메뉴 건너뛰기




Volumn 48, Issue SUPPL. 1, 2001, Pages

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy

Author keywords

Acute myeloid leukemia; FLT3; Herbimycin A; HSP90; Molecule targeted therapy

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; BENZOQUINONE DERIVATIVE; CD135 ANTIGEN; ENZYME INHIBITOR; FLT3 PROTEIN, HUMAN; FLT3 PROTEIN, MOUSE; HEAT SHOCK PROTEIN 90; HERBIMYCIN; MACROCYCLIC LACTAM; ONCOPROTEIN; PROTEIN TYROSINE KINASE; QUINONE DERIVATIVE;

EID: 0002470404     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800100301     Document Type: Article
Times cited : (38)

References (35)
  • 1
    • 0027494860 scopus 로고
    • Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
    • Dosil M, Wang S, Lemischka IR (1993) Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells. Mol Cell Biol 13:6572
    • (1993) Mol Cell Biol , vol.13 , pp. 6572
    • Dosil, M.1    Wang, S.2    Lemischka, I.R.3
  • 2
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker BJ, Lydon NB (2000) Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 105:3
    • (2000) J Clin Invest , vol.105 , pp. 3
    • Druker, B.J.1    Lydon, N.B.2
  • 3
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y (1993) Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 92:1736
    • (1993) J Clin Invest , vol.92 , pp. 1736
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3    Ikeda, H.4    Kitayama, H.5    Koshimizu, U.6    Sugahara, H.7    Butterfield, J.H.8    Ashman, L.K.9    Kanayama, Y.10
  • 4
    • 0034677755 scopus 로고    scopus 로고
    • Mechanism-based target identification and drug discovery in cancer research
    • Gibbs JB (2000) Mechanism-based target identification and drug discovery in cancer research. Science 287:1969
    • (2000) Science , vol.287 , pp. 1969
    • Gibbs, J.B.1
  • 5
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG (1994) Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307
    • (1994) Cell , vol.77 , pp. 307
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 7
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T (2000) Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 19:624
    • (2000) Oncogene , vol.19 , pp. 624
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 8
    • 0034614490 scopus 로고    scopus 로고
    • Signalling - 2000 and beyond
    • Hunter T (2000) Signalling - 2000 and beyond. Cell 100:113
    • (2000) Cell , vol.100 , pp. 113
    • Hunter, T.1
  • 10
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T (1998) Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 12:1333
    • (1998) Leukemia , vol.12 , pp. 1333
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3    Hamaguchi, M.4    Ohno, R.5    Saito, H.6    Naoe, T.7
  • 12
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267:1782
    • (1995) Science , vol.267 , pp. 1782
    • Levitzki, A.1    Gazit, A.2
  • 13
    • 0034658153 scopus 로고    scopus 로고
    • STAT signaling in the pathogenesis and treatment of leukemias
    • Lin TS, Mahajan S, Frank DA (2000) STAT signaling in the pathogenesis and treatment of leukemias. Oncogene 19:2496
    • (2000) Oncogene , vol.19 , pp. 2496
    • Lin, T.S.1    Mahajan, S.2    Frank, D.A.3
  • 15
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
    • Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR (1991) A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143
    • (1991) Cell , vol.65 , pp. 1143
    • Matthews, W.1    Jordan, C.T.2    Wiegand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 16
    • 0033529033 scopus 로고    scopus 로고
    • Molecular chaperones: The busy life of Hsp90
    • Mayer MP, Bukau B (1999) Molecular chaperones: the busy life of Hsp90. Curr Biol 9:R322
    • (1999) Curr Biol , vol.9
    • Mayer, M.P.1    Bukau, B.2
  • 17
    • 0031733972 scopus 로고    scopus 로고
    • Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction
    • Murakami Y, Fukazawa H, Mizuno S, Uehara Y (1998) Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction. Biol Pharm Bull 21:1030
    • (1998) Biol Pharm Bull , vol.21 , pp. 1030
    • Murakami, Y.1    Fukazawa, H.2    Mizuno, S.3    Uehara, Y.4
  • 18
    • 0033043084 scopus 로고    scopus 로고
    • Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene
    • Nakano Y, Kiyoi H, Miyawaki S, Asou N, Ohno R, Saito H, Naoe T (1999) Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene. Br J Haematol 104:659
    • (1999) Br J Haematol , vol.104 , pp. 659
    • Nakano, Y.1    Kiyoi, H.2    Miyawaki, S.3    Asou, N.4    Ohno, R.5    Saito, H.6    Naoe, T.7
  • 20
    • 0029798251 scopus 로고    scopus 로고
    • Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis
    • Namikawa R, Muench MO, Roncarolo MG (1996) Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis. Stem Cells 14:388
    • (1996) Stem Cells , vol.14 , pp. 388
    • Namikawa, R.1    Muench, M.O.2    Roncarolo, M.G.3
  • 21
    • 0025870946 scopus 로고
    • Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
    • Rosnet O, Marchetto S, de Lapeyriere O, Birnbaum D (1991) Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene 6:1641
    • (1991) Oncogene , vol.6 , pp. 1641
    • Rosnet, O.1    Marchetto, S.2    De Lapeyriere, O.3    Birnbaum, D.4
  • 23
    • 0034644539 scopus 로고    scopus 로고
    • Cell signalling by receptor tyrosine kinases
    • Schlessinger J (2000) Cell signalling by receptor tyrosine kinases. Cell 103:211
    • (2000) Cell , vol.103 , pp. 211
    • Schlessinger, J.1
  • 25
    • 0032554763 scopus 로고    scopus 로고
    • Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol
    • Sharma SV, Agatsuma T, Nakano H (1998) Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. Oncogene 16:2639
    • (1998) Oncogene , vol.16 , pp. 2639
    • Sharma, S.V.1    Agatsuma, T.2    Nakano, H.3
  • 26
    • 0034665760 scopus 로고    scopus 로고
    • Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
    • Shiotsu Y, Neckers LM, Wortman I, An W, Schulte TW, Soga S, Murakata C, Tamaoki T, Akinaga S (2000) Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Blood 96:2284
    • (2000) Blood , vol.96 , pp. 2284
    • Shiotsu, Y.1    Neckers, L.M.2    Wortman, I.3    An, W.4    Schulte, T.W.5    Soga, S.6    Murakata, C.7    Tamaoki, T.8    Akinaga, S.9
  • 27
    • 0027955112 scopus 로고
    • STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
    • Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM (1994) STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 459
    • Small, D.1    Levenstein, M.2    Kim, E.3    Carow, C.4    Amin, S.5    Rockwell, P.6    Witte, L.7    Burrow, C.8    Ratajczak, M.Z.9    Gewirtz, A.M.10
  • 29
    • 0031005361 scopus 로고    scopus 로고
    • Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
    • Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP (1997) Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 89:239
    • (1997) Cell , vol.89 , pp. 239
    • Stebbins, C.E.1    Russo, A.A.2    Schneider, C.3    Rosen, N.4    Hartl, F.U.5    Pavletich, N.P.6
  • 30
    • 0025276780 scopus 로고
    • Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia
    • Tobal K, Pagliuca A, Bhatt B, Bailey N, Layton DM, Mufti GJ (1990) Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 4:486
    • (1990) Leukemia , vol.4 , pp. 486
    • Tobal, K.1    Pagliuca, A.2    Bhatt, B.3    Bailey, N.4    Layton, D.M.5    Mufti, G.J.6
  • 31
    • 0021932292 scopus 로고
    • Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': Identification of an active agent as herbimycin and its inhibition of intracellular src kinase
    • Uehara Y, Hori M, Takeuchi T, Umezawa H (1985) Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase. Jpn J Cancer Res 76:672
    • (1985) Jpn J Cancer Res , vol.76 , pp. 672
    • Uehara, Y.1    Hori, M.2    Takeuchi, T.3    Umezawa, H.4
  • 32
    • 0023940887 scopus 로고
    • Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A
    • Uehara Y, Murakami Y, Mizuno S, Kawai S (1988) Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A. Virology 164:294
    • (1988) Virology , vol.164 , pp. 294
    • Uehara, Y.1    Murakami, Y.2    Mizuno, S.3    Kawai, S.4
  • 34
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, Iwai T, Misawa S, Okuda T, Sonoda Y, Abe T, Kashima K, Matsuo Y, Naoe T (1997) Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia 11:1605
    • (1997) Leukemia , vol.11 , pp. 1605
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3    Iwai, T.4    Misawa, S.5    Okuda, T.6    Sonoda, Y.7    Abe, T.8    Kashima, K.9    Matsuo, Y.10    Naoe, T.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.