The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

Nature Cell Biology

Volumn 4, Issue 7, 2002, Pages

  Hetzer, Martin ^a   Gruss, Oliver J ^a   Mattaj, Iain W ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; RAN PROTEIN; REGULATOR PROTEIN;

CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CHROMATIN; CHROMOSOME MARKER; CONTROLLED STUDY; CYTOPLASM; INTERPHASE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; GUANOSINE TRIPHOSPHATE; HUMANS; MITOTIC SPINDLE APPARATUS; NUCLEAR ENVELOPE; RAN GTP-BINDING PROTEIN;

EID: 0036306726     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb0702-e177     Document Type: Review

References (122)

1. Nucleocytoplasmic transport: The soluble phase
2. Transport between the cell nucleus and the cytoplasm
3. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation
4. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA
5. Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
6. Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1
7. RanGAP1 induces GTPase activity of nuclear Ras-related Ran
8. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
9. A giant nucleopore protein that binds Ran/TC4
10. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
11. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
12. Nucleocytoplasmic transport: Ran, beta and beyond
13. Dynamics of the endoplasmic reticulum and Golgi apparatus during early sea urchin development
14. The spindle: A dynamic assembly of microtubules and motors
15. Ran hits the ground running
16. Microtubule cytoskeleton: No longer an also Ran
17. Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly
18. The Ran GTPase regulates mitotic spindle assembly
19. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
20. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
21. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
22. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts
23. Ran binds to chromatin by two distinct mechanisms
24. Chromosomal association of Ran during meiotic and mitotic divisions
25. Ran induces spindle assembly by reversing the inhibitory effect of Importin α on TPX2 activity
26. Importin β is a mitotic target of the small GTPase Ran in spindle assembly
27. Role of Importin-β in coupling Ran to downstream targets in microtubule assembly
28. Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules
29. Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
30. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
31. TPX2, a novel Xenopus MAP involved in spindle pole organization
32. Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo
33. Premature of chromosome condensation in a ts DNA-mutant of BHK cells
34. NuMA is required for the proper completion of mitosis
35. Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export
36. The fission yeast ran GTPase is required for microtubule integrity
37. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo
38. Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
39. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities
40. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila
41. Integration of the centrosome in cell cycle control, stress response and signal transduction pathways
42. The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis
43. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans
44. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
45. Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes
46. Dynamics of the endoplasmic reticulum and Golgi apparatus during early sea urchin development
47. Nuclear envelope assembly after mitosis
48. Nuclear membrane dynamics
49. The nuclear envelope and the architecture of the nuclear periphery
50. The making and breaking of the endoplasmic reticulum
51. Inner nuclear membrane proteins: Functions and targeting
52. Nuclear lamins: Their structure, assembly, and interactions
53. Review: Nuclear lamins-structural proteins with fundamental functions
54. Functional organization of the nuclear envelope
55. An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region
56. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components
57. The nuclear pore complex
58. From nucleoporins to nuclear pore complexes
59. A tense time for the nuclear envelope
60. The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase
61. The regulation of mitotic nuclear envelope breakdown: A role for multiple lamin kinases
62. Cytoplasmic dynein as a facilitator of nuclear envelope breakdown
63. Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina
64. Remodeling the walls of the nucleus
65. Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes
66. A distinct vesicle population targets membranes and pore complexes to the nuclear envelope in Xenopus eggs
67. Distinct egg membrane vesicles differing in binding and fusion properties contribute to sea urchin male pronuclear envelopes formed in vitro
68. Temporal differences in the appearance of NEP-B78 and a LBR-like protein during Xenopus nuclear envelope reassembly reflect the order recruitment of functionally discrete vesicle types
69. In vitro nuclear assembly with affinity-purified nuclear precursor vesicle fractions, PV1 and PV2
70. Membrane-associated lamins in Xenopus egg extracts: Identification of two vesicle populations
71. Domain-specific disassembly and reassembly of nuclear membranes during mitosis
72. Sorting nuclear membrane proteins at mitosis
73. Nuclear membrane dynamics and reassembly in living cells: Targeting of an inner nuclear membrane protein in interphase and mitosis
74. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis
75. Golgi membranes are absorbed into and reemerge from the ER during mitosis
76. Membrane fusion events during nuclear envelope assembly
77. Nuclear assembly
78. Nuclear envelope assembly in Xenopus extracts visualized by scanning EM reveals a transport-dependent 'envelope smoothing' event
79. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly
80. Reconstituting the nuclear envelope and endoplasmic reticulum in vivo
81. Nuclear envelope dynamics during male pronuclear development
82. Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin
83. Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts
84. A trypsin-sensitive receptor on membrane vesicles is required for nuclear envelope formation in vitro
85. Characterization of the membrane binding and fusion events during nuclear envelope assembly using purified components
86. Nuclear pores and nuclear assembly
87. Assembly of the nuclear pore: Biochemically distinct steps revealed with NEM, GTPγS, and BAPTA
88. GTP hydrolysis is required for vesicle fusion during nuclear envelope assembly in vitro
89. Roles of cytosol and cytoplasmic particles in nuclear envelope assembly and sperm pronuclear formation in cell-free preparations from amphibian eggs
90. Functional role of newly formed pore complexes in postmitotic nuclear reorganization
91. A lamin-independent pathway for nuclear envelope assembly
92. Targeting of membranes to sea urchin sperm chromatin is mediated by a lamin B receptor-like integral membrane protein
93. Formation of the sea urchin male pronucleus in cell-free extracts
94. Spontaneous assembly of pore complex-containing membranes ('annulate lamellae') in Xenopus egg extract in the absence of chromatin
95. GTP hydrolysis by Ran is required for nuclear envelope assembly
96. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
97. Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system
98. Role of Importin-β in the control of nuclear envelope assembly by Ran
99. In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction
100. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells
101. The nuclear envelope: Filling in gaps
102. Roles of LAP2 proteins in nuclear assembly and DNA replication: Truncated LAP2β proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts
103. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
104. Rules to remodel by: What drives nuclear envelope disassembly and reassembly during mitosis?
105. The AAA team: Related ATPases with diverse functions
106. P47 is a cofactor for p97-mediated membrane fusion
107. Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum
108. Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro
109. The conserved np14 protein complex mediates proteasome-dependent membrane-bound transcription factor activation
110. Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone
111. A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways
112. Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
113. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
114. Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48
115. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene
116. Golgi structure correlates with transitional endoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae
117. Organelle membrane fusion: A novel function for the syntaxin homolog Ufe1p in ER membrane fusion
118. Role of the ubiquitin-selective CDC48(UFD1/NPL4) chaperone (segregase) in ERAD of OLE1 and other substrates
119. Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
120. The ran decathlon: Multiple roles of Ran
121. The Ran-GTPase and cell-cycle control