CD28 and T cell co-stimulation

Reviews in Immunogenetics

Volumn 2, Issue 2, 2000, Pages 175-184

  Holdorf, A D ^a   Kanagawa, O ^a   Shaw, A S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anergy; CD28; Co stimulation; IL 2; T cell

Indexed keywords

CD28 ANTIGEN; CD47 ANTIGEN; CELL ANTIGEN; CELL MEMBRANE PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

CELL ENERGY; CELL PROLIFERATION; CELL STIMULATION; CORRELATION FUNCTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; REACTION ANALYSIS; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMAL; ANTIGENS, CD28; CELL SURVIVAL; HUMAN; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; NF-KAPPA B; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0033772368     PISSN: 13981714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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31. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation
32. The role of Tec protein-tyrosine kinase in T cell signaling
33. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase
34. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT
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41. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
42. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes
43. CD3- and CD28- dependent induction of PDE7 required for T cell activation
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51. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation
52. JNK is involved in signal integration during costimulation of T lymphocytes
53. Role of the CD28 receptor in T-cell activation
54. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
55. Molecular mechanisms of T lymphocyte activation: Convergence of T cell antigen receptor and IL-1 receptor-induced signaling at the level of IL-2 gene transcription
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58. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
59. The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65
60. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes
61. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites
62. Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element
63. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells
64. IkappaB kinases serve as a target of CD28 signaling
65. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
66. CD28 costimulation regulates long-term expression of the three genes (alpha, beta, gamma) encoding the high-affinity IL2 receptor
67. CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes
68. CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression
69. Immune responses in interleukin-2-deficient mice
70. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
71. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
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73. Mechanisms and consequences of activation of protein kinase B/Akt
74. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
75. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
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79. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling
80. Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation
81. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells
82. Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: Studies with a selective inhibitor, wortmannin
83. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation
84. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
85. T cell co-stimulatory molecules other than CD28