Molecular heterogeneity of diffuse large B-cell lymphoma: Implications for disease management and prognosis

Hematology

Volumn 7, Issue 4, 2002, Pages 239-252

  Rossi, Davide ^a   Gaidano, Gianluca ^a  

^a Hematology Unit   (Italy)

Author keywords

Diffuse large B cell lymphoma; Immune function; Molecular pathogenesis; Non Hodgkin lymphoma

Indexed keywords

MYC PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL 6; PROTEIN BCL 8; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; B CELL LYMPHOMA; B LYMPHOCYTE ACTIVATION; CANCER CLASSIFICATION; CLINICAL FEATURE; CONTROLLED STUDY; DNA MICROARRAY; GENE ACTIVATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GERMINAL CENTER; HEMATOPOIETIC TISSUE; HUMAN; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNOPATHOGENESIS; LARGE CELL LYMPHOMA; LYMPHOID TISSUE; NONHODGKIN LYMPHOMA; ONCOGENE C MYC; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE; REVIEW; TREATMENT OUTCOME; WORLD HEALTH ORGANIZATION;

EID: 0036440942     PISSN: 10245332     EISSN: None     Source Type: Journal    
DOI: 10.1080/1024533021000024058     Document Type: Review

References (132)

1. Harris, N.L., Jaffe, E.S., Stein, H., Banks, P.M., Chan, J.C.K., Cleary, M.L., Delsol, G., De Wolf-Peeters, C., Falini, B., Gatter, Kc., Groan, T.M., Isaacson, P.G., Knowles, D.M., Mason, D.Y, Müller-Hermelink, H.K., Pileri, S.A., Piris, M.A., Ralfkiaer, E. and Warnke, R.A. (1994) "A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma. Study Group", Blood 84, 1361-1392.
2. Jaffe, E.S., Harris, N.L., Stein, H. and Vardiman, J.W. (2001) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues (IARC Press, Lyon).
3. Dalla Favera, R. and Gaidano, G. (1998) "The biology of high grade non-Hodgkin lymphomas", In.: Cannellos, G.P., Lister, T.A. and Sklar, J.L., eds, The Lymphomas (W.B. Saunders Company, Philadelphia), pp. 353-367.
4. Dalla Favera, R. and Gaidano, G. (2000) "Pathobiology of non-Hodgkin lymphomas", In: Hoffman, R., Benz, E.J., Shattil, S.J., Furie, B., Choen, H.J., Silberstein, L.E. and McGlave, P., eds, Hematology. Basic Principle and Practice, 3rd Ed. (Churchill Linvingstone, Philadelphia), pp. 1213-1229.
5. Dalla Favera, R. and Gaidano, G. (2001) "Molecular biology of Lymphomas", In: De Vita, V.T., Hellman, S. and Rosenberg, S.A., eds, Cancer. Principles and Practice of Oncology, 6th Ed. (Lippincott Williams, Philadelphia), pp. 2215-2235.
6. Offit, K., Wong, G., Filippa, D.A., Tao, Y. and Chaganti, R.S. (1991) "Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: clinical correlations", Blood 77, 1508-1515.
7. Gamberi, B., Gaidano, G., Parsa, N., Carbone, A., Roncella, S., Knowles, D.M., Louie, D.C., Shibata, D., Chaganti, R.S. and Dalla-Favera, R. (1997) "Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas", Blood 89, 975-979.
8. Mülller-Hermelink, H.K. and Greiner, A. (1998) "Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells", Am. J. Pathol. 153, 1341-1346.
9. Shen, H.M., Peters, A., Baron, B., Zhu, X. and Storb, U. (1998) "Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes", Science 280, 1750-1752.
10. Pasqualucci, L., Migliazza, A., Fracchiolla, N., William, C., Neri, A., Baldini, L., Chaganti, R.S., Klein, U., Küppers, R., Rajewsky, K. and Dalla-Favera, R. (1998) "BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci", Proc. Natl. Acad. Sci. USA 95, 11816-11821.
11. Küppers, R., Klein, U., Hansmann, M.L. and Rajewsky, K. (1999) "Cellular origin of human B-cell lymphomas", N. Engl. J. Med. 341, 1520-1529.
12. Peng, H.Z., Du, M.Q., Koulis, A., Aiello, A., Dogan, A., Pan, L.X. and Isaacson, P.G. (1999) "Nonimmunoglobulin gene hypermutation in germinal center B cells", Blood 93, 2167-2172.
13. Gaidano, G. and Carbone, A. (2000) "MUM1: a step ahead toward the understanding of lymphoma histogenesis", Leukemia 14, 563-566.
14. Harris, N.L., Stein, H., Coupland, S.E., Hummel, M., Dalla Favera, R., Pasqualucci, L. and Chan, W.C. (2001) "New approaches to lymphoma diagnosis", Hematology (Am. Soc. Hematol. Educ. Program), 194-220.
15. Cattoretti, G., Chang, C.C., Cechova, K., Zhang, J., Ye, B.H., Falini, B., Louie, D.C., Offit, K., Chaganti, R.S. and Dalla-Favera, R. (1995) "BCL-6 protein is expressed in germinal center B-cells", Blood 86, 45-53.
16. Sebestyen, A., Berczi, L., Mihalik, R., Paku, S., Matolcsy, A. and Kopper, L. (1999) "Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas", Br. J. Haematol. 104, 412-419.
17. Falini, B., Fizzotti, M., Pucciarini, A., Bigerna, B., Marafioti, T., Gambacorta, M., Pacini, R., Alunni, C., Natali-Tanci, L., Ugolini, B., Sebastiani, C., Cattoretti, G., Pileri, S., Dalla-Favera, R. and Stein, H. (2000) "A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells", Blood 95, 2084-2092.
18. Falini, B. and Mason, D.Y. (2002) "Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry", Blood 99, 409-426.
19. Hsu, F.J. and Levy, R. (1995) "Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma", Blood 86, 3072-3082.
20. Migliazza, A., Martinotti, S., Chen, W., Fusco, C., Ye, B.H., Knowles, D.M., Offit, K., Chaganti, R.S. and Dalla-Favera, R. (1995) "Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma", Proc. Natl. Acad. Sci. USA 92, 12520-12524.
21. Küppers, R., Rajewsky, K. and Hansmann, M.L. (1997) "Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression", Eur. J. Immunol. 27, 1398-1405.
22. Taniguchi, M., Oka, K., Hiasa, A., Yamaguchi, M., Ohno, T., Kita, K. and Shiku, H. (1998) "De novo CD5 + diffuse large B-cell lymphomas express VH genes with somatic mutation", Blood 91, 1145-1151.
23. Ottensmeier, C.H., Thompsett, A.R., Zhu, D., Wilkins, B.S., Sweetenham, J.W. and Stevenson, F.K. (1998) "Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression", Blood 91, 4292-4299.
24. Harada, S., Suzuki, R., Uehira, K., Yatabe, Y., Kagami, Y., Ogura, M., Suzuki, H., Oyama, A., Kodera, Y., Ueda, R., Morishima, Y., Nakamura, S. and Seto, M. (1999) "Molecular and immunological dissection of diffuse large B cell lymphoma: CD5 +, and CD5 - with CD10 + groups may constitute clinically relevant subtypes", Leukemia 13, 1441-1447.
25. Capello, D., Vitolo, U., Pasqualucci, L., Quattrone, S., Migliaretti, G., Fassone, L., Ariatti, C., Vivenza, D., Gloghini, A., Pastore, C., Lanza, C., Nomdedeu, J., Botto, B., Freilone, R., Buonaiuto, D., Zagonel, V., Gallo, E., Palestro, G., Saglio, G., Dalla-Favera, R., Carbone, A. and Gaidano, G. (2000) "Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia", Blood 95, 651-659.
26. Lossos, I.S., Okada, C.Y., Tibshirani, R., Warnke, R., Vose, J.M., Greiner, T.C. and Levy, R. (2000) "Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas", Blood 95, 1797-1803.
27. Ottensmeier, C.H. and Stevenson, F.K. (2000) "Isotype switch variants reveal clonally related subpopulations in diffuse large B-cell lymphoma", Blood 96, 2550-2556.
28. Nakamura, N., Kuze, T., Hashimoto, Y., Hara, Y., Hoshi, S., Sasaki, Y., Shirakawa, A., Sato, M. and Abe, M. (2001) "Analysis of the immunoglobulin heavy chain gene variable region of CD5-positive and -negative diffuse large B cell lymphoma", Leukemia 15, 452-457.
29. Gaidano, G., Carbone, A., Pastore, C., Capello, D., Migliazza, A., Gloghini, A., Roncella, S., Ferrarini, M., Saglio, G. and Dalla-Favera, R. (1997) "Frequent mutation of the 5′ noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas", Blood 89, 3755-3762.
30. Gaidano, G., Carbone, A. and Dalla-Favera, R. (1998) "Pathogenesis of AIDS-related lymphomas: molecular and histogenetic heterogeneity", Am. J. Pathol. 152, 623-630.
31. Gaidano, G., Capello, D., Gloghini, A., Pastore, C., Migliazza, A., Quattrone, S., Savinelli, F., Buonaiuto, D., Cilia, A.M., Perin, T., Pasqualucci, L., Canzonieri, V, Saglio, G., Dalla-Favera, R. and Carbone, A. (1998) "BCL-6 in AIDS-related lymphomas: pathogenetic and histogenetic implications", Leuk. Lymphoma 31, 39-46.
32. Gaidano, G., Capello, D. and Carbone, A. (2000) "The molecular basis of acquired immunodeficiency syndrome-related lymphomagenesis", Semin. Oncol. 27, 431-441.
33. Carbone, A., Gloghini, A., Capello, D. and Gaidano, G. (2001) "Genetic pathways and histogenetic models of AIDS-related lymphomas", Eur. J. Cancer 37, 1270-1275.
34. Carbone, A., Gaidano, G., Gloghini, A., Pastore, C., Saglio, G., Tirelli, U., Dalla-Favera, R. and Falini, B. (1997) "BCL-6 protein expression in AIDS-related non-Hodgkin's lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression", Am. J. Pathol. 150, 155-165.
35. Carbone, A., Gaidano, G., Gloghini, A., Larocca, L.M., Capello, D., Canzonieri, V, Antinori, A., Tirelli, U., Falini, B. and Dalla-Favera, R. (1998) "Differential expression of BCL-6, CD138/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas", Blood 91, 747-755.
36. Carbone, A., Gloghini, A., Larocca, L.M., Capello, D., Pierconti, F., Canzonieri, V., Tirelli, U., Dalla-Favera, R. and Gaidano, G. (2001) "Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas", Blood 97, 744-751.
37. Cesarman, E., Chadburn, A., Liu, Y.F., Migliazza, A., Dalla-Favera, R. and Knowles, D.M. (1998) "BCL-6 gene mutations in posttransplantation lymphoproliferative disorders predict response to therapy and clinical outcome", Blood 92, 2294-2302.
38. Capello, D., Vivenza, D., Muti, G., Rossi, D., Berra, E., Franceschetti, S., Oreste, P., Viglio, A., Morra, E., Paulli, M. and Gaidano, G. (2001) "Molecular histogenesis of post-transplant lymphoproliferative disorders", Blood 98, 805a.
39. Ariatti, C., Vivenza, D., Capello, D., Migliazza, A., Parvis, G., Fassone, L., Buonaiuto, D., Savinelli, F., Rossi, D., Saglio, G. and Gaidano, G. (2000) "Common-variable immunodeficiency-related lymphomas associate with mutations and rearrangements of BCL-6: pathogenetic and histogenetic implications", Hum. Pathol. 31, 871-873.
40. Ariatti, C., Rossi, D., Vivenza, D., Berra, E., Benevolo, G., Fontana, M. and Conconi, A. (2001) "Molecular characterization of common variable immunodeficiency-related lymphomas", Ann. Ital. Med. Int. 16, 163-169.
41. Vanasse, G.J., Concannon, P. and Willerford, D.M. (1999) "Regulated genomic instability and neoplasia in the lymphoid lineage", Blood 94, 3997-4010.
42. Willis, T.G. and Dyer, M.J. (2000) "The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies", Blood 96, 808-822.
43. Offit, K., Jhanwar, S., Ebrahim, S., Filippa, D., Clarkson, B.D. and Chaganti, R.S. (1989) "t(3;22)(q27;q11), a novel translocation associated with diffuse non-Hodgkin lymphoma", Blood 74, 1876-1879.
44. Bastard, C., Tilly, H., Lenorman, B., Bigorgne, C., Boulet, D., Kunlin, A., Monconduit, M. and Piguet, H. (1992) "Translocations involving band 3q27 and Ig gene regions in non-Hodgkin lymphomas", Blood 79, 2527-2531.
45. Baron, B.W., Nucifora, G., McCabe, N., Espinosa, 3rd, R., Le Beau, M.M. and McKeithan, T.W. (1993) "Identification of the gene associated with the recurring chromosomal translocations; t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas", Proc. Natl. Acad. Sci. USA 90, 5262-5266.
46. Kerckaert, J.P., Deweindt, C., Tilly, H., Quief, S., Lecocq, G. and Bastard, C. (1993) "LAZ3, a novel zinc finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphoma", Nat. Genet. 5, 66-70.
47. Ye, B.H., Lista, F., Lo Coco, F., Knowles, D.M., Offit, K., Chaganti, R.S. and Dalla-Favera, R. (1993) "Alterations of BCL-6, a novel zinc finger gene, in diffuse large cell lymphoma", Science 262, 747-750.
48. Ye, B.H., Rao, P.H., Chaganti, R.S. and Dalla-Favera, R. (1993) "Cloning of BCL-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma", Cancer. Res. 53, 2732-2735.
49. Miki, T., Kawamata, N., Arai, A., Ohashi, K., Nakamura, Y., Kato, A., Hirosawa, S. and Aoki, N. (1994) "Molecular cloning of the breakpont for 3q27 translocation in B-cell lymphomas and leukemias", Blood 83, 217-222.
50. Bardwell, V.J. and Treisman, R. (1994) "The POZ domain: a conserved protein-protein interaction motif", Genes. Dev. 8, 1664-1677.
51. Chang, C.C., Ye, B.H., Chaganti, R.S. and Dalla-Favera, R. (1996) "BCL-6, a POZ/zinc finger protein, is a sequence specific transcriptional repressor", Proc. Natl. Acad. Sci. USA 93, 6947-6952.
52. Allman, D., Jain, A., Dent, A., Maile, R.R., Selvaggi, T., Kehry, M.R. and Staudt, L.M. (1996) "BCL-6 expression during B-cell activation", Blood 87, 5257-5268.
53. Dalla-Favera, R., Ye, B.H., Cattoretti, G., Lo Coco, F., Chang, C.C., Zhang, J., Migliazza, A., Cechova, K., Niu, H., Chaganti, S., Chen, W., Louie, D.C., Offit, K. and Chaganti, R.S. (1996) "BCL-6 in diffuse large cell lymphomas", Important Adv. Oncol., 139-148.
54. Dent, A.L., Shaffer, A.L., Yu, X., Allman, D. and Staudt, L.M. (1997) "Control of inflammation cytokine expression and germinal center formation by BCL-6", Science 276, 589-592.
55. Ye, B.H., Cattoretti, G., Shen, Q., Zhang, J., Hawe, N., de Waard, R., Leung, C., Nouri-Shirazi, M., Orazi, A., Chaganti, R.S., Rothman, P., Stall, A.M., Pandolfi, P.P. and Dalla-Favera, R. (1997) "The BCL-6 proto-oncogene controls germinal centre formation and TH2 type inflammation", Nat. Genet. 16, 161-170.
56. Ye, B.H., Chaganti, S., Chang, C.C., Niu, H., Corradini, P., Chaganti, R.S. and Dalla-Favera, R. (1995) "Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma", EMBO J. 14, 6209-6217.
57. Chen, W., Iida, S., Louie, D.C., Dalla-Favera, R. and Chaganti, R.S. (1998) "Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation", Blood 91, 603-607.
58. Bastard, C., Deweindt, C., Kerckaert, J.P., Lenormand, B., Rossi, A., Pezzella, F., Fruchart, C., Duval, C., Monconduit, M. and Tilly, H. (1994) "LAZ3 rearrangements in non-Hodgkin lymphoma: correlation with histology, immunophenotype, karyotype and clinical outcome in 217 patients", Blood 83, 2423-2427.
59. Lo Coco, F., Ye, B.H., Lista, F., Corradini, P., Offit, K., Knowles, D.M., Chaganti, R.S. and Dalla-Favera, R. (1994) "Rearrangenents of BCL-6 gene in diffuse large cell non-Hodgkin lymphoma", Blood 83, 1757-1759.
60. Butler, M.P., Iida, S., Capello, D., Rossi, D., Rao, P.H., Nallasivam, P., Louie, D.C., Chaganti, S., Au, T., Gascoyne, R.D., Gaidano, G., Chaganti, R.S.K. and Dalla-Favera, R. (2002) "Alternative translocation breakpoint cluster region 5′ to BCL-6 in B-cell non-Hodgkin Lymphoma", Cancer Res. 62, 4089-4094.
61. Offit, K., Lo Coco, F., Louie, D.C., Parsa, N.Z., Leung, D., Portlock, C., Ye, B.H., Lista, F., Filippa, D.A., Rosenbaum, A., Ladany, M., Jhanwar, S., Dalla-Favera, R. and Chaganti, R.S. (1994) "Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma", N. Engl. J. Med. 331, 74-80.
62. Otsuki, T., Yano, T., Clark, H.M., Bastard, C., Kerckaert, J.P., Jaffe, E.S. and Raffeld, M. (1995) "Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas: results of rearrangement and gene expression studies and a mutational analysis of coding region sequences", Blood 85, 2877-2884.
63. Pescarmona, E., De Sanctis, V., Pistilli, A., Pacchiarotti, A., Martelli, M., Guglielmi, C., Mandelli, F., Baroni, C.D. and Lo Coco, F. (1997) "Pathogenetic and clinical implications of Bcl-6 and Bcl-2 gene configuration in nodal diffuse large B-cell lymphomas", J. Pathol. 183, 281-286.
64. Kramer, M.H., Hermans, J., Wijburg, E., Philippo, K., Geelen, E., van Krieken, J.H., de Jong, D., Maartense, E., Schuuring, E. and Kluin, P.M. (1998) "Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma", Blood 92, 3152-3162.
65. Vitolo, U., Gaidano, G., Botto, B., Volpe, G., Audisio, E., Bertini, M., Calvi, R., Freilone, R., Novero, D., Orsucci, L., Pastore, C., Capello, D., Parvis, G., Sacco, C., Zagonel, V., Carbone, A., Mazza, U., Palestro, G., Saglio, G. and Resegotti, L. (1998) "Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: clinical relevance in 71 patients", Ann. Oncol. 9, 55-61.
66. Kawasaki, C., Ohshim, K., Suzumiya, J., Kanda, M., Tsuchiya, T., Tamura, K. and Kikuchi, M. (2001) "Rearrangements of bcl-1, bcl-2, bcl-6, and c-myc in diffuse large B-cell lymphomas", Leuk. Lymphoma 42, 1099-1106.
67. Jerkeman, M., Aman, P., Cavallin-Stahl, E., Torlakovic, E., Akerman, M., Mitelman, F. and Fioretos, T. (2002) "Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma-a Nordic Lymphoma Group study", Int. J. Oncol. 20, 161-165.
68. Capello, D., Carbone, A., Pastore, C., Gloghini, A., Saglio, G. and Gaidano, G. (1997) "Point mutations of the BCL-6 gene in Burkitt's lymphoma", Br. J. Haematol. 99, 168-170.
69. Vitolo, U., Botto, B., Capello, D., Vivenza, D., Zagonel, V., Gloghini, A., Novero, D., Parvis, G., Calvi, R., Ariatti, C., Milan, I., Bestini, M., Boccomini, C., Freilone, R., Pregno, P., Orsucci, L., Palestro, G., Saglio, G., Carbone, A., Gallo, E. and Gaidano, G. (2002) "Point mutations of the BCL-6 gene: clinical and prognostic correlation in B-diffuse large cell lymphoma", Leukemia 16, 268-275.
70. Alizadeh, A.A., Eisen, M.B., Davis, R.E., Ma, C., Lossos, I.S., Rosenwald, A., Boldrick, J.C., Sabet, H., Tran, T., Yu, X., Powell, J.I., Yang, L., Marti, G.E., Moore, T., Hudson, Jr, J., Lu, L., Lewis, D.B., Tibshirani, R., Sherlock, G., Chan, W.C., Greiner, T.C., Weisenburger, D.D., Armitage, J.O., Warnke, R. and Staudt, L.M. (2000) "Distinct types of diffuse large B cell lymphoma identified by gene expression profiling", Nature 403, 503-511.
71. Rosenwald, A., Wright, G., Chan, W.C., Connors, J.M., Campo, E., Fisher, R.I., Gascoyne, R.D., Muller-Hermelink, H.K., Smeland, E.B., Giltnane, J.M., Hurt, E.M., Zhao, H., Averett, L., Yang, L., Wilson, W.H., Jaffe, E.S., Simon, R., Klausner, R.D., Powell, J., Duffey, P.L., Longo, D.L., Greiner, T.C., Weisenburger, D.D., Sanger, W.G., Dave, B.J., Lynch, J.C., Vose, J., Armitage, J.O., Montserrat, E., Lopez-Guillermo, A., Grogan, T.M., Miller, T.P., LeBlanc, M., Ott, G., Kvaloy, S., Delabie, J., Holte, H., Krajci, P., Stokke, T. and Staudt, L.M. (2002) Lymphoma/Leukemia Molecular Profiling Project "The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma", N. Engl. J. Med. 346, 1937-1947.
72. Bakhshi, A., Jensen, J.P., Goldman, P., Wright, J.J., McBride, O.W., Epstein, A.L. and Korsmeyer, S.J. (1985) "Cloning the chromosomal breakpoint of t(14;18) of human lymphomas: clustering around JH on chromosome 14 and near a transcriptiona unit on 18", Cell 41, 889-906.
73. Tsujimoto, Y., Finger, L.R., Yunis, J., Nowell, P.C. and Croce, C.M. (1984) "Cloning of the chromosome breakpoints of neoplastic B-cells with t(14;18) chromosomal translocation", Science 226, 1097-1099.
74. Cleary, M.L. and Sklar, J. (1985) "Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18", Proc. Natl. Acad. Sci. USA 82, 7439-7443.
75. Cleary, M.L., Smith, S.D. and Sklar, J. (1986) "Cloning and structural analysis of cDNAs for BCL-2 and a hybrid BCL-2/immunoglobulin transcript resulting from the t(14;18) translocation", Cell 47, 19-28.
76. Cleary, M.L., Galili, N. and Sklar, J. (1986) "Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas", J. Exp. Med. 164, 315-320.
77. Volpe, G., Vitolo, U., Carbone, A., Pastore, C., Bertini, M., Botto, B., Audisio, E., Freilone, R., Novero, D., Cappia, S., De Giuli, P., Mazza, U., Resegotti, L., Palestro, G., Saglio, G. and Gaidano, G. (1996) "Molecular heterogeneity of B-lineage diffuse large cell lymphoma", Gene Chromosom. Cancer 16, 21-30.
78. Lo Coco, F., Gaidano, G., Louie, D.C., Offit, K., Chaganti, R.S. and Dalla-Favera, R. (1993) "p53 mutations are associated with histologic transformation of follicular lymphomas", Blood 82, 2289-22895.
79. Rao, P.H., Houldsworth, J., Dyomina, K., Parsa, N.Z., Cigudosa, J.C., Louie, D.C., Popplewell, L., Offit, K., Jhanwar, S.C. and Chaganti, R.S. (1998) "Chromosomal and gene amplification in diffuse large B-cell lymphoma", Blood 92, 234-240.
80. Monni, O., Joensuu, H., Franssila, K., Klefstrom, J., Alitalo, K. and Knuutila, S. (1997) "BCL-2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma", Blood 90, 1168-1174.
81. Chao, D.T. and Korsmeyer, S.J. (1998) "BCL-2 family: regulators of cell death", Annu. Rev. Immunol. 16, 395-419.
82. Gross, A., McDonnell, J.M. and Korsmeyer, S.J. (1999) "BCL-2 family members and the mitochondria in apoptosis", Genes Dev. 13, 1899-1911.
83. Jacobson, J.O., Wilkes, B.M., Kwaiatkowski, D.J., Medeiros, L.J., Aisenberg, A.C. and Harris, N.L. (1993) "Bcl-2 rearrangements in de novo diffuse large cell lymphoma. Association with distinctive clinical features", Cancer 72, 231-236.
84. Tang, S.C., Visser, L., Hepperle, B., Hanson, J. and Poppema, S. (1994) "Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases", J. Clin. Oncol. 12, 149-154.
85. Hill, M.E., MacLennan, K.A., Cunningham, D.C., Vaughan Hudson, B., Burke, M., Clarke, P., Di Stefano, F., Anderson, L., Vaughan Hudson, G., Mason, D., Selby, P. and Linch, D.C. (1996) "Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study", Blood 88, 1046-1051.
86. Gascoyne, R.D., Adomat, S.A., Krajewski, S., Krajewska, M., Horsman, D.E., Tolcher, A.W., O'Reilly, S.E., Hoskins, P., Coldman, A.J., Reed, J.C. and Connors, J.M. (1997) "Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma", Blood 90, 244-251.
87. Houldsworth, J., Mathew, S., Rao, P.H., Dyomina, K., Louie, D.C., Parsa, N., Offit, K. and Chaganti, R.S. (1996) "REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma", Blood 87, 25-29.
88. Lu, D., Thompson, J.D., Gorski, G.K., Rice, N.R., Mayer, M.G. and Yunis, J.J. (1991) "Alterations at the rel locus in human lymphoma", Oncogene 6, 1235-1241.
89. Kralova, J., Schatzle, J.D., Bargmann, W. and Bose, Jr, H.R. (1994) "Transformation of avian fibroblasts overexpressing the c-REL proto-oncogene and a variant of c-REL lacking 40 c-terminal aminoacids", J. Virol. 68, 2073-2083,
90. Dyomin, V.G., Rao, P.H., Dalla-Favera, R. and Chaganti, R.S. (1997) "BCL-8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large cell lymphoma", Proc. Natl. Acad. Sci. USA 94, 5728-5732.
91. Ladanyi, M., Offit, K., Jhanwar, S.C., Filippa, D.A. and Chaganti, R.S. (1991) "MYC rearrangement and translocations involving band 8q24 in diffuse large cell lymphoma", Blood 77, 1057-1063.
92. Akasaka, T., Akasaka, H., Ueda, C., Yonetani, N., Maesako, Y., Shimizu, A., Yamabe, H., Fukuhara, S., Uchiyama, T. and Ohno, H. (2000) "Molecular and clinical features of non-Burkitt's diffuse large cell lymphoma of B-cell type associated with the c-MYC immunoglobulin heavy chain fusion gene", J. Clin. Oncol. 18, 510-518.
93. Raghoebier, S., Kramer, M.H., van Krieken, J.H., de Jong, D., Limpens, J., Kluin-Nelemans, J.C., van Ommen, G.J. and Kluin, P.M. (1991) "Essential differencies in oncogene involvement between primary nodal and extranodal large cell lymphoma", Blood 78, 2680-2685.
94. Yano, T., Jaffe, E.S., Longo, D.L. and Raffeld, M. (1992) "MYC rearrangements in histologically progressed follicular lymphomas", Blood 80, 758-767.
95. Dyomin, V.G., Palanisamy, N., Lloyd, K.O., Dyomina, K., Jhanwar, S.C., Houldsworth, J. and Chaganti, R.S. (2000) "MUC-1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32) translocation and is rearranged and amplified in B-cell lymphoma subsets", Blood 95, 2666-2671.
96. Gilles, F., Goy, A., Remache, Y., Shue, P. and Zelenetz, A.D. (2000) "MUC-1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma", Blood 95, 2930-2936.
97. Wesseling, J., van der Valk, S.W., Vos, H.L., Sonnenberg, A. and Hilkens, J. (1995) "Episialine (MUC-1) overexpression inhibits integrin mediated cell adhesion to extracellular matrix components", J. Cell. Biol. 129, 255-265.
98. Agrawal, B., Krantz, M.J., Reddish, M.A. and Longenecker, B.M. (1998) "Cancer associated MUC-1 mucin inhibits human T cell proliferation, which is reversible by IL2", Nat. Med. 4, 43-49.
99. Baruch, A., Hartmann, M., Yoeli, M., Adereth, Y, Greenstein, S., Stadler, Y., Skornik, Y., Zaretsky, J., Smorodinsky, N.I., Keydar, I. and Wreschner, D.H. (1999) "The breast cancer associated MUC-1 gene generates both a receptor and his cognate binding protein", Cancer. Res. 59, 1552-1561.
100. Kirsch, D.G. and Kastan, M.B. (1998) "Tumor-suppressor p53: implications for tumor development and prognosis", J. Clin. Oncol. 16, 3158-3168.
101. Ichikawa, A., Kinoshita, T., Watanabe, T., Kato, H., Nagai, H., Tsushita, K., Saito, H. and Hotta, T. (1997) "Mutations of the p53 gene as a prognostic factor in aggressive B-cell lymphoma", N. Engl. J. Med. 337, 529-534.
102. Koduru, P.R., Raju, K., Vadmal, V., Menezes, G., Shah, S., Susin, M., Kolitz, J. and Broome, J.D. (1997) "Correlation between mutation in P53, p53 expression, cytogenetics, histologic type, and survival in patients with B-cell non-Hodgkin's lymphoma", Blood 90, 4078-4091.
103. INK4a gene inactivation by deletions, mutations and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin lymphomas", Blood 91, 2977-2984.
104. Sherr, C.J. (2001) "The INK4a/ARF network in tumour suppression", Nat. Rev. Mol. Cell Biol. 2, 731-737.
105. Serrano, M., Lee, H., Chin, L., Cordon-Cardo, C., Beach, D. and DePinho, R.A. (1996) "Role of the INK4a locus in tumor suppression and cell mortality", Cell 85, 27-37.
106. Singal, R. and Ginder, G.D. (1999) "DNA methylation", Blood 93, 4059-4070.
107. Pegg, A.E. (2000) "Repair of O(6)-alkylguanine by alkyltransferases", Mutat. Res. 462, 83-100.
108. Esteller, M., Gaidano, G., Goodman, S.N., Zagonel, V., Capello, D., Botto, B., Rossi, D., Gloghini, A., Vitolo, U., Carbone, A., Baylin, S.B. and Herman, J.G. (2002) "Hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma", J. Natl. Cancer Inst. 94, 26-32.
109. Esteller, M., Toyota, M., Sanchez-Cespedes, M., Capella, G., Peinado, M.A., Watkins, D.N., Issa, J.P., Sidransky, D., Baylin, S.B. and Herman, J.G. (2000) "Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis", Cancer Res. 60, 2368-2371.
110. Sakumi, K., Shiraishi, A., Shimizu, S., Tsuzuki, T., Ishikawa, T. and Sekiguchi, M. (1997) "Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice", Cancer Res. 57, 2415-2418.
111. Mattern, J., Eichhorn, U., Kaina, B. and Volm, M. (1998) "O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts", Int. J. Cancer 77, 919-922.
112. Cai, Y., Wu, M.H., Ludeman, S.M., Grdina, D.J. and Dolan, M.E. (1999) "Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity", Cancer Res. 59, 3059-3063.
113. Pasqualucci, L., Neumeister, P., Goossens, T., Nanjangud, G., Chaganti, R.S., Küppers, R. and Dalla-Favera, R. (2001) "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas", Nature 412, 341-346.
114. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project(1997), Blood 89, 3909-3918.
115. The International non-Hodgkin Lymphoma Prognostic Factor Proget: a predictive model for aggressive non-Hodgkin lymphoma(1993), N. Engl. J. Med. 329, 987-994.
116. Shipp, M.A., Ross, K.N., Tamayo, P., Weng, A.P., Kutok, J.L., Aguiar, R.C., Gaasenbeek, M., Angelo, M., Reich, M., Pinkus, G.S., Ray, T.S., Koval, M.A., Last, K.W., Norton, A., Lister, T.A., Mesirov, J., Neuberg, D.S., Lander, E.S., Aster, J.C. and Golub, T.R. (2002) "Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning", Nat. Med. 8, 68-74.
117. Lossos, I.S., Alizadeh, A.A., Eisen, M.B., Chan, W.C., Brown, P.O., Botstein, D., Staudt, L.M. and Levy, R. (2000) "Ongoing immunoglobulin somatic mutations in germinal center B cell like but not in activated B cell like diffuse large cell lymphomas", Proc. Nall. Acad. Sci. USA 97, 10202-10213.
118. Huang, J.Z., Sanger, W.G., Greiner, T.C., Staudt, L.M., Weisenburger, D.D., Pickering, D.L., Lynch, J.C., Armitage, J.O., Warnke, R.A., Alizadeh, A.A., Lossos, I.S., Levy, R. and Chan, W.C. (2002) "The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile", Blood 99, 2285-2290.
119. Ballerini, P, Gaidano, G., Gong, J.Z., Tassi, V., Saglio, G., Knowles, D.M. and Dalla-Favera, R. (1993) "Multiple genetic lesions in acquired immunodeficiency syndrome-related nonHodgkin lymphoma", Blood 81, 166-176.
120. Carbone, A., Tirelli, U., Gloghini, A., Volpe, R. and Boiocchi, M. (1993) "Human immunodeficiency virus associated systemic lymphomas may be subdivided into two main groups according to Epstein-Barr viral latent gene expression", J. Clin. Oncol. 11, 1674-1681.
121. Hamilton-Dutoit, S.J., Rea, D., Raphael, M., Sandvej, K., Delecluse, H.J., Gisselbrecht, C., Marelle, L., van Krieken, H.J. and Pallesen, G. (1993) "Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency", Am. J. Pathol. 143, 1072-1085.
122. Kulwichit, W., Edwards, R.H., Davenport, E.M., Baskar, J.F., Godfrey, V. and Raab-Traub, N. (1998) "Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphomas in transgenic mice", Proc. Natl. Acad. Sci. USA 95, 11963-11968.
123. Rothe, M., Sarma, V., Dixit, V.M. and Goeddel, D.V. (1995) "TRAF2 mediated activation of NF-kB by the TNF receptor 2 and CD40", Science 269, 1424-1427.
124. Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E. and Rickinson,,A. (1991) "Induction of BCL-2 expression by Epstein-Barr virus latent membrane protein-1 protects infected B cells from programmed cell death", Cell 65, 1107-1115.
125. Kersten, M.J., Klein, M.R., Holwerda, A.M., Miedema, F. and van Oers, M.H. (1997) "Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma", J. Clin. Invest. 99, 1525-1533.
126. Gaidano, G., Lo Coco, F., Ye, B.H., Shibata, D., Levine, A.M., Knowles, D.M. and Dalla-Favera, R. (1994) "Rearrangements of the BCL-6 gene in AIDS-associated non-Hodgkin lymphoma: association with diffuse large cell subtype", Blood 84, 397-402.
127. Gaidano, G., Pasqualucci, L., Vivenza, D., Deambrogi, C., Bertoncin, G., Berra, E., Capello, D., Rossi, D., Conconi, A., Gloghini, A., Saglio, G., Carbone, A. and Dalla-Favera, R. (2001) "Hypermutation of multiple proto-oncogenes in AIDS-related lymphoma", Blood 98, 503a.
128. Knowles, D.M., Cesarman, E., Chadburn, A., Frizzera, G., Chen, J., Rose, E.A. and Michler, R.E. (1995) "Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders", Blood 85, 552-565.
129. Tanner, J.E. and Alfieri, C. (2001) "The Epstein-Barr virus and post-transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis", Transpl. Infect. Dis. 3, 60-69.
130. Chadburn, A., Chen, J.M., Hsu, D.T., Frizzera, G., Cesarman, E., Garrett, T.J., Mears, J.G., Zangwill, S.D., Addonizio, L.J., Michler, R.E. and Knowles, D.M. (1998) "The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant", Cancer 82, 1978-1987.
131. Nelson, B.P., Nalesnik, M.A., Bahler, DW, Locker, J., Fung, J.J. and Swerdlow, S.H. (2000) "Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity?", Am. J. Surg. Pathol. 24, 375-385.
132. Delecluse, H.J., Rouault, J.P., Jeammot, B., Kremmer, E., Bastard, C. and Berger, F. (1995) "Bcl6/Laz3 rearrangements in post-transplant lymphoproliferative disorders", Br. J. Haematol. 91, 101-103.