-
1
-
-
0027494860
-
Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
-
Dosil M, Wang S, Lemischka IR (1993) Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells. Mol Cell Biol 13:6572
-
(1993)
Mol Cell Biol
, vol.13
, pp. 6572
-
-
Dosil, M.1
Wang, S.2
Lemischka, I.R.3
-
2
-
-
0033987746
-
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
-
Druker BJ, Lydon NB (2000) Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 105:3
-
(2000)
J Clin Invest
, vol.105
, pp. 3
-
-
Druker, B.J.1
Lydon, N.B.2
-
3
-
-
0027359443
-
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
-
Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y (1993) Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 92:1736
-
(1993)
J Clin Invest
, vol.92
, pp. 1736
-
-
Furitsu, T.1
Tsujimura, T.2
Tono, T.3
Ikeda, H.4
Kitayama, H.5
Koshimizu, U.6
Sugahara, H.7
Butterfield, J.H.8
Ashman, L.K.9
Kanayama, Y.10
-
4
-
-
0034677755
-
Mechanism-based target identification and drug discovery in cancer research
-
Gibbs JB (2000) Mechanism-based target identification and drug discovery in cancer research. Science 287:1969
-
(2000)
Science
, vol.287
, pp. 1969
-
-
Gibbs, J.B.1
-
5
-
-
0028224348
-
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
-
Golub TR, Barker GF, Lovett M, Gilliland DG (1994) Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307
-
(1994)
Cell
, vol.77
, pp. 307
-
-
Golub, T.R.1
Barker, G.F.2
Lovett, M.3
Gilliland, D.G.4
-
6
-
-
0027957296
-
Acute promyelocytic leukemia: From genetics to treatment
-
Grignani F, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo CF, Grignani F, Pelicci PG (1994) Acute promyelocytic leukemia: from genetics to treatment. Blood 83:10
-
(1994)
Blood
, vol.83
, pp. 10
-
-
Grignani, F.1
Fagioli, M.2
Alcalay, M.3
Longo, L.4
Pandolfi, P.P.5
Donti, E.6
Biondi, A.7
Lo, C.F.8
Grignani, F.9
Pelicci, P.G.10
-
7
-
-
0034598830
-
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
-
Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T (2000) Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 19:624
-
(2000)
Oncogene
, vol.19
, pp. 624
-
-
Hayakawa, F.1
Towatari, M.2
Kiyoi, H.3
Tanimoto, M.4
Kitamura, T.5
Saito, H.6
Naoe, T.7
-
8
-
-
0034614490
-
Signalling - 2000 and beyond
-
Hunter T (2000) Signalling - 2000 and beyond. Cell 100:113
-
(2000)
Cell
, vol.100
, pp. 113
-
-
Hunter, T.1
-
9
-
-
16944362760
-
Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
-
Kiyoi H, Naoe T, Yokota S, Nakao M, Minami S, Kuriyama K, Takeshita A, Saito K, Hasegawa S, Shimodaira S (1997) Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia 11:1447
-
(1997)
Leukemia
, vol.11
, pp. 1447
-
-
Kiyoi, H.1
Naoe, T.2
Yokota, S.3
Nakao, M.4
Minami, S.5
Kuriyama, K.6
Takeshita, A.7
Saito, K.8
Hasegawa, S.9
Shimodaira, S.10
-
10
-
-
0031686409
-
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
-
Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T (1998) Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 12:1333
-
(1998)
Leukemia
, vol.12
, pp. 1333
-
-
Kiyoi, H.1
Towatari, M.2
Yokota, S.3
Hamaguchi, M.4
Ohno, R.5
Saito, H.6
Naoe, T.7
-
11
-
-
0033134792
-
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
-
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C (1999) Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 93:3074
-
(1999)
Blood
, vol.93
, pp. 3074
-
-
Kiyoi, H.1
Naoe, T.2
Nakano, Y.3
Yokota, S.4
Minami, S.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Jinnai, I.9
Shimazaki, C.10
-
12
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki A, Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267:1782
-
(1995)
Science
, vol.267
, pp. 1782
-
-
Levitzki, A.1
Gazit, A.2
-
13
-
-
0034658153
-
STAT signaling in the pathogenesis and treatment of leukemias
-
Lin TS, Mahajan S, Frank DA (2000) STAT signaling in the pathogenesis and treatment of leukemias. Oncogene 19:2496
-
(2000)
Oncogene
, vol.19
, pp. 2496
-
-
Lin, T.S.1
Mahajan, S.2
Frank, D.A.3
-
14
-
-
0027146421
-
Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells
-
Lyman SD, James L, Vanden Bos T, de Vries P, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR (1993) Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell 75:1157
-
(1993)
Cell
, vol.75
, pp. 1157
-
-
Lyman, S.D.1
James, L.2
Vanden Bos, T.3
De Vries, P.4
Brasel, K.5
Gliniak, B.6
Hollingsworth, L.T.7
Picha, K.S.8
McKenna, H.J.9
Splett, R.R.10
-
15
-
-
0025770646
-
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
-
Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR (1991) A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143
-
(1991)
Cell
, vol.65
, pp. 1143
-
-
Matthews, W.1
Jordan, C.T.2
Wiegand, G.W.3
Pardoll, D.4
Lemischka, I.R.5
-
16
-
-
0033529033
-
Molecular chaperones: The busy life of Hsp90
-
Mayer MP, Bukau B (1999) Molecular chaperones: the busy life of Hsp90. Curr Biol 9:R322
-
(1999)
Curr Biol
, vol.9
-
-
Mayer, M.P.1
Bukau, B.2
-
17
-
-
0031733972
-
Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction
-
Murakami Y, Fukazawa H, Mizuno S, Uehara Y (1998) Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction. Biol Pharm Bull 21:1030
-
(1998)
Biol Pharm Bull
, vol.21
, pp. 1030
-
-
Murakami, Y.1
Fukazawa, H.2
Mizuno, S.3
Uehara, Y.4
-
18
-
-
0033043084
-
Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene
-
Nakano Y, Kiyoi H, Miyawaki S, Asou N, Ohno R, Saito H, Naoe T (1999) Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene. Br J Haematol 104:659
-
(1999)
Br J Haematol
, vol.104
, pp. 659
-
-
Nakano, Y.1
Kiyoi, H.2
Miyawaki, S.3
Asou, N.4
Ohno, R.5
Saito, H.6
Naoe, T.7
-
19
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao H, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, Sonoda Y, Fujimoto T, Misawa S (1996) Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 10:1911
-
(1996)
Leukemia
, vol.10
, pp. 1911
-
-
Nakao, H.1
Yokota, S.2
Iwai, T.3
Kaneko, H.4
Horiike, S.5
Kashima, K.6
Sonoda, Y.7
Fujimoto, T.8
Misawa, S.9
-
20
-
-
0029798251
-
Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis
-
Namikawa R, Muench MO, Roncarolo MG (1996) Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis. Stem Cells 14:388
-
(1996)
Stem Cells
, vol.14
, pp. 388
-
-
Namikawa, R.1
Muench, M.O.2
Roncarolo, M.G.3
-
21
-
-
0025870946
-
Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
-
Rosnet O, Marchetto S, de Lapeyriere O, Birnbaum D (1991) Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene 6:1641
-
(1991)
Oncogene
, vol.6
, pp. 1641
-
-
Rosnet, O.1
Marchetto, S.2
De Lapeyriere, O.3
Birnbaum, D.4
-
22
-
-
0027301288
-
Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
-
Rosnet O, Schiff C, Pebusque MJ, Marchetto S, Tonnelle C, Toiron Y, Birg F, Birnbaum D (1993) Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood 82:1110
-
(1993)
Blood
, vol.82
, pp. 1110
-
-
Rosnet, O.1
Schiff, C.2
Pebusque, M.J.3
Marchetto, S.4
Tonnelle, C.5
Toiron, Y.6
Birg, F.7
Birnbaum, D.8
-
23
-
-
0034644539
-
Cell signalling by receptor tyrosine kinases
-
Schlessinger J (2000) Cell signalling by receptor tyrosine kinases. Cell 103:211
-
(2000)
Cell
, vol.103
, pp. 211
-
-
Schlessinger, J.1
-
24
-
-
0029813620
-
Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
-
Schulte TW, Blagosklonny MV, Romanova L, Mushinski JF, Monia BP, Johnston JF, Nguyen P, Trepel J, Neckers LM (1996) Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. Mol Cell Biol 16:5839
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5839
-
-
Schulte, T.W.1
Blagosklonny, M.V.2
Romanova, L.3
Mushinski, J.F.4
Monia, B.P.5
Johnston, J.F.6
Nguyen, P.7
Trepel, J.8
Neckers, L.M.9
-
25
-
-
0032554763
-
Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol
-
Sharma SV, Agatsuma T, Nakano H (1998) Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. Oncogene 16:2639
-
(1998)
Oncogene
, vol.16
, pp. 2639
-
-
Sharma, S.V.1
Agatsuma, T.2
Nakano, H.3
-
26
-
-
0034665760
-
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
-
Shiotsu Y, Neckers LM, Wortman I, An W, Schulte TW, Soga S, Murakata C, Tamaoki T, Akinaga S (2000) Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Blood 96:2284
-
(2000)
Blood
, vol.96
, pp. 2284
-
-
Shiotsu, Y.1
Neckers, L.M.2
Wortman, I.3
An, W.4
Schulte, T.W.5
Soga, S.6
Murakata, C.7
Tamaoki, T.8
Akinaga, S.9
-
27
-
-
0027955112
-
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
-
Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM (1994) STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 459
-
-
Small, D.1
Levenstein, M.2
Kim, E.3
Carow, C.4
Amin, S.5
Rockwell, P.6
Witte, L.7
Burrow, C.8
Ratajczak, M.Z.9
Gewirtz, A.M.10
-
28
-
-
0031984520
-
Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway
-
Soga S, Kozawa T, Narumi H, Akinaga S, Irie K, Matsumoto K, Sharma SV, Nakano H, Mizukami T, Hara M (1998) Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway. J Biol Chem 273:822
-
(1998)
J Biol Chem
, vol.273
, pp. 822
-
-
Soga, S.1
Kozawa, T.2
Narumi, H.3
Akinaga, S.4
Irie, K.5
Matsumoto, K.6
Sharma, S.V.7
Nakano, H.8
Mizukami, T.9
Hara, M.10
-
29
-
-
0031005361
-
Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
-
Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP (1997) Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 89:239
-
(1997)
Cell
, vol.89
, pp. 239
-
-
Stebbins, C.E.1
Russo, A.A.2
Schneider, C.3
Rosen, N.4
Hartl, F.U.5
Pavletich, N.P.6
-
30
-
-
0025276780
-
Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia
-
Tobal K, Pagliuca A, Bhatt B, Bailey N, Layton DM, Mufti GJ (1990) Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 4:486
-
(1990)
Leukemia
, vol.4
, pp. 486
-
-
Tobal, K.1
Pagliuca, A.2
Bhatt, B.3
Bailey, N.4
Layton, D.M.5
Mufti, G.J.6
-
31
-
-
0021932292
-
Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': Identification of an active agent as herbimycin and its inhibition of intracellular src kinase
-
Uehara Y, Hori M, Takeuchi T, Umezawa H (1985) Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase. Jpn J Cancer Res 76:672
-
(1985)
Jpn J Cancer Res
, vol.76
, pp. 672
-
-
Uehara, Y.1
Hori, M.2
Takeuchi, T.3
Umezawa, H.4
-
32
-
-
0023940887
-
Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A
-
Uehara Y, Murakami Y, Mizuno S, Kawai S (1988) Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A. Virology 164:294
-
(1988)
Virology
, vol.164
, pp. 294
-
-
Uehara, Y.1
Murakami, Y.2
Mizuno, S.3
Kawai, S.4
-
33
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematological malignancies
-
Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Teda R, Ohno R, Naoe T (2001) Activating mutation of D835 within the activation loop of FLT3 in human hematological malignancies. Blood 97:2434
-
(2001)
Blood
, vol.97
, pp. 2434
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
Suzuki, R.4
Kodera, Y.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Yagasaki, F.9
Shimazaki, C.10
Akiyama, H.11
Saito, K.12
Nishimura, M.13
Motoji, T.14
Shinagawa, K.15
Takeshita, A.16
Saito, H.17
Teda, R.18
Ohno, R.19
Naoe, T.20
more..
-
34
-
-
16944365287
-
Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines
-
Yokota S, Kiyoi H, Nakao M, Iwai T, Misawa S, Okuda T, Sonoda Y, Abe T, Kashima K, Matsuo Y, Naoe T (1997) Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia 11:1605
-
(1997)
Leukemia
, vol.11
, pp. 1605
-
-
Yokota, S.1
Kiyoi, H.2
Nakao, M.3
Iwai, T.4
Misawa, S.5
Okuda, T.6
Sonoda, Y.7
Abe, T.8
Kashima, K.9
Matsuo, Y.10
Naoe, T.11
-
35
-
-
0034093724
-
In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor
-
Zhao M, Kiyoi H, Yamamoto Y, Ito M, Towatari M, Omura S, Kitamura T, Ueda R, Saito H, Naoe T (2000) In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor. Leukemia 14:374
-
(2000)
Leukemia
, vol.14
, pp. 374
-
-
Zhao, M.1
Kiyoi, H.2
Yamamoto, Y.3
Ito, M.4
Towatari, M.5
Omura, S.6
Kitamura, T.7
Ueda, R.8
Saito, H.9
Naoe, T.10
|