Analysis of the immunoglobulin heavy chain gene variable region of CD5-positive and -negative diffuse large B cell lymphoma

Leukemia

Volumn 15, Issue 3, 2001, Pages 452-457

  Nakamura, N ^a   Kuze, T ^a   Hashimoto, Y ^a   Hara, Y ^a   Hoshi, S ^a   Sasaki, Y ^a   Shirakawa, A ^a   Sato, M ^a   Abe, M ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

CD5; Diffuse large B cell lymphoma; Immunoglobulin heavy chain gene; Intraclonal diversity; PCR; Somatic mutation

Indexed keywords

CD5 ANTIGEN; DNA; IMMUNOGLOBULIN HEAVY CHAIN; NUCLEOTIDE;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LARGE CELL LYMPHOMA; LYMPHOCYTE SUBPOPULATION; MALE; MOLECULAR CLONING; MUTATION RATE; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 0035077707     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402031     Document Type: Article

References (38)

1. Somatic generation of antibody diversity
2. Mechanism of antigen-driven selection in germinal centers
3. Intraclonal generation of antibody mutants in germinal centers
4. The maturation of immune response
5. Molecular analysis of human immunoglobulin heavy chain variable gene (IgVH) in normal and malignant B cells
6. Somatic hypermutation in normal and transformed human B cells
7. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma
8. Analysis of the immunoglobulin heavy chain gene variable region of 101 cases with peripheral B cell neoplasms in the Japanese population
9. Differential rates of somatic hypermutation in VH genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities
10. Somatic hypermutation in the VH segment of immunoglobulin genes of CD5-positive diffuse large B cell lymphoma
11. + diffuse large B cell lymphomas express VH genes with somatic mutation
12. Analysis of the immunoglobulin heavy chain gene variable region of CD5-positive diffuse large B cell lymphoma
13. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells
14. Development and physiology of LY-1 B and its human homolog, Leu-1 B
15. De novo CD5-positive diffuse large B cell lymphoma: Clinical characteristics and therapeutic outcome
16. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma study group
17. Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicular mantle
18. Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies
19. + anaplastic large cell lymphoma of B cell type show a somatic mutation in the IgH V region genes
20. B cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B cell phenotypes
21. De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct
22. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma
23. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression
24. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
25. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
26. Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell
27. Clonal evolution of a follicular lymphoma: Evidence for antigen selection
28. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression
29. Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes
30. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
31. Immunoglobulin VH genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutation, and evidence of antigen-dependent affinity maturation
32. Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B cell lymphoma
33. Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation
34. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas
35. Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity
36. Malignant lymphoma of the gastrointestinal tract
37. Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: Evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis
38. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells