Indolinone tyrosine kinase inhibitors block kit activation and growth of small cell lung cancer cells

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3660-3668

  Krystal, Geoffrey W ^a   Honsawek, Sittisak ^a   Kiewlich, David ^b   Liang, Congxin ^b   Vasile, Stefan ^b   Sun, Li ^b   McMahon, Gerald ^b   Lipson, Kenneth E ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 3 [(4,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; ADENOSINE TRIPHOSPHATE; INDOLE DERIVATIVE; PROPIONIC ACID; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C; STEM CELL FACTOR; SU 5614; SU 6561; SU 6597; SU 6663; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; BIOCHEMISTRY; CANCER INHIBITION; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME ASSAY; ENZYME INHIBITOR INTERACTION; GROWTH REGULATION; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARCINOMA, SMALL CELL; CELL DIVISION; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GROWTH INHIBITORS; HUMANS; INDOLES; LUNG NEOPLASMS; MODELS, MOLECULAR; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; PYRROLES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; STEM CELL FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035328851     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

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