Intracellular vs extracellular recognition of pathogens - Common concepts in mammals and flies

Trends in Microbiology

Volumn 10, Issue 4, 2002, Pages 193-199

  Girardin, Stephen E ^a   Sansonetti, Philippe J ^a   Philpott, Dana J ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOPLASM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; LEUCINE; NUCLEOTIDE BINDING PROTEIN; PROTEIN NOD1; RECEPTOR SUBTYPE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BACTERIAL INFECTION; BINDING SITE; DROSOPHILA; GENETIC CONSERVATION; GRAM NEGATIVE BACTERIUM; IMMUNE RESPONSE; INFECTION; MICROBIAL DIVERSITY; MICROBIAL IDENTIFICATION; MICROBIAL IMMUNITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSOR; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BACTERIA; BACTERIAL INFECTIONS; CARRIER PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FUNGI; HUMANS; IMMUNITY, NATURAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE GLYCOPROTEINS; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTORS;

ANIMALIA; ARACHNIDA; BACTERIA (MICROORGANISMS); HEXAPODA; MAMMALIA; NEGIBACTERIA;

EID: 0036532316     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-842X(02)02334-X     Document Type: Review

References (65)

1. The instructive role of innate immunity in the acquired immune response
2. An ancient system of host defense
3. Molecular evolution of the vertebrate immune system
4. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
5. The Toll receptor family and microbial recognition
6. Toll, a new piece in the puzzle of innate immunity
7. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
8. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2
9. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
10. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
11. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB
12. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
13. Human Nod1 confers responsiveness to bacterial lipopolysaccharides
14. CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
15. Plant pathogens and integrated defence responses to infection
16. Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product
17. Genes that fight infection: What the Drosophila genome says about animal immunity
18. Getting knotted: A model for the structure and activation of Spatzle
19. Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila
20. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
21. Drosophila immunity: Two paths to NF-κB
22. The evolution and genetics of innate immunity
23. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
24. TIRAP: An adapter molecule in the Toll signaling pathway
25. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
26. The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila
27. Drosophila MyD88 is an adapter in the Toll signaling pathway
28. Drosophila MyD88 is required for the response to fungal and Gram- positive bacterial infections
29. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
30. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFκB
31. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
32. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
33. TAK1 is a ubiquitin-dependent kinase of MKK and IKK
34. Toll receptors in innate immunity
35. Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
36. NF-κB signaling pathways in mammalian and insect innate immunity
37. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses
38. The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
39. Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage
40. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
41. Signaling in plant-microbe interactions
42. Innate immunity in plants
43. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
44. CARD15 mutations in Blau syndrome
45. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
46. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
47. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
48. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways
49. The lipopolysaccharides of the phytopathogen Xanthomonas campestris pv. campestris induce an oxidative burst reaction in cell cultures of Nicotiana tabacum
50. FLS2: An LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis
51. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
52. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
53. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor 2
54. Discrimination of bacterial lipoproteins by Toll-like receptor 6
55. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
56. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
57. Recognition of double-stranded RNA and activation of NF-κB by Toll- like receptor 3
58. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the TLR4 gene
59. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
60. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
61. Mouse toll-like receptor 4MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
62. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
63. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
64. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
65. A Toll-like receptor recognizes bacterial DNA