De novo CD5+ diffuse large B-cell lymphomas express VH genes with somatic mutation

Blood

Volumn 91, Issue 4, 1998, Pages 1145-1151

  Taniguchi, Masanori ^a   Oka, Kouji ^a   Hiasa, Atsunori ^a   Yamaguchi, Motoko ^a   Ohno, Toshiyuki ^a   Kita, Kenkichi ^a   Shiku, Hiroshi ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD5 ANTIGEN;

ARTICLE; B CELL LYMPHOMA; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0032519558     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.4.1145     Document Type: Article

References (32)

1. Hardy RR, Hayakawa K: Development and physiology of LY-1 B and its human homolog, LEU-1 B. Immunol Rev 93:53,1986
2. Kipps TJ: The CD5 B cell. Adv lmmunol 47:117, 1989
3. Kantor AB: The development and repertoire of B-1 cells (CD5 B cells). Immunol Today 12:389, 1991
4. Kasaian MT, Ikematsu H, Casali P: CD5+ B lymphocytes. Proc Soc Exp Biol Med 197:226, 1991
5. Hayakawa K, Hardy RR, Honda M, Herzenberg LA, Steinberg AD, Herzenberg LA: Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci USA 81:2494, 1984
6. Hardy RR, Carmack CE, Shinton SA, Riblet RJ, Hayakawa K: A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells: Definition of the VH11 family. J Immunol 142:3643, 1989
7. Mantovani L, Wilder RL, Casali P: Human rheumatoid B-1a (CDS+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors. J Immunol 151:473, 1993
8. Ebeling SB, Schutte MEM, Logtenberg T: Peripheral human CDS+ and CD5-B cells may express somatically mutated VH5-and VH6-encoded IgM receptors. J Immunol 151:6891, 1993
9. Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet JL, and the French cooperative group on CLL: B-cell chronic Iymphocytic leukemia: Present status and future directions. Blood 78:1901, 1991
10. Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES, Mason D, Pileri S, Ralfkiaer E, Stein H, Warnke RA: Mantle cell lymphoma: A proposal for unification of morphologic, immunologie, and molecular data. Am J Surg Pathol 16:637, 1992
11. Burns BF Warnke RA, Doggett RS, Rouse RV: Expression of a T-cell antigen (Leu-1) by B-cell lymphomas. Am J Pathol 113:165, 1983
12. Matolcsy A, Inghirami G, Knowles DM: Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma). Blood 83:1363, 1994
13. Oka K, Ohno T, Kita K, Yamaguchi M, Takakura N, Nishii K, Miwa H, Shirakawa S: PRAD1 gene over-expression in mantle-cell lymphoma but not in other low-grade B-cell lymphomas, including extranodal lymphoma. Br J Haematol 86:786, 1994
14. Matolcsy A, Chadburn A, Knowles DM: De novo CDS-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct. Am J Pathol 147:207, 1995
15. Kipps TJ, Tomhave E, Chen PP, Carson DA: Autoantibody-associated K light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation: Implications for etiology and immunotherapy. J Exp Med 167:840, 1988
16. Meeker TC, Grimaldi JC, O'Rourke R, Loeb J, Juliusson G, Einhorn S: Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia. J Immunol 141:3994, 1988
17. Hummel M, Tamara J, Kalvelage B, Stein H: Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 84:403, 1994
18. Hashimoto S, Dono M, Wakai M, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Ferrarini M, Silver J, Chiorazzi N: Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells. J Exp Med 181:1507, 1995
19. Cai J, Humphries C, Richardson A, Tucker PW: Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia. J Exp Med 176:1073, 1992
20. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink H-K, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361, 1994
21. Qin Y, Greiner A, Trunk MJF, Schmausser B, Ott MM, Müller-Hermelink H-K: Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Blood 86:3528, 1995
22. Ramasamy I, Brisco M, Morley A: Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms. J Clin Pathol 45:770, 1992
23. Chang B, Casali P: The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 15:367, 1994
24. Tamaru J, Hummel M, Zemlin M, Kalvelage B, Stein H: Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes. Blood 84:708, 1994
25. Silberstein LE, Jefferies LC, Goldman J, Friedman D, Moore JS, Nowell PC, Roelcke D, Pruzanski W, Roudier J, Silverman GJ: Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood 78:2372, 1991
26. Stevenson FK, Spellerberg MB, Chapman CJ, Hamblin TJ: Differential usage of an autoantibody-associated VH gene, VH4-21, by human B-cell tumors. Leuk Lymphoma 16:379, 1995
27. Mageed RA, MacKenzie LE, Stevenson FK, Yuksel B, Shokri F, Maziak BR, Jefferis R, Lydyard PM: Selective expression of a VHIV subfamily of immunoglobulin genes in human CD5+ B lymphocytes from cord blood. J Exp Med 174:109, 1991
28. Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG: Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci USA 84:9150, 1987
29. Ng VL, Hurt MH, Fein CL, Khayam-Bashi F, Marsh J, Nunes WM, McPhaul LW, Feigal E, Nelson P, Herndier BG, Shiramizu B, Reyes GR, Fry KE, McGrath MS: IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation analysis. Blood 83:1067, 1994
30. Stoep N, Linden J, Logtenberg T: Molecular evolution of the human immunoglobulin E response: High incidence of shared mutations and clonal relatedness among e VH5 transcripts from three unrelated patients with atopic dermatitis. J Exp Med 177:99, 1993
31. Randen I, Brown D, Thompson KM, Hughes-Jones N, Pascual V, Victor K, Capra JD, Førre Ø, Natvig JB: Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol 148:3296, 1992
32. Zukerberg LR, Medeiros LJL, Ferry JA, Harris NL: Diffuse low-grade B-cell lymphomas: Four clinically distinct subtypes defined by a combination of morphologic and immunophenotypic features. Am J Clin Pathol 100:373, 1993