BCL-6 gene mutations in posttransplantation lymphoproliferative disorders predict response to therapy and clinical outcome

Blood

Volumn 92, Issue 7, 1998, Pages 2294-2302

  Cesarman, Ethel ^a   Chadburn, Amy ^b   Liu, Yi Fang ^b   Migliazza, Anna ^b   Dalla Favera, Riccardo ^b   Knowles, Daniel M ^b  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DISEASE CLASSIFICATION; DRUG RESPONSE; EPSTEIN BARR VIRUS; GENE MUTATION; GENETIC POLYMORPHISM; HISTOPATHOLOGY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; PREDICTION; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0032189676     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.7.2294.2294_2294_2302     Document Type: Article

References (43)

1. Starzl TE, Nalesnik MA, Porter KA, Ho M, Iwatsuki S, Griffith BP, Rosenthal JT, Hakala TR, Shaw BWJ, Hardesty RL, Atchinson RW, Jaffe R, Bahnson HT: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1:583, 1984
2. Nalesnik MA, Jaffe R, Starzl TE, Demetris AJ, Porter K, Buraham JA, Makowka L, Ho M, Locker J: The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 133:173, 1988
3. Frizzera G, Hanto DW, Gajl-Peczalska KJ, Rosai J, McKenna RW, Sibley RK, Holahan KP, Lindquist LL: Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 41:4262, 1981
4. Cleary ML, Warnke R, Sklar J: Monoclonality of lymphoproliferative lesions in cardiac-transplant recipients. N Engl J Med 310:477, 1984
5. Cleary ML, Nalesnik MA, Shearer WT, Sklar J: Clonal analysis of transplant-associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus. Blood 72:349, 1988
6. Locker J, Nalesnik M: Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol 135:977, 1989
7. Cleary ML, Sklar J: Lymphoproliferative disorders in cardiac transplant recipients arc multiclonal lymphomas. Lancet ii:489, 1984
8. Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE: Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood 85:552, 1995
9. Chadburn A, Cesarman E, Knowles DM: Classification of post- transplantation lymphoproliferative disorders (PT-LPDs) based on morphologic and molecular genetic features has clinical relevance. Lab Invest 76:121 A, 1997 (abstr)
10. Chadburn A, Chen J, Hsu DT, Frizzera G, Cesarman E, Garrett TJ, Mears G, Zangwill S, Addonizio LJ, Michler RE, Knowles DM: The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant. Cancer 82:1978, 1998
11. Cattoretti G, Chang CC, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RS, Dalla-Favera R: BCL-6 protein is expressed in germinal-center B cells. Blood 86:45, 1995
12. Flenghi L, Ye BH, Fizzotti M, Bigerna B, Cattoretti G, Venturi S, Pacini R, Pileri S, Lo Coco F, Pescarmona E, Pelicci P-G, Dalla-Favera R, Falini B: A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol 147:405, 1995
13. Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato T, Ota H, Mori S: BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86:28, 1995
14. Allman D, Jain A, Dent A, Maile RR, Selvaggi T, Kehry MR, Staudt LM: BCL-6 expression during B-cell activation. Blood 87:5257, 1996
15. Seyfert VL, Allman D, He YS, Staudt LM: Transcriptional repression by the proto-oncogene BCL-6. Oncogene 12:2331, 1996
16. Chang CC, Ye BH, Chaganti RS, Dalla-Favera R: BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci USA 93:6947, 1996
17. Deweindt C, Albagli O, Bernardin F, Dhordain P, Quief S, Lantoine D, Kerckaert JP, Leprince D: The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: A novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ 6:1495, 1995
18. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM: Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276:589, 1997
19. Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall AM, Pandolfi P-P, Dalla-Favera R: The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16:161, 1997
20. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R: Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262:747, 1993
21. Baron BW, Nucifora G, McNabe N, Espinosa RI, LeBeau M, McKeithan TW: Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci USA 90:5262, 1993
22. Deweindt C, Kerckaert JP, Tilly H, Quief S, Nguyen VC, Bastard C: Cloning of a breakpoint cluster region at band 3q27 involved in human non-Hodgkin's lymphoma. Genes Chromosomes Cancer 8:149, 1993
23. Kerckaert J-P, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C: LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphoma. Nat Genet 5:66, 1993
24. Miki T, Kawamata N, Hirosawa S, Aoki N: Gene involved in the 3q27 translocation assoiated with B-cell lymphoma, BCL5, encodes a Krüpel-like zinc-finger protein. Blood 83:26, 1994
25. Lo Coco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM, Chaganti RS, Dalla-Favera R: Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 83:1757, 1994
26. Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H: LAZ3 rearrangements in non-Hodgkin's lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 83:2423, 1994
27. Otsuki T, Yano T, Clark HM, Bastard C, Kerckaert JP, Jaffe ES, Raffeld M: Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas: Results of rearrangement and gene expression studies and a mutational analysis of coding region sequences. Blood 85:2877, 1995
28. Gaidano G, Lo Coco F, Ye BH, Shibata D, Levine A, Knowles DM, Dalla-Favera R: Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: Association with diffuse large-cell subtype. Blood 15:397, 1994
29. Ye BH, Chaganti S, Chang CC, Niu H, Corradini P, Chaganti RS, Dalla-Favera R: Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J 14:6209, 1995
30. Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R: Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 92:12520, 1995
31. Gaidano G, Carbone A, Pastore C, Capello D, Migliazza A, Gloghini A, Roncella S, Ferrarini M, Saglio G, Dalla-Favera R: Frequent mutation of the 5′ noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. Blood 89:3755, 1997
32. Chen JM, Barr ML, Chadburn A, Frizzera G, Schenkel FA, Sciacca RR, Reison DS, Addonizio LJ, Rose EA, Knowles DM, Michler RE: Management of lymphoproliferative disorders after cardiac transplantation. Ann Thorac Surg (United States) 56:527, 1993
33. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215, 1988
34. SAS User's Guide, version 6. Cary, NC, SAS, 1990
35. Chadburn A, Cesarman E, Liu YF, Addonizio L, Hsu D, Michler RE, Knowles DM: Molecular genetic analysis demonstrates that multiple posttransplantation lymphoproliferative disorders occurring in one anatomic site in a single patient represent distinct primary lymphoid neoplasms. Cancer 75:2747, 1995
36. Frank D, Cesarman E, Liu YF, Michler RE, Knowles DM: Post-transplantation lymphoproliterative disorders frequently contain type A and not type B Epstein-Barr virus. Blood 85:1396, 1995
37. Scheinfeld AG, Nador RG, Cesarman E, Chadburn A, Knowles DM: Epstein-Barr virus latent membrane protein-1 oncogene deletion in post-transplantation lymphoproliferative disorders. Am J Pathol 151:805, 1997
38. Harris NL, Ferry JA, Swerdlow SH: Posttransplant lymphoproliferative disorders: Summary of Society for Hematopathology Workshop. Semin Diagn Pathol, 14:8, 1997
39. Cesarman E, Dalla-Favera R, Michler R, Knowles DM: Post- transplantation lymphoproliferative disorders (PT-LPDs) lack bcl-6 oncogene rearrangements. Lab Invest 72:107A, 1995 (abstr)
40. Flenghi L, Bigerna B, Fizzotti M, Venturi S, Pasqualucci L, Pileri S, Ye BH, Gambacorta M, Pacini R, Baroni CD, Pescarmona E, Anagnostopoulos I, Stein H, Asdrubali G, Martelli MF, Pelicci PG, Dalla-Favera R, Falini B: Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region. Am J Pathol 148:1543, 1996
41. Pescarmona E, Lo Coco F, Pacchiarotti A, Rapanotti MC, Cimino G, Di Paolo B, Baroni CD: Analysis of the BCL-6 gene configuration in diffuse B-cell non-Hodgkin's lymphomas and Hodgkin's disease. J Pathol 177:21, 1995
42. Kuppers R, Zhao M, Hansmann ML, Rajewsky K: Tracing B cell development in human geminal centres by molecular analysis of single cells picked from histological sections. EMBO J 12:4955, 1993
43. Miklos JA, Locker J, Bahler DW: Evidence for antigen selection in posttransplant lymphoproliferative disorders. Lab Invest 72:116A, 1995 (abstr)