Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children

British Journal of Haematology

Volumn 105, Issue 1, 1999, Pages 155-162

  Xu, F ^d   Taki, T ^d   Yang, H W ^d   Hanada, R ^a   Hongo, T ^b   Ohnishi, H ^d   Kobayashi, M ^d   Bessho, F ^d   Yanagisawa, M ^d   Hayashi, Yasuhide ^c  

^a SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NONE

Author keywords

Acute leukaemia; FLT3 gene; Prognosis; RT PCR; Tandem duplication

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHILD; CHRONIC MYELOID LEUKEMIA; EXON; GENE DUPLICATION; GENE LOCATION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TANDEM REPEAT;

ACUTE DISEASE; ADOLESCENT; AMINO ACID SEQUENCE; CHILD; CHILD, PRESCHOOL; FEMALE; FMS-LIKE TYROSINE KINASE 3; GENE DUPLICATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; LEUKEMIA, MYELOID, CHRONIC; MALE; MOLECULAR SEQUENCE DATA; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0001097136     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.1999.01284.x     Document Type: Article

References (38)

1. Agnes, F., Shamoon, B., Dina, C., Rosnet, O., Birnbaum, D. & Galibert, F. (1994) Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III. Gene, 145, 281-288.
2. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A., Gralnick, H.R. & Sultan, C. (1981) The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. British Journal Haematology, 47, 553-561.
3. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Glalnick, H.R. & Sultan, C. (1985) Proposed revised criteria for the classification of acute myeloid leukemia: a report of the French-American-British cooperative group. Annals of Internal Medicine, 103, 626-629.
4. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R. & Sultan, C. (1991) Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-MO). British Journal of Haematology, 78, 325-329.
5. Birg, F., Courcoul, M., Rosnet, O., Bardin, F., Pebusque, M-J., Marchetto, S., Tabilio, A., Mannoni, P. & Birnbaum, D. (1992) Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood, 80, 2584-2593.
6. Brasel, K., Escobar, S., Anderberg, R., de Vries, P., Gruss, H.-J. & Lyman, S.D. (1995) Expression of the flt3 receptor and its ligand on hematopoietic cells. Leukemia, 9, 1212-1218.
7. Carow, C.E., Levenstein, M., Kaufmann, S.H., Chen, J., Amin, S., Rockwell, P., Witte, L., Borowitz, M.J., Civin, C.I. & Small, D. (1996) Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood, 87, 1089-1096.
8. Chomczynski, P. & Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
9. Da Silva, N., Hu, Z.B., Ma, W., Rosnet, O., Birnbaum, D. & Drexler, H.G. (1994) Expression of the FLT3 gene in human leukemia-lymphoma cell lines. Leukemia, 8, 885-888.
10. Dehmel, U., Zaborski, M., Meierhoff, G., Rosnet, O., Birnbaum, D., Ludwig, W.D., Quentmeier, H. & Drexler, H.G. (1996) Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells. Leukemia, 10, 261-270.
11. Drexter, H.G. (1996) Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia, 10, 588-599.
12. Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Zurawski, S., Bazan, J.F., Kastelein, R., Hudak, S., Wagner, J., Mattson, J., Luh, J., Duda, G., Martina, N., Peterson, D., Menon, S., Shanafelt, A., Muench, M., Keiner, G., Namikawa, R., Rennick, D. & Lee, F. (1994) Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature, 368, 643-648.
13. Hayashi, Y., Kawamura, M., Kobayashi, S., Moriwaki, K., Kobayashi, M., Bessho, F., Hanada, R., Yamamoto, K., Mori, T., Nakazawa, S., Yaginuma, Y., Honma, Y. & Hozumi, M. (1993) Establishment and characterization of cell lines derived from childhood leukemias. International Journal of Hematology. 57, (Suppl.), 124.
14. Horiike, S., Yokota, S., Nakao, M., Iwai, T., Sasai, Y., Kancko, H., Taniwaki, M., Kashima, K., Fujii, H., Abe, T. & Misawa, S. (1997) Tandem duplication of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia, 11, 1442-1446.
15. Ida, K., Kitabayashi, I., Taki, T., Taniwaki, M., Noro, K., Yamamoto, M., Ohki, M. & Hayashi, Y. (1997) Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with 1(11;22)(q23;q13). Blood, 90, 4699-4704.
16. Kawamura, M., Kikuchi, A., Kobayashi, S., Hanada, R., Yamamoto, K., Horibe, K., Shikano, T., Ueda, K., Hayashi, K., Sekiya, T. & Hayashi, Y. (1995) Mutations of the p53 and ras genes in childhood 1(1;19)-acute lymphoblastic leukemia. Blood, 85, 2546-2552.
17. Kiyoi, H., Naoe, T., Yokota, S., Nakao, M., Minami, S., Kuriyama, K., Takeshita, A., Saito, K., Hasegawa, S., Shimodaira, S., Tamura, J., Shimazaki, C., Matsue, K., Kobayashi, H., Arima, N., Suzuki, R., Morishita, H., Saito, H., Ueda, R. & Ohno, R., and the Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho) (1997) Internal tandem duplication of FLT3 associated with leukocytosis in acute promyclocytic leukemia. Leukemia, 11, 1447-1452.
18. Kong, XT., Ida, K., Ichikawa, H., Shimizu, K., Ohki, M., Maseki, N., Kaneko, Y., Sako, M., Kobayashi, Y., Tojou, A., Miura, I., Kakuda, H., Funabiki, T., Horibe, K., Hamaguchi, H., Akiyama, Y., Bessho, F., Yanagisawa, M. & Hayashi, Y. (1997) Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood, 90, 1192-1199.
19. Lyman, S.D., James, L., Vanden Bos, T., De Vries, P., Brasel, K. Gliniak, B., Hollingsworth, L.T., Picha, K.S., Mekenna, H.J., Splett, R.R., Fletcher, F.A., Maraskovsky, E., Farrah, T., Foxworthe, D., Williams, D.E. & Beckmann, M.P. (1993a) Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell, 75, 1157-1167.
20. Lyman, S.D., Mames, L., Zappone, J., Sleath, P.R., Beckmann, M.P. & Bird, T. (1993b) Characterization of the protein encoded by the flt3(flk2) receptor-like tyrosine kinase gene. Oncogene, 8, 815-822.
21. Matthews, W., Jordan, C.T., Wiegand, G.W., Pardoll, D. & Lemischka, I.R. (1991) A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell, 65, 1143-1152.
22. Mckenna, H.J., Smith, F.O., Brasel, K., Hirschstein, D., Bernstein, I.D., Williams, D.E. & Lyman, S.D. (1996) Effects of flt3 ligand on acute myeloid and lymphocytic leukemia blast cells from children. Experimental Hematology, 24, 378-385.
23. Meierhoff, G., Dehmel, U., Gruss, H-J., Rosnet, O., Birnbaum, D., Quentmeier, H., Dirks, W. & Drexler, H.G. (1995) Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines. Leukemia, 9, 1368-1372.
24. Nakao, M., Yokota, S., Iwai, T., Kaneko, H., Horiike, S., Kashima, K., Sonoda, Y., Fujimoto, T. & Misawa, S. (1996) Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia, 10, 1911-1918.
25. Ohnishi, H., Hanada, R., Horibe, K., Hongo, T., Kawamura, M., Naritaka, S., Bessho, F., Yanagisawa, M., Nobori, T., Yamamori, S. & Hayashi, Y. (1996) Homozygous deletion of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B-precursor acute lymphoblastic leukemia (ALL) in childhood. Leukemia, 10, 1104-1110.
26. Ohnishi, H., Kawamura, M., Ida, K., Sheng, X.M., Hanada, R., Nobori, T., Yamamori, S. & Hayashi, Y. (1995) Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. Blood, 86, 1269-1275.
27. Piacibello, W., Fubini, L., Sanavio, F., Brizzi, M.F., Severino, A., Garetto, L., Stacchini, A., Pegoraro, L. & Aglietta, M. (1995) Effects of human FLT3 ligand on myeloid leukemia cell growth: heterogeneity in response and synergy with other hematopoietic growth factors. Blood, 86, 4105-4114.
28. Rosnet, O., Marchetto, S., delapeyriere, O. & Birnbaum D. (1991a) Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSFIR family. Oncogene, 6, 1641-1650.
29. Rosnet, O., Mattei, M.G., Marchetto, S. & Birnbaum, D. (1991b) Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. Genomics, 9, 380-385.
30. Rosnet, O., Schiff, C., Pebusque, M-J., Marchetto, S., Toiron, Y., Birg, F. & Birnbaum, D. (1993) Human FLT3/FLT2 gene: cDNA cloning and expression in hematopoietic cells. Blood, 82, 1110-1119.
31. Rossner, M.T., McArthur, G.A., Allen, J.D. & Metcalf, D. (1994) Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDC-P1 cells that is qualitatively similar to the signal delivered by c-Fms. Cell Growth and Differentiation, 5, 549-555.
32. + bone marrow progenitor cells in vitro. Blood, 87, 1317-1325.
33. Sherr, C. (1990) Colony-stimulating factor-1 receptor. Blood, 75, 1-12.
34. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proceedings of the National Academy of Sciences of the United States of America, 91, 459-463.
35. Stacchini, A., Fubini, L., Severino, A., Sanavio, F., Aglietta, M. & Piacibello, W. (1996) Expression of type III receptor tyrosine kinases FLT3 and KIT and responses to their ligands by acute leukemia blasts. Leukemia, 10, 1584-1591.
36. Taki, T., Sako, M., Tsuchida, M. & Hayashi, Y. (1997) The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene. Blood, 89, 3945-3950.
37. Williams, D., Vries, P., Namen, A., Widmer, M. & Lyman, S. (1992) The Steel factor. Developmental Biology, 151, 368-376.
38. Yokota, S., Kiyoi, H., Nakao, M., Iwai, T., Misawa, S., Okuda, T., Sonodo, Y., Abe, T., Kahsima, K., Matsuo, Y. & Naoe, T. (1997) Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia, 11, 1605-1609.