Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage

EMBO Reports

Volumn 1, Issue 4, 2000, Pages 347-352

  Stöven, Svenja ^a   Ando, Istvan ^a,c   Kadalayil, Latha ^b   Engström, Ylva ^b   Hultmark, Dan ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DROSOPHILA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSECT PROTEIN; RELISH PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; DROSOPHILA MELANOGASTER; GENE; GENE EXPRESSION; METABOLISM; SERODIAGNOSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CASPASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION; GENES, INSECT; INSECT PROTEINS; NF-KAPPA B; PRECIPITIN TESTS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034303480     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd072     Document Type: Article

References (14)

1. Chan, Y.-M. and Jan, Y.N. (1998) Roles for proteolysis and trafficking in Notch maturation and signal transduction. Cell, 94, 423-426.
2. Chen, P., Rodriguez, A., Erskine, R., Thach, T. and Abrams, J.M. (1998) Dredd, a novel effector of the apoptosis activators Reaper, Grim and Hid in Drosophila. Dev. Biol., 201, 202-216.
3. Dushay, M.S., Åsling, B. and Hultmark, D. (1996) Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl Acad. Sci. USA, 93, 10343-10347.
4. Edwards, D.N., Towb, P. and Wasserman, S.A. (1997) An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development, 124, 3855-3864.
5. Elrod-Erickson, M., Mishra, S. and Schneider, D. (2000) Interactions between the cellular and humoral immune responses in Drosophila. Curr. Biol., 10, 781-784.
6. Engström, Y., Kadalayil, L., Sun, S.-C., Samakovlis, C., Hultmark, D. and Faye, I. (1993) κB-like motifs regulate the induction of immune genes in Drosophila. J. Mol. Biol., 232, 327-333.
7. Gateff, E., Gissmann, L., Shrestha, R., Plus, N., Pfister, H., Schröder, J. and zur Hausen, H. (1980) Characterization of two tumorous blood cell lines of Drosophila melanogaster and the viruses they contain. In Kurstak, E., Maramorosch, K. and Dübendorfer, A. (eds), Invertebrate Systems In Vitro. Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands, pp. 517-533.
8. Ghosh, S., May, M.J. and Kopp, E.B. (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol., 16, 225-260.
9. Rorth, P. et al. (1998) Systematic gain-of-function genetics in Drosophila. Development, 125, 1049-1057.
10. Rutschmann, S., Jung, A.C., Hetru, C., Reichhart, J.-M., Hoffmann, J.A. and Ferrandon, D. (2000a) The Rel protein DIP mediates the antifungal, but not the antibacterial, host defense in Drosophila. Immunity, 12, 569-580.
11. Rutschmann, S., Jung, A.C., Zhou, R., Silverman, N., Hoffmann, J.A. and Ferrandon, D. (2000b) Role of Drosophila IKKγ in a Toll-independent antibacterial immune response. Nature Immunol, in press.
12. Samakovlis, C., Åsling, B., Boman, H.G., Gateff, E. and Hultmark, D. (1992) In vitro induction of cecropin genes - an immune response in a Drosophila blood cell line. Biochem. Biophys. Res. Commun., 188, 1169-1175.
13. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
14. Silverman, N., Zhou, R., Stöven, S., Pandey, N., Hultmark, D. and Maniatis, T. (2000) A Drosophilia IκB kinase complex required for Relish endoproteolysis and antibacterial immunity. Genes Dev., in press.