Genetics: A touch of elegance with RNAi

Current Biology

Volumn 9, Issue 12, 1999, Pages

  Hunter, Craig P ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION REGULATION; GENE FUNCTION; RNA;

CAENORHABDITIS ELEGANS;

EID: 0033578071     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80276-0     Document Type: Note

References (20)

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditiselegans. Nature 1998, 391:806-811.
2. Kennerdell JR, Carthew RW: Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 1998, 95:1017-1026.
3. Misquitta L, Paterson BM: Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation. Proc Natl Acad Sci USA 1999, 96:1451-1456.
4. Ngo H, Tschudi C, Gull K, Ullu E: Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc Natl Acad Sci USA 1998, 95:14687-14692.
5. Waterhouse PM, Graham MW, Wang M: Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA. Proc Natl Acad Sci USA 1998, 95:13959-13964.
6. Quo S, Kemphues, KJ: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/ Thr kinase that is asymmetrically distributed. Cell 1995, 81:611-620.
7. Montgomery MK, Fire A: Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression. Trends Genet 1998, 14:255-258
8. Timmons L, Fire A: Specific interference by ingested dsRNA. Nature 1998, 395:854.
9. Montgomery MK, Xu S, Fire A: RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc Natl Acad Sci USA 1998, 95:15502-15507.
10. Clark SG, Lu X, Horvitz HR: The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics 1994, 137:987-997.
11. Huang LS, Tzou P, Sternberg PW: The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell 1994, 5395-412.
12. Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH, Ali M, Priess JR, Mello CC: Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 1997, 90:707-716
13. Quo S, Kemphues KJ: A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature 1996, 382:455-458
14. Shi Y, Mello C : A CBP/ p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev 1998, 12:943-955.
15. Powers J, Bossinger O, Rose D, Strome S, Saxton W: Anematode kinesin required for cleavage furrow advancement. Curr Biol 1998, 8:1133-1136.
16. Skop AR, White JG : The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Curr Biol 1998, 8:1110-1116.
17. Powell-Coffman JA, Knight J, Wood WB: Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Dev Biol 1996, 178:472-483.
18. Hunter CP, Kenyon C: Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell 1996, 87:217-226.
19. Bhat MA, Izaddoost S, Lu Y, Cho K, Choi K, Bellen HJ: Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 1999, 96:833-845.
20. Alvarado AS, Newmark PA: Double-stranded RNA specifically disrupts gene expression during planarian regeneration. Proc Natl Acad Sci USA 1999, 96:5049-5054.