Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas

Blood

Volumn 95, Issue 5, 2000, Pages 1797-1803

  Lossos, I S ^b   Okada, C Y ^b   Tibshirani, R ^b   Warnke, R ^b   Vose, J M ^b   Greiner, T C ^b   Levy, Ronald ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B CELL LYMPHOMA; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GERM LINE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; MAJOR CLINICAL STUDY; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROGNOSIS; SOMATIC MUTATION;

EID: 0034161392     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.5.1797.005k30_1797_1803     Document Type: Article

References (44)

1. Rajewsky K. Clonal selection and learning in the antibody system. Nature. 1996;381:751-758.
2. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today. 1995;16:237-242.
3. Cook GP, Tomlinson IM, Walter G, et al. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet. 1994;7:162-168.
4. Berek C. The development of B cells and the B-cell repertoire in the microenvironment of the germinal center. Immunol Rev. 1992;126:5-19.
5. Klein U, Goossens T, Fischer M, et al. Somatic hypermutation in normal and transformed human B cells. Immunol Rev. 1998;162:261-280.
6. Shlomchik M, Mascelli M, Shan H, et al. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med. 1990;171:265-292.
7. Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA. 1992;89:6770-6774.
8. Bahler DW, Zelenetz AD, Chen TT, Levy R. Antigen selection in human lymphomagenesis. Cancer Res. 1992;52:5547s-5551s.
9. Li Y, Spellerberg MB, Stevenson FK, Capra JD, Potter KN. The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J Mol Biol. 1996;256: 577-589.
10. Silverman GJ. Human antibody responses to bacterial antigens: studies of a model conventional antigen and a proposed model B cell superantigen. Int Rev Immunol. 1992;9:57-78.
11. Hsu FJ, Levy R. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood. 1995;86:3072-3082.
12. Daley MD, Berinstein NL, Siminovitch KA. Immunoglobulin heavy chain variable gene utilization in human large cell and Burkitt's lymphoma cell lines. Clin Invest Med. 1994;17:522-530.
13. Kuppers R, Rajewsky K, Hansmann ML. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol. 1997;27:1398-1405.
14. Stevenson FK, Spellerberg MB, Treasure J, et al. Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood. 1993;82:224-230.
15. Funkhouser WK, Wamke RA. Preferential IgH V4-34 gene segment usage in particular subtypes of B-cell lymphoma detected by antibody 9G4. Hum Pathol. 1998;29:1317-1321.
16. Rosenquist R, Lindstrom A, Holmberg D, Lindh J, Roos G. V(H) gene family utilization in different B-cell lymphoma subgroups. Eur J Haematol. 1999;62:123-128.
17. Taniguchi M, Oka K, Hiasa A, et al. De novo CD5+ diffuse large B-cell lymphomas express VH genes with somatic mutation. Blood. 1998;91:1145-1151.
18. Delecluse HJ, Hummel M, Marafioti T, Anagnostopoulos I, Stein H. Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern. J Pathol. 1999;188:133-138.
19. Gellrich S, Golembowski S, Audring H, Jahn S, Sterry W. Molecular analysis of the immunoglobulin VH gene rearrangement in a primary cutaneous immunoblastic B-cell lymphoma by micromanipulation and single-cell PCR. J Invest Dermatol. 1997;109:541-545.
20. Stiernholm N, Kuzniar B, Berinstein NL. Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation. Blood. 1992;80:738-743.
21. Ottensmeier CH, Thompsett AR, Zhu D, Wilkins BS, Sweetenham JW, Stevenson FK. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood. 1998:91:4292-4299.
22. van Belzen N, Hupkes PE, Doekharan D, Hoogeveen-Westerveld M, Dorssers LC, van't Veer MB. Detection of minimal disease using rearranged immunoglobulin heavy chain genes from intermediate- and high-grade malignant B cell non-Hodgkin's lymphoma. Leukemia. 1997;11:1742-1752.
23. Hyland J, Lasota J, Jasinski M, Petersen RO, Nordling S, Miettinen M. Molecular pathological analysis of testicular diffuse large cell lymphomas. Hum Pathol. 1998;29:1231-1239.
24. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]. Blood. 1994;84:1361-1392.
25. Campbell MJ, Zelenetz AD, Levy S, Levy R. Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol Immunol. 1992;29:193-203.
26. Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today. 1994;15:367-373.
27. Kneba M, Bergholz M, Bolz I, et al. Heterogeneity of immunoglobulin gene rearrangements in B-cell lymphomas. Int J Cancer. 1990;45:609-613.
28. Rassenti LZ, Kipps TJ. Lack of allelic exclusion in B cell chronic lymphocytic leukemia. J Exp Med. 1997;185:1435-1445.
29. Monni O, Joensuu H, Franssila K, Knuutila S. DNA copy number changes in diffuse large B-cell lymphoma - comparative genomic hybridization study. Blood. 1996;87:5269-5278.
30. Sklar J, Cleary ML, Thielemans K, Gralow J, Warnke R, Levy R. Biclonal B-cell lymphoma. N Engl J Med. 1984;311:20-27.
31. Logtenberg T, Schutte ME, Inghirami G, et al. Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia. Int Immunol. 1989;1:362-366.
32. Guigou V, Cuisinier AM, Tonnelle C, Moinier D, Fougereau M, Fumoux F. Human immunoglobulin VH and VK repertoire revealed by in situ hybridization. Mol Immunol. 1990;27:935-940.
33. Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol. 1995;155:190-202.
34. Bessudo A, Rassenti L, Havlir D, Richman D, Feigal E, Kipps TJ. Aberrant and unstable expression of immunoglobulin genes in persons infected with human immunodeficiency virus. Blood. 1998;92:1317-1323.
35. Stewart AK, Huang C, Stollar BD, Schwartz RS. High-frequency representation of a single VH gene in the expressed human B cell repertoire. J Exp Med. 1993;177:1227.
36. Stevenson FK, Smith GJ, North J, Hamblin TJ, Glennie MJ. Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-I specificity. Br J Haematol. 1989;72:9-15.
37. Kraj P, Friedman DF, Stevenson F, Silberstein LE. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol. 1995;154:6406-6420.
38. Nakamine H, Bagin RG, Vose JM, et al. Prognostic significance of clinical and pathologic features in diffuse large B-cell lymphoma. Cancer. 1993;71:3130-3137.
39. Frizzera G. Non-Hodgkin lymphomas: pathologic features and clinical correlations. In: Hoffman R, ed. Hematology: Basic Principles and Practice. New York: Churchill Livingstone; 1995:1247-1278.
40. Kon S, Levy S, Levy R. Retention of an idiotypic determinant in a human B-cell lymphoma undergoing immunoglobulin variable-region mutation. Proc Natl Acad Sci USA. 1987;84:5053-5057.
41. Cleary ML, Meeker TC, Levy S, et al. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cell. 1986;44:97-106.
42. Bahler DW, Campbell MJ, Hart S, Miller RA, Levy S, Levy R. Ig VH gene expression among human follicular lymphomas. Blood. 1991;78:1561-1568.
43. Thompsett AR, Ellison DW, Stevenson FK, Zhu D. V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity. Blood. 1999;94:1738-1746.
44. Driessen A, Tierens A, Ectors N, et al. Primary diffuse large B cell lymphoma of the stomach: analysis of somatic mutations in the rearranged immunoglobulin heavy chain variable genes indicates antigen selection. Leukemia. 1999;13:1085-1092.