Nonimmunoglobulin gene hypermutation in germinal center B cells

Blood

Volumn 93, Issue 7, 1999, Pages 2167-2172

  Peng, Huai Zheng ^b   Du, Ming Qing ^a   Koulis, Athanasios ^b   Aiello, Antonella ^b   Dogan, Ahmet ^b   Pan, Lang Xing ^b   Isaacson, Peter G ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B CELL LYMPHOMA; CARCINOGENESIS; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC LINKAGE; HUMAN; HUMAN TISSUE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; PRIORITY JOURNAL;

EID: 0033120450     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.7.2167.407a35_2167_2172     Document Type: Article

References (32)

1. Rajewsky K: Clonal selection and learning in the antibody system. Nature 381:751, 1996
2. Pascual V, Capra JD: Human Immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Advances in Immunology 49:1, 1991
3. Storb U: Progress in understanding the mechanism and consequences of somatic hypermutation. Immunol Rev 162:5, 1998
4. Dorner T, Foster SJ, Brezinschek H, Lipsky PE: Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distriburtion of nucleotide changes in human VHDJH rearrangements. Immunol Rev 162:161, 1998
5. Rogozin IB, Kolchanov NA: Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophys Acta 1171:11, 1992
6. Golding GB, Gearhart PJ, Glickman BW: Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115:169, 1987
7. Winter DB, Gearhart PJ: Dual enigma of somatic hypermutation of immunoglobulin variable genes: Targeting and mechanism. Immunol Rev 162:89, 1998
8. Storb U, Peters A, Klotz E, Kim N, Shen HM, Hackett J, Rogerson B, Martin TE: Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol Rev 153, 1998
9. Neuberger MS, Ehrenstein MR, Klix N, Jolly CJ, Yelamos J, Rada C, Milstein C: Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunol Rev 162:107, 1998
10. Pan LX, Diss TC, Peng HZ, Isaacson PG: Clonality analysis of defined B-cell populations in archival tissue sections using microdissection and the polymerase chain reaction. Histopathology 24:323, 1994
11. Diss TC, Peng HZ, Wotherspoon AC, Isaacson PG, Pan L: Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J Pathol 169:291, 1993
12. Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RS, Dalla Favera R: Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 92:12520, 1995
13. Peng H, Chen G, Du M, Singh N, Isaacson PG, Pan L: Replication error phenotype and p53 gene mutation in lymphomas of mucosa-associated lymphoid tissue. Am J Pathol 148:643, 1996
14. Migliazza A, Ye BH, Fracchiolla N, Neri A, Baldi L, Chaganti RSK, Dalla Favera R: Mutations of the 5′ non-coding region of the BCL-6 are common in B cell malignancies and can deregulate BCL-6 expression. Blood 90:780, 1997 (abstr)
15. Bernardin F, Collyn D, Quief S, Bastard C, Leprince D, Kerckaert JP: Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation. Oncogene 14:849, 1997
16. Dalla Favera R, Ye BH, Lo Coco F, Chang CC, Cechova K, Zhang J, Migliazza A, Mellado W, Niu H, Chaganti S, Chen W, Rao PH, Parsa NZ, Louie DL, Offit K, Chaganti RSK: BCL-6 and the molecular pathogenesis of B-cell lymphoma. Cold Spring Harb Symp Quant Biol 59:117, 1994
17. Otsuki T, Yano T, Clark HM, Bastard C, Kerckaert JP, Jaffe ES, Raffeld M: Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas: results ot rearrangement and gene expression studies and a mutational analysis of coding region sequences. Blood 85:2877, 1995
18. Klein U, Goossens T, Fischer M, Kanzler H, Braeuninger A, Rajewsky K, Kuppers R: Somatic hypermutation in normal and transformed human B cells. Immunol Rev 162:261, 1998
19. Ling LL, Keohavong P, Dias C, Thilly WG: Optimization of the polymerase chain reaction with regard to fidelity: modified T7, Taq, and vent DNA polymerases. PCR Methods Appl 1:63, 1991
20. Eckert KA, Kunkel TA: DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl 1:17, 1991
21. Kuppers R, Zhao M, Hansmann ML, Rajewsky K: Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 12:4955, 1993
22. Jacob J, Kelsoe G, Rajewsky K, Weiss U: Intraclonal generation of antibody mutants in germinal centres [see comments]. Nature 354:389, 1991
23. Kim N, Storb U: The role of DNA repair in somatic hypermutation of immunoglobulin genes. J Exp Med 187:1729, 1998
24. Wiesendanger M, Scharf MD, Edelmann W: Somatic hypermutation, transcription, and DNA mismatch repair. Cell 94:415, 1998
25. Kelsoe G: V(D)J hypermutation and DNA mismatch repair: Vexed by fixation. Proc Natl Acad Sci USA 95:6576, 1998
26. Shen HM, Peters A, Baron B, Zhu X, Storb U: Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutations of Ig genes. Science 280:1750, 1998
27. Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti RS, Klein U, Kuppers R, Rajewsky K, Dalla Favera R: BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA 95:11816, 1998
28. Zheng B, Xue W, Kelsoe G: Locus-specific somatic hypermutation in germinal centre T cells. Nature 372:556, 1994
29. Cheynier R, Henrichwark S, Wain Hobson S: Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients. Eur J Immunol 28:1604, 1998
30. Isaacson PG: Malignant lymphomas with a follicular growth pattern. Histopathology 28:487, 1996
31. Peng H, Du M, Diss TC, Isaacson PG, Pan L: Genetic evidence for a clonal link between low and high-grade components in gastric MALT B-cell lymphoma. Histopathology 30:425, 1997
32. Du M, Peng H, Singh N, Isaacson PG, Pan L: The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood 86:4587, 1995