Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design

Pharmacology and Therapeutics

Volumn 82, Issue 2-3, 1999, Pages 219-229

  Cole, Philip A ^a   Sondhi, Dolan ^a   Kim, Kyonghee ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Expressed protein ligation; Inhibition; Mechanism; Protein kinases; Selectivity; Transition state

Indexed keywords

FLUOROTYROSINE DERIVATIVE; PEPTIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT PROTEIN; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

CARBOXY TERMINAL SEQUENCE; CHEMICAL REACTION KINETICS; CONFERENCE PAPER; DRUG DESIGN; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC ENGINEERING; LIGAND BINDING; PHOSPHORYLATION; PRIORITY JOURNAL; PROTON TRANSPORT; SIGNAL TRANSDUCTION; TECHNIQUE;

CHEMISTRY, PHARMACEUTICAL; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEINS; SRC-FAMILY KINASES;

EID: 0032987760     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(98)00046-1     Document Type: Conference Paper

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