Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

Journal of Clinical Investigation

Volumn 108, Issue 9, 2001, Pages 1321-1330

  He, Li Zhen ^a   Tolentino, Thomas ^a   Grayson, Peter ^a   Zhong, Sue ^a   Warrell Jr , Raymond P ^b   Rifkind, Richard A ^a   Marks, Paul A ^a   Richon, Victoria M ^a   Pandolfi, Pier Paolo ^a,c  

^a Weill Cornell Medical Center   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLBUTYRIC ACID DERIVATIVE; GENE PRODUCT; HISTONE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; ONCOPROTEIN; PROTEIN PLZF; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 17; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SENSITIVITY; FUSION GENE; GENE LOCUS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA REMISSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TARGET ORGAN; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; DNA, COMPLEMENTARY; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IN SITU NICK-END LABELING; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENYLBUTYRATES; PROTEIN BINDING; RECEPTORS, RETINOIC ACID; REMISSION INDUCTION; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0035189761     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200111537     Document Type: Article

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