NFκB-dependent chemoresistance in solid tumors

International Journal of Clinical Pharmacology and Therapeutics

Volumn 40, Issue 8, 2002, Pages 336-347

  Arlt, A ^a   Schafer H ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Chemotherapy; DNA damage; Programmed cell death; Transcription factor

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BORTEZOMIB; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FAS ANTIGEN; FLUOROURACIL; GEMCITABINE; GLUCOCORTICOID; GYRASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; IRINOTECAN; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; PREDNISONE; PROTEASOME INHIBITOR; RESVERATROL; SALAZOSULFAPYRIDINE; SALICYLATE SODIUM; SULINDAC; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ATTENUATION; CACHEXIA; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE; CELL SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; METASTASIS; MOUSE; NONHUMAN; REGULATORY MECHANISM; REVIEW; SOLID TUMOR; DRUG RESISTANCE; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; GLUCOCORTICOIDS; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 0036327139     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP40336     Document Type: Review

References (108)

1. Proteasome inhibitors: A novel class of potent and effective antitumor agents
2. Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells
3. Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac
4. 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells
5. Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells
6. Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
7. Autocrine production of interleukin-1-beta confers constitutive NFκB activity and chemoresistance in pancreatic carcinoma cell lines
8. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
9. Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production by the introduction of a super-repressor form of inhibitor of nuclear factor kappaBalpha complementary DNA into gland acinar cells. Prevention of the destruction of the acinar structure in Sjögren's syndrome salivary glands
10. Induction of NF-kappa B DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts
11. Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways
12. Inhibitor of apoptosis-1 (IAP-1) expression and apoptosis in non-small-cell lung cancer cells exposed to gemcitabine
13. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
14. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
15. Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen receptor-negative breast cancer cells
16. NF-kappaB activation in response to toxical and therapeutical agents: Role in inflammation and cancer treatment
17. Mutations in the IκBα gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha
18. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
19. Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-kappaB inhibition
20. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell cycle-related proteins in rats
21. Selective activation of NF-kappa B subunits in human breast cancer: Potential roles for NF-kappa B2/p52 and for Bcl-3
22. Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-kappaB- and AP-1-dependent mechanism
23. Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation
24. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
25. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C
26. Glucocorticoid-mediated repression of nuclear factor kappaB-dependent transcription involves direct interference with transactivation
27. Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell
28. Combination chemotherapy in the treatment of Hodgkin's disease
29. Effects of food factors on signal transduction pathways
30. Inhibition of transcription factor nuclear factor-kappaB by a mutant inhibitor-kappaBalpha attenuates resistance of human head and neck squamous cell carcinoma to TNF-alpha caspase-mediated cell death
31. Treatment of advanced Hodgkin's lymphoma: Standard and experimental approaches
32. Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway
33. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: The role of reactive oxygen species
34. Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL
35. Inhibition of NF-kappa B activation in vitro and in vivo: Role of 26S proteasome
36. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
37. Nuclear factor kappaB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug
38. Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86 and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
39. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase
40. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
41. Nuclear factor-kappaB/IkappaB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells
42. p300/CBP-dependent and -independent transcriptional interference between NF-kappaB RelA and p53
43. Inhibition of anchorage-independent growth and lung metastasis of A549 lung carcinoma cells by IkappaBbeta
44. Inhibition of NF-kappaB sensitizes non-small cell lung cancer cells to chemotherapy-induced apoptosis
45. Evidence that de novo protein synthesis is dispensable for anti-apoptotic effects of NF-kappaB
46. Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators
47. The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus
48. How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex
49. Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice
50. Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
51. Sulindac causes regression of rectal polyps in familial adenomatous polyposis
52. The inhibitors of apoptosis (IAPs) and their emerging role in cancer
53. Antiproliferative effects of nitrosulindac on human colon adenocarcinoma cell lines
54. NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type
55. Nuclear factor-kappaB is upregulated in colorectal cancer
56. NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival
57. Nuclear factor-kappaB is constitutively active in C cell carcinoma and required for RET-induced transformation
58. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
59. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
60. Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling
61. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras
62. Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells
63. BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: A molecular and cytogenetic study
64. Antiproliferative effect of curcumin (diferuloyl-methane) against human breast tumor cell lines
65. The c-Jun-induced transformation process involves complex regulation of tenascin-C expression
66. Activation of nuclear factor-kappa B in human metastatic melanoma cells and the effect of oxidative stress
67. The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription
68. Effect of a mutant form of IkappaB-alpha on 5-fluorouracil-induced apoptosis in transformed human salivary gland cells
69. Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma
70. Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage
71. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
72. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50
73. Mechanistic aspects of green tea as a cancer preventive: Effect of components on human stomach cancer cell lines
74. Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells
75. Proteasome inhibitor-1 enhances paclitaxel-induced apoptosis in human lung adenocarcinoma cell line
76. Activators and target genes of Rel/NF-kappaB transcription factors
77. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
78. Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide
79. Inhibition of cyclooxygenase-2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex
80. Aberrant rel/nfkb genes and activity in human cancer
81. Biology of osteoclast activation in cancer
82. Role of NF-kappaB in p53-mediated programmed cell death
83. NF-kappaB/rel/IkappaB: Implications in gastrointestinal diseases
84. Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism
85. 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer
86. Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1
87. Aspirin-induced activation of the NF-kappaB signaling pathway: A novel mechanism for aspirin-mediated apoptosis in colon cancer cells
88. Nuclear factor (NF) kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
89. Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression
90. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
91. Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human non-small cell lung carcinoma
92. CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells
93. Towards a better aspirin
94. The 26S proteasome: A molecular machine designed for controlled proteolysis
95. Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
96. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
97. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
98. Activation of nuclear factor kappaB-dependent transcription by tumor necrosis factor alpha is mediated through phosphorylation of RelA/p65 on serine 529
99. The nuclear factor kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
100. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta
101. The role of cyclooxygenases in inflammation, cancer and development
102. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer
103. Sulindac inhibits activation of the NF-kappaB pathway
104. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
105. Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells
106. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation
107. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
108. NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death