BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma

Blood

Volumn 90, Issue 3, 1997, Pages 1168-1174

  Monni, Outi ^b   Joensuu, Heikki ^b   Franssila, Kaarle ^b   Klefstrom, Juha ^b   Alitalo, Kari ^b   Knuutila, Sakari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CELL ONCOGENE; CHROMOSOME 14Q; CHROMOSOME 18Q; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 18; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; IMMUNOGLOBULIN GENE; MALE; PRIORITY JOURNAL;

EID: 0030740592     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.3.1168.1168_1168_1174     Document Type: Article

References (35)

1. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14; 18) chromosome translocation. Science 226:1097, 1984
2. H on chromosome 14 and near a transcriptional unit on 18. Cell 41:899, 1985
3. Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce CM: The t(14; 18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229:1390, 1985
4. Cleary ML, Smith SD, Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14; 18) translocation. Cell 47:19, 1986
5. Ngan BY, Chen-Levy Z, Weiss LM, Wamke RA, Cleary ML: Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14; 18) chromosomal translocation. N Engl J Med 318:1638, 1988
6. Hockenbery D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334, 1990
7. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961, 1991
8. Weiss LM, Warnke RA, Sklar J, Cleary ML: Molecular analysis of the t(14; 18) chromosomal translocation in malignant lymphomas. N Engl J Med 317:1185, 1987
9. Aisenberg AC, Wilkes BM, Jacobson JO: The bcl-2 gene is rearranged in many diffuse B-cell lymphomas. Blood 71:969, 1988
10. Malignant lymphomas, in Heim S, Mitelman F (eds): Cancer Cytogenetics. New York, NY, Wiley-Liss, 1995, p 266
11. Graninger WB, Seto M, Boutain B, Goldman P, Korsmeyer SJ: Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. J Clin Invest 80:1512, 1987
12. Pezzella F, Tse AGD, Cordell JL, Pulford KAF, Gatter KC, Mason DY: Expression of the bcl-2 oncogene protein is not specific for the 14; 18 chromosomal translocation. Am J Pathol 137:225, 1990
13. Louie DC, Kant JA, Brooks JJ, Reed JC: Absence of t(14; 18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease. Am J Pathol 139:1231, 1991
14. Lambrechts AC, Looijenga LHJ, van't Veer MB, van Echten J, Timens W, Oosterhuis JW: Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14; 18): A molecular and immunohistochemical study. Br J Cancer 71:73, 1995
15. Alitalo K, Mäkelä TP, Saksela K, Koskinen P, Hirvonen H: Oncogene amplification: Analysis of myc oncoproteins, in Kellems R (ed): Gene Amplification in Mammalian Cells: Techniques and Applications. New York, NY, Marcel Dekker, 1992, p 371
16. Ben-Yehuda D, Houldsworth J, Parsa NZ, Chaganti RSK: Gene amplification in non-Hodgkin's lymphoma. Br J Haematol 86:792, 1994
17. Arranz E, Robledo M, Martínez B, Gallego J, Román A, Rivas C, Benítez J: Incidence of homogenously staining regions in non-Hodgkin lymphomas. Cancer Genet Cytogenet 87:1, 1996
18. Houldsworth J, Mathew S, Rao PH, Dyomina K, Louie DC, Parsa P, Offit K, Chaganti RSK: REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma. Blood 87:25, 1996
19. Monni O, Joensuu H, Franssila K, Knuutila S: DNA copy number changes in diffuse large B-cell lymphoma - Comparative genomic hybridization study. Blood 87:5269, 1996
20. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink HK, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361, 1994
21. Lukes RJ, Collins RD: Immunologic characterization of human malignant lymphomas. Cancer 34:1488, 1974
22. Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundström C, Van Unnik JAM, Wright DH: Updated Kiel classification for lymphomas. Lancet 1:292, 1988
23. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D: Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818, 1992
24. Szymanska J, Tarkkanen M, Wiklund T, Virolainen M, Blomqvist C, Asko-Seljavaara S, Tukiainen E, Elomaa I, Knuutila S: Gains and losses of sequences in liposarcomas evaluated by comparative genomic hybridization. Genes Chromosomes Cancer 15:89, 1996
25. El-Rifai W, Knuutila S: Fluorescent in situ hybridization on archival G-banded slides. Cytogenet Cell Genet 73:322, 1996
26. McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ: bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and folliculur lymphoproliferation. Cell 57:79, 1989
27. McDonnell TJ, Korsmeyer SJ: Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature 349:254, 1991
28. Tannapfel H, Kuhn R, Kessler H, Wittekind C: Expression of c-erbB2 oncogene product in different tumours and its standardised evaluation. Anal Cell Pathol 10:149, 1996
29. Tanaka S, Louie DC, Kant JA, Reed JC: Frequent incidence of somatic hypermutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. Blood 79:229, 1992
30. Taniwaki M, Sliverman GA, Nishida K, Horiike S, Misawa S, Shimazaki C, Miura I, Nagai M, Abe M, Fukuhara S, Kashima K: Translocations and amplification of the BCL2 gene are detected in interphase nuclei of non-Hodgkin's lymphoma by in situ hybridization with yeast artificial chromosome clones. Blood 86:1481, 1995
31. Hill ME, MacLennan KA, Cunningham DC, Vaughan Hudson B, Burke M, Clarke P, Stefano FD, Anderson L, Vaughan Hudson G, Mason D, Selby P, Linch DC: Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: A British national lymphoma investigation study. Blood 88:1046, 1996
32. Pettersson M, Jernberg-Wiklund H, Larsson LG, Sundström C, Givol I, Tsujimoto Y, Nilsson K: Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood 79:495, 1992
33. Kallioniemi OP, Kallioniemi A, Piper J, Isola J, Waldman FM, Gray JW, Pinkel D: Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer 10:231, 1994
34. Schouten HC, Sanger WG, Weisenburger DD, Anderson J, Armitage JO for the Nebraska Lymphoma Study Group: Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: Associations with histology, clinical characteristics, and treatment outcome. Blood 75:1841, 1990
35. Younes A, Jendiroba D, Engel H, Escudier S, Katz R, Rodriquez MA, Hill D, Cabanillas F, Andreeff M: High incidence of monosomy 18 in lymphoid malignancies that have bone marrow and peripheral blood involvement. Cancer Genet Cytogenet 77:39, 1994