Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 44323-44330

  Vaux, Emma C ^a   Wood, S Morwenna ^a   Cockman, Matthew E ^a   Nicholls, Lynn G ^a   Yeates, Kay M ^a   Pugh, Christopher W ^a   Maxwell, Patrick H ^a   Ratcliffe, Peter J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELLS; CLONING; DEFECTS; DNA; MUTAGENESIS; TUMORS;

MUTAGENIZED CULTURES; OXYGEN-REGULATED PROCESSING;

BIOCHEMISTRY;

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MEMBRANE ANTIGEN; UBIQUITIN; DNA; DNA BINDING PROTEIN; LIGASE; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL MUTANT; CHO CELL; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; GENETIC SCREENING; GENETIC TRANSFECTION; HYPOXIA; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU GENE; ANIMAL; CELL CLONE; CELL FUSION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; HAMSTER; HYDROLYSIS; MOLECULAR GENETICS; MOUSE; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; VON HIPPEL LINDAU DISEASE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; EUKARYOTA;

ANIMALS; BASE SEQUENCE; CELL FUSION; CHO CELLS; CLONE CELLS; CRICETINAE; DNA; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; GENETIC COMPLEMENTATION TEST; HIPPEL-LINDAU DISEASE; HYDROLYSIS; LIGASES; MICE; MOLECULAR SEQUENCE DATA; MUTATION; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0035941195     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104678200     Document Type: Article

References (44)

1. Semenza, G. (2000) Genes Dev. 14, 1983-1991
2. Wenger, R. H. (2000) J. Exp. Biol. 203, 1253-1263
3. Ebert, B. L., and Bunn, H. F. (1999) Blood 94, 1864-1877
4. Wang, G. L., Jiang, B.-H., Rue, E. A., and Semenza, G. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5510-5514
5. Huang, L. E., Arany, Z., Livingston, D. M., and Bunn, H. F. (1996) J. Biol. Chem. 271, 32253-32259
6. Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J. M., and Ratcliffe, P. J. (1997) J. Biol. Chem. 272, 11205-11214
7. Salceda, S., and Caro, J. (1997) J. Biol. Chem. 272, 22642-22647
8. Huang, L. E., Gu, J., Schau, M., and Bunn, H. F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7987-7992
9. Kallio, P. J., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H., and Poellinger, L. (1998) EMBO J. 17, 6573-6586
10. Bhattacharya, S., Michels, C. L., Leung, M.-K., Arany, Z. P., Kung, A. L., and Livingston, D. M. (1999) Genes Dev. 13, 64-75
11. Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) Nature 399, 271-275
12. Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (2000) J. Biol. Chem. 275, 25733-25741
13. Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V., and Kaelin, W. G. (2000) Nat. Cell Biol 2,423-427
14. Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R. C., and Conaway, J. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10430-10435
15. Tanimoto, K., Makino, Y., Pereira, T., and Poellinger, L. (2000) EMBO J. 19, 4298-4309
16. Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Avon, K., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Science 292, 468-472
17. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G., Jr. (2001) Science 292, 464-468
18. Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F.-M., Lubensky, I., Duan, D. R., Florence, C., Pozzatti, R., Walther, M. M., Bander, N. H., Grossman, H. B., Brauch, H., Pomer, S., Brooks, J. D., Isaacs, W. B., Lerman, M. I., Zbar, B., and Linehan, W. M. (1994) Nat. Genet. 7, 85-90
19. Iliopoulos, O., Levy, A. P., Jiang, C., Kaelin, W. G., Jr., and Goldberg, M. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10595-10599
20. Gnarra, J. R., Zhou, S., Merrill, M. J., Wagner, J. R., Krumm, A., Papavassiliou, E., Oldfield, E. H., Klausner, R. D., and Linehan, W. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10589-10594
21. Wykoff, C. C., Pugh, C. W., Maxwell, P. H., Harris, A. L., and Ratcliffe, P. J. (2000) Oncogene 19, 6297-6305
22. Zelzer, E., Levy, Y., Kahana, C., Shilo, B.-Z., Rubinstein, M., and Cohen, B. (1998) EMBO J. 17, 5085-5094
23. Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., and Bedi, A. (2000) Genes Dev. 14, 34-44
24. Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., Stokoe, D., and Giaccia, A. J. (2000) Genes Dev. 14, 391-396
25. Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M.-M., Simons, J. W., and Semenza, G. L. (2000) Cancer Res. 60, 1541-1545
26. Richard, D. E., Berra, E., Gothie, E., Roux, D., and Pouysségur, J. (1999) J. Biol. Chem. 274, 32631-32637
27. Conrad, P. W., Freeman, T. L., Beitner-Johnson, D., and Millhorn, D. E. (1999) J. Biol. Chem. 274, 33709-33713
28. Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H., and Ratcliffe, P. J. (1998) J. Biol. Chem. 273, 8360-8368
29. O'Neill, J. P., Fuscoe, J. C., and Hsie, A. W. (1978) Cancer Res. 38, 506-509
30. O'Rourke, J. F., Tian, Y.-M., Ratcliffe, P. J., and Pugh, C. W. (1999) J. Biol. Chem. 274, 2060-2071
31. Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2423-2427
32. Vaux, E. C., Metzen, E., Yeates, K. M., and Ratcliffe, P. J. (2001) Blood 98, 296-302
33. Hasegawa, K., Anraku, Y., Kasahara, M., Akamatsu, Y., and Nishijima, M. (1990) Biochim. Biophys. Acta 1051, 221-229
34. Wiesener, M. S., Turley, H., Allen, W. E., William, C., Eckardt, K.-U., Talks, K. L., Wood, S. M., Gatter, K. C., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (1998) Blood 92, 2260-2268
35. Woodward, E. R., Hurst, L. D., Clifford, S. C., Affara, N. A., and Maher, E. R. (2000) Genomics 65, 253-265
36. McKendry, R., John, J., Flavell, D., Muller, M., Kerr, I. M., and G. R., S. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11455-11459
37. Berra, E., Richard, D.E., Gothie, E., and Pouyssegur, J. (2001) FEBS Lett. 491, 85-90
38. Taft, S. A., Liber, H. L., and Skopek, T. R. (1994) Environ. Mol. Mutagen 23, 96-100
39. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., and Sfez, S., et al. (1995) Science 268, 1700-1701
40. Iliopoulos, O., Kibel, A., Gray, S., and Kaelin, W. G., Jr. (1995) Nature Medicine 1, 822-826
41. Ohh, M., Yauch, R. L., Lonergan, K. M., Whaley, J. M., Stemmer-Rachamimov, A. O., Louis, D. N., Gavin, B. J., Kley, N., Kaelin, W. G., Jr., and Iliopoulos, O. (1998) Mol. Cell 1, 959-968
42. Pause, A., Lee, S., Lonergan, K. M., and Klausner, R. D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 993-998
43. Gorospe, M., Egan, J. M., Zbar, B., Lerman, M., Geil, L., Kurzin, I., and Holbrook, N. J. (1999) Mol. Cell. Biol. 19, 1289-1300
44. Schoenfeld, A. R., Parris, T., Eisenberger, A., Davidowitz, E. J., Leon, M. D., Talasazan, F., Devarajan, P., and Burk, R. D. (2000) Oncogene 19, 5851-5858