    • 0033231069 scopus 로고    scopus 로고
    • Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induced tumor and endothelial cell apoptosis
    • SHAHEEN RM, DAVIS DW, LIU W et al.: Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induced tumor and endothelial cell apoptosis. Cancer Res. (1999) 59:5412-5416.
    • (1999) Cancer Res. , vol.59 , pp. 5412-5416
    • Shaheen, R.M.1    Davis, D.W.2    Liu, W.3
  • 166
    • 0033229939 scopus 로고    scopus 로고
    • Inhibition of Angiogenesis by Blocking Activation of the Vascular Endothelial Growth Factor Receptor 2 Leads to Decreased Growth of Neurogenic Sarcomas
    • ANGELOV L, SALHIA B, RONCARI L et al.: Inhibition of Angiogenesis by Blocking Activation of the Vascular Endothelial Growth Factor Receptor 2 Leads to Decreased Growth of Neurogenic Sarcomas. Cancer Res. (1999) 59:5536-5541.
    • (1999) Cancer Res. , vol.59 , pp. 5536-5541
    • Angelov, L.1    Salhia, B.2    Roncari, L.3
  • 167
    • 0037087585 scopus 로고    scopus 로고
    • Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients with Solid Tumors
    • KUENEN BC, ROSEN L, SMIT EF et al.: Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients with Solid Tumors. J. Clin. Oncol. (2002) 20:1657-1667.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1657-1667
    • Kuenen, B.C.1    Rosen, L.2    Smit, E.F.3
  • 168
    • 0033669345 scopus 로고    scopus 로고
    • Biotransformation of the antiangiogenic compound SU5416
    • ANTONIAN L, ZHANG H, YANG C et al.: Biotransformation of the antiangiogenic compound SU5416. Drug Metab. Dispos. (2000) 28:1505-1512.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1505-1512
    • Antonian, L.1    Zhang, H.2    Yang, C.3
  • 169
    • 0003037701 scopus 로고    scopus 로고
    • A Phase I/II Study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer
    • (Abstract)
    • ROSEN PJ, AMADO R, HECHT JR et al.: A Phase I/II Study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 389
    • Rosen, P.J.1    Amado, R.2    Hecht, J.R.3
  • 170
    • 0035282940 scopus 로고    scopus 로고
    • The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
    • SMOLICH BD, YUEN HA, WEST KA et al.: The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood (2001) 97:1413-1421.
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.D.1    Yuen, H.A.2    West, K.A.3
  • 171
    • 0035412371 scopus 로고    scopus 로고
    • Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia
    • MESTERS RM, PADRO T, BIEKER R et al.: Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia. Blood (2001) 98:241-243.
    • (2001) Blood , vol.98 , pp. 241-243
    • Mesters, R.M.1    Padro, T.2    Bieker, R.3
  • 172
    • 0033996775 scopus 로고    scopus 로고
    • Von Hippel-Lindau syndrome: Target for anti-vascular endothelial growth factor (VEGF) receptor therapy
    • HARRIS AL: Von Hippel-Lindau syndrome: target for anti-vascular endothelial growth factor (VEGF) receptor therapy. Oncologist (2000) 5:32-36.
    • (2000) Oncologist , vol.5 , pp. 32-36
    • Harris, A.L.1
  • 173
    • 0002647522 scopus 로고    scopus 로고
    • Phase I experience with oral SU006668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies
    • Amsterdam, NL (Abstract)
    • ROSEN L, HANNAH A, ROSEN P et al.: Phase I experience with oral SU006668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies. 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, Amsterdam, NL (2000):581 (Abstract).
    • (2000) 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy , pp. 581
    • Rosen, L.1    Hannah, A.2    Rosen, P.3
  • 174
    • 0000103504 scopus 로고    scopus 로고
    • Phase I experience with SU6668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies
    • (Abstract)
    • ROSEN LS, ROSEN PJ, KABBINAVAR F et al.: Phase I experience with SU6668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies. Proc. Am. Soc. Clin. Oncol. (2001) 20:383 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 383
    • Rosen, L.S.1    Rosen, P.J.2    Kabbinavar, F.3
  • 175
    • 0000223717 scopus 로고    scopus 로고
    • Inhibition of Kit-positive SCLC growth by SU11248, a novel tyrosine kinase inhibitor
    • 93rd Annual Meeting of the AACR Symposium on Molecular Targets and Cancer Therapeutics, San Francisco, CA, USA (Abstract)
    • ABRAMS TJ, LEE LB, MURRAY LJ, MENDEL DB, CHERRINGTON JM: Inhibition of Kit-positive SCLC growth by SU11248, a novel tyrosine kinase inhibitor. 93rd Annual Meeting of the AACR Symposium on Molecular Targets and Cancer Therapeutics, San Francisco, CA, USA (2002):1669 (Abstract).
    • (2002) , pp. 1669
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Mendel, D.B.4    Cherrington, J.M.5
  • 176
    • 0033947625 scopus 로고    scopus 로고
    • New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis
    • BOLD G, ALTMANN KH, FREI J et al.: New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J. Med. Chem. (2000) 43:2310-2323.
    • (2000) J. Med. Chem. , vol.43 , pp. 2310-2323
    • Bold, G.1    Altmann, K.H.2    Frei, J.3
  • 177
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • WOOD JM, BOLD G, BUCHDUNGER E et al.: PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. (2000) 60:2178-2189.
    • (2000) Cancer Res. , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 178
    • 0034016273 scopus 로고    scopus 로고
    • Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation
    • YANO S, HERBST RS, SHINOHARA H et al.: Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation. J. Clin. Cancer Res. (2000) 6:957-965.
    • (2000) J. Clin. Cancer Res. , vol.6 , pp. 957-965
    • Yano, S.1    Herbst, R.S.2    Shinohara, H.3
  • 179
    • 0035555907 scopus 로고    scopus 로고
    • Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth
    • HESS C, VUONG V, HEGYL I et al.: Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth. Br. J. Cancer (2001) 85:2010-2016.
    • (2001) Br. J. Cancer , vol.85 , pp. 2010-2016
    • Hess, C.1    Vuong, V.2    Hegyl, I.3
  • 180
    • 0033882794 scopus 로고    scopus 로고
    • Blockade of VEGF receptor signaling is sufficient to completely prevent retinal neovascularization
    • OZAKI H, SEO M, OZAKI K et al.: Blockade of VEGF receptor signaling is sufficient to completely prevent retinal neovascularization. Am. J. Pathol. (2000) 156:697-707.
    • (2000) Am. J. Pathol. , vol.156 , pp. 697-707
    • Ozaki, H.1    Seo, M.2    Ozaki, K.3
  • 182
    • 0001341494 scopus 로고    scopus 로고
    • A Phase-1 dose-escalating and pharmacokinetic (PK) study of the VEGF-receptor-inhibitor PTK787/ZK222584 (PTK/ZK) in patients with liver metastasis of advanced cancer
    • (Abstract)
    • DREVS J, MROSS K, FUXIUS S et al.: A Phase-1 dose-escalating and pharmacokinetic (PK) study of the VEGF-receptor-inhibitor PTK787/ZK222584 (PTK/ZK) in patients with liver metastasis of advanced cancer. Proc. Am. Soc. Clin. Oncol. (2001) 20:398 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 398
    • Drevs, J.1    Mross, K.2    Fuxius, S.3
  • 183
    • 0001432917 scopus 로고    scopus 로고
    • Pharmacodynamic results using dynamic contrast enhanced magnetic resonance imaging, of 2 Phase I studies of the VEGF inhibitor PTK787/ZK 222584 in Patients with Liver Metastases from Colorectal Cancer
    • (Abstract)
    • THOMAS A, MORGON B, DREVS J et al.: Pharmacodynamic results using dynamic contrast enhanced magnetic resonance imaging, of 2 Phase I studies of the VEGF inhibitor PTK787/ZK 222584 in Patients with Liver Metastases from Colorectal Cancer. Proc. Am. Soc. Clin. Oncol. (2001) 20:279 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 279
    • Thomas, A.1    Morgon, B.2    Drevs, J.3
  • 184
    • 0037075812 scopus 로고    scopus 로고
    • Novel 4-anilinoquinazolines with C-7 basic side chains: Design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    • HENNEQUIN LF, STOKES ES, THOMAS AP et al.: Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J. Med. Chem. (2002) 45:1300-1312.
    • (2002) J. Med. Chem. , vol.45 , pp. 1300-1312
    • Hennequin, L.F.1    Stokes, E.S.2    Thomas, A.P.3
  • 185
    • 17544387877 scopus 로고    scopus 로고
    • Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors
    • HENNEQUIN LF, THOMAS AP, JOHNSTONE C et al.: Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J. Med. Chem. (1999) 42:5369-5389.
    • (1999) J. Med. Chem. , vol.42 , pp. 5369-5389
    • Hennequin, L.F.1    Thomas, A.P.2    Johnstone, C.3
  • 186
    • 0034652716 scopus 로고    scopus 로고
    • ZD4190:an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy
    • WEDGE SR, OGILVIE DJ, DUKES M et al.: ZD4190:an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res. (2000) 60:970-975.
    • (2000) Cancer Res. , vol.60 , pp. 970-975
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 187
    • 0001725212 scopus 로고    scopus 로고
    • VEGF Receptor tyrosine kinase inhibitors as potential anti-tumour agents
    • (Abstract)
    • WEDGE SR, OGILVIE DJ, DUKES M et al.: VEGF Receptor tyrosine kinase inhibitors as potential anti-tumour agents. Proc. Am. Assoc. Cancer Res. (2000) 41:3610 (Abstract).
    • (2000) Proc. Am. Assoc. Cancer Res. , vol.41 , pp. 3610
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 188
    • 0003286456 scopus 로고    scopus 로고
    • The VEGF receptor tyrosine kinase inhibitor ZD6474 is efficacious in a spontaneously metastatic human tumor model
    • Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications (Abstract)
    • WEDGE SR, KENDREW J, KLINOWSKA T et al.: The VEGF receptor tyrosine kinase inhibitor ZD6474 is efficacious in a spontaneously metastatic human tumor model. Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications. Clin. Cancer Res. (2001) 7(Suppl.):4 (Abstract).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.SUPPL. , pp. 4
    • Wedge, S.R.1    Kendrew, J.2    Klinowska, T.3
  • 189
    • 0001531722 scopus 로고    scopus 로고
    • Dynamic Contrast-enhanced MRI Study of Human Tumor Xenografts Treated with the VEGF Signalling Inhibitor ZD6474
    • (Abstract)
    • WEDGE SR, CHECKLY D, DUKES M et al.: Dynamic Contrast-enhanced MRI Study of Human Tumor Xenografts Treated with the VEGF Signalling Inhibitor ZD6474. Proc. Am. Assoc. Cancer Res. (2001) 42:581 (Abstract).
    • (2001) Proc. Am. Assoc. Cancer Res. , vol.42 , pp. 581
    • Wedge, S.R.1    Checkly, D.2    Dukes, M.3
  • 190
    • 0003216909 scopus 로고    scopus 로고
    • Pharmacological Efficacy of ZD6474, a VEGF Receptor Tyrosine Kinase Inhibitor, in Rat
    • (Abstract)
    • WEDGE SR, OGILVIE DJ, DUKES M et al.: Pharmacological Efficacy of ZD6474, a VEGF Receptor Tyrosine Kinase Inhibitor, in Rat. Proc. Am. Assoc. Cancer Res. (2001) 42:3126 (Abstract).
    • (2001) Proc. Am. Assoc. Cancer Res. , vol.42 , pp. 3126
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 191
    • 0000705695 scopus 로고    scopus 로고
    • A Phase I study of ZD6474, an oral VEGF receptor tyrosine kinase inhibitor, in patients with solid tumors
    • Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications (Abstract)
    • HURWITZ HI, ECKHARDT SG, HOLDEN SN et al.: A Phase I study of ZD6474, an oral VEGF receptor tyrosine kinase inhibitor, in patients with solid tumors. Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications. Clin. Cancer Res. (2001) 7(Suppl.):5 (Abstract).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.SUPPL. , pp. 5
    • Hurwitz, H.I.1    Eckhardt, S.G.2    Holden, S.N.3
  • 192
    • 0000162958 scopus 로고    scopus 로고
    • Phase I Pharmacokinetic and Biological Study of the Angiogenesis Inhibitor, ZD6474, in Patients with Solid Tumors
    • (Abstract)
    • HURWITZ HI, ECKHARDT SG, HOLDEN SN et al.: Phase I Pharmacokinetic and Biological Study of the Angiogenesis Inhibitor, ZD6474, in Patients with Solid Tumors. Proc. Am. Soc. Clin. Oncol. (2001) 20:396 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 396
    • Hurwitz, H.I.1    Eckhardt, S.G.2    Holden, S.N.3
  • 193
    • 0001048324 scopus 로고    scopus 로고
    • CEP-7055:An orally-active VEGF-R kinase inhibitor with potent anti-angiogenic activity and anti-tumor efficacy against human tumor xenograft growth
    • (Abstract)
    • RUGGERI BA, SINGH J, HUDKINS R et al.: CEP-7055:An orally-active VEGF-R kinase inhibitor with potent anti-angiogenic activity and anti-tumor efficacy against human tumor xenograft growth. Proc. Am. Assoc. Cancer Res. (2002) 43:5347 (Abstract).
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 5347
    • Ruggeri, B.A.1    Singh, J.2    Hudkins, R.3
  • 194
    • 0012146783 scopus 로고    scopus 로고
    • CEP-5214, a novel orally active inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase and prostate tumor growth in vivo
    • Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications. (Abstract)
    • PILI R, ROBINSON C, MORRIS C, DIONNE CA, ISAACS JT, RUGGERI BA: CEP-5214, a novel orally active inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase and prostate tumor growth in vivo. Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications. Clin. Cancer Res. (2001) 7(Suppl.):27 (Abstract).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.SUPPL. , pp. 27
    • Pili, R.1    Robinson, C.2    Morris, C.3    Dionne, C.A.4    Isaacs, J.T.5    Ruggeri, B.A.6
  • 195
    • 0001511008 scopus 로고    scopus 로고
    • The effects of the orally-active VEGF-R kinase inhibitor, CEP-7055, on primary tumor growth and metastatic profile in orthotopic models of human pancreatic ductal carcinoma and murine renal carcinoma (RENCA) in mice
    • JONES-BOLIN S, HUNTER K, ZHAO B, RUGGERI BA: The effects of the orally-active VEGF-R kinase inhibitor, CEP-7055, on primary tumor growth and metastatic profile in orthotopic models of human pancreatic ductal carcinoma and murine renal carcinoma (RENCA) in mice. Proc. Am. Assoc. Cancer Res. (2002) 43:2601.
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 2601
    • Jones-bolin, S.1    Hunter, K.2    Zhao, B.3    Ruggeri, B.A.4
  • 196
    • 0002508125 scopus 로고    scopus 로고
    • Preliminary pharmacokinetic (PK) characteristics of an oral vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor (TKI), CP-547,632 in patients (pts) with advanced solid tumors
    • (Abstract)
    • KARP DD, TOLCHER A, HEALEY D et al.: Preliminary pharmacokinetic (PK) characteristics of an oral vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor (TKI), CP-547,632 in patients (pts) with advanced solid tumors. Proc. Am. Assoc. Cancer Res. (2002) 43:2753 (Abstract).
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 2753
    • Karp, D.D.1    Tolcher, A.2    Healey, D.3
  • 197
    • 0012108360 scopus 로고    scopus 로고
    • Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR
    • MEDI-147
    • BILODEAU MT, COLL KE, CUNNINGHAM AM et al.: Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR. Abstr. Pap. Am. Chem. Soc. (2001) 221:MEDI-147.
    • (2001) Abstr. Pap. Am. Chem. Soc. , vol.221
    • Bilodeau, M.T.1    Coll, K.E.2    Cunningham, A.M.3
  • 198
    • 0012184990 scopus 로고    scopus 로고
    • BIBF1000:A novel and potent VEGFR-2 inhibitor inhibits proliferation and induces apoptosis of endothelial cells in vitro
    • Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications. (Abstract)
    • HELL-POURMOJIB M, HILBERG F, HECKEL A, VAN MEEL J: BIBF1000:A novel and potent VEGFR-2 inhibitor inhibits proliferation and induces apoptosis of endothelial cells in vitro. Proceedings of the 12th AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics, Discovery, Biology, and Clinical Applications. Clin. Cancer Res. (2001) 7(Suppl.):23 (Abstract).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.SUPPL. , pp. 23
    • Hell-pourmojib, M.1    Hilberg, F.2    Heckel, A.3    Van Meel, J.4
  • 199
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to anti-angiogenic therapy
    • YU JL, RAK JW, COOMBER BL et al.: Effect of p53 status on tumor response to anti-angiogenic therapy. Science (2002) 295:156-158.
    • (2002) Science , vol.295 , pp. 156-158
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.