Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport

Journal of Clinical Investigation

Volumn 108, Issue 1, 2001, Pages 41-50

  Ozawa, K ^a   Kondo, T ^a   Hori, O ^a   Kitao, Y ^a   Stern, D M ^a   Eisenmenger, W ^a   Ogawa, S ^a   Ohshima, T ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; OXYGEN REGULATED PROTEIN 150; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR TRANSPORT; MACROPHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; WOUND HEALING;

ADENOVIRIDAE; ANIMALS; CELL HYPOXIA; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DIABETES COMPLICATIONS; DIABETES MELLITUS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHOKINES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOLECULAR CHAPERONES; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; NUCLEAR PROTEINS; OXYGEN; PROTEIN TRANSPORT; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; RNA, ANTISENSE; RNA, MESSENGER; SINGLE-BLIND METHOD; SKIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; WOUND HEALING;

EID: 0034946944     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200111772     Document Type: Article

References (45)

1. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
2. Cutaneous wound healing
3. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels
4. Antiangiogenic gene therapy in a rat glioma model using a dominant-negative vascular endothelial growth factor receptor 2
5. Role of vascular endothelial growth factor in the response to vessel injury
6. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
7. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
8. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
9. Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart
10. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
11. Induction characteristics of oxygen regulated protein
12. Hypoxia-reoxygenation mediated induction of interleukin-6 in cultured rat astrocytes and expression in ischemic gerbil brain: A paracrine mechanism enhancing neuron-survival
13. Purification and characterization of a novel stress protein, the 150kDa oxygen regulated protein (ORP150), from cultured rat astrocytes, and its expression in ischemic mouse brain
14. Cloning and expression of cDNA encoding the human 150 kDa oxygen regulated protein, ORP150
15. Marked, sustained expression of a novel 150kDa oxygen regulated stress protein, in severely ischemic mouse neurons
16. 150 kDa oxygen regulated protein (ORP150) is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxi and modified LDL
17. Expression of 150 kDa oxygen-regulated protein (ORP150), a new member of the HSP70 Family, in human breast cancers
18. Stress-associated endoplasmic reticulum protein 1 (SERP1)/ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation
19. Synthesis and release of interleukin-1 by reoxygenated human mononuclear phagocyte
20. Hypoxia modulates the barrier and coagulant Function of cultured bovine endothelium
21. Nitric oxide triggers enhanced induction of vascular endothelial growth Factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair
22. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death
23. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
24. Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation
25. Role of ERAB/L-3 hydroxyacyl-coenzyme A dehydrogenase type II activity in Aβ-induced cytotoxicity
26. Protein measurement with the Folin phenol reagent
27. PDGF and FGF stimulate wound healing in the genetically diabetic mouse
28. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
29. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues
30. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and β2 integrin activation
31. Impaired wound repair and delayed angiogenesis in aged mice
32. Selective regulation of cytokine induction by adenoviral gene transfer of IκBα into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-κB independent
33. Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor-α production in rheumatoid arthritis is NF-κB dependent
34. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing
35. Mammalian stress response: Induction of the glucose regulated protein family
36. Oxygen regulated 80 kDa protein and glucose regulated 78kDa protein are identical
37. Out of the ER: Outfitters, escorts and guides
38. Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF
39. Disulfide structure of the heparin binding domain in vascular endothelial growth factor: Characterization of posttranslational modifications in VEGF
40. The in vivo bioactivity of vascular endothelial growth factor/vascular permeability factor is independent of N-linked glycosylation
41. The 150 kDa oxygen regulated protein (ORP150) functions as a novel molecular chaperone in the protein transport of the MDCK cells
42. ORP150 protects against hypoxia/ischemia-induced neuronal death
43. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide
44. Expression of HSP70 in healing wounds of diabetic and nondiabetic mice
45. Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing