Nucleocytoplasmic transport: Ran, beta and beyond

Trends in Cell Biology

Volumn 11, Issue 12, 2001, Pages 497-503

  Kuersten, Scott ^a   Ohno, Mutsuhito ^a   Mattaj, Iain W ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; KARYOPHERIN; PROTEIN; RAN PROTEIN; RECEPTOR; RNA;

CELL FUNCTION; CELL NUCLEUS; CYTOPLASM; ENZYME ACTIVITY; INTRACELLULAR TRANSPORT; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR INTRINSIC ACTIVITY; REVIEW;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BETA KARYOPHERINS; CELL NUCLEUS; CHROMOSOMES; CYTOPLASM; HUMANS; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; RAN GTP-BINDING PROTEIN; RIBOSOMAL PROTEINS; RIBOSOMES; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 0035575518     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02144-4     Document Type: Review

References (62)

1. Pathways for the nuclear transport of proteins and RNAs
2. Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking
3. Nucleocytoplasmic transport: The last 200 nanometers
4. Nucleocytoplasmic transport: The soluble phase
5. Transport of proteins and RNA in and out of the nucleus
6. Transport between the cell nucleus and cytoplasm
7. New steps toward the nucleocytoplasmic traffic of macromolecules
8. Nucleocytoplasmic transport enters the atomic age
9. NPC translocation: Diffusion channel or phase transition?
10. The nuclear pore complex as a transport machine
11. Importin-β-like nuclear transport receptors
12. Nuclear pores and nuclear assembly
13. Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
14. Kinetic analysis of translocation through the nuclear pore complex
15. The yeast nuclear pore complex: Composition, architecture and transport mechanism
16. The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1
17. RanGTP-regulated interactions of CRM1 with nucleoporins and a DEAD-box helicase
18. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export
19. Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1
20. RanBP3 influences interactions between CRM1 and its nuclear export substrates
21. Ran-binding protein 3 is a co-factor for Crm1-mediated protein export
22. 3G-cap-specific nuclear import receptor with a novel domain structure
23. CRM1-mediated recycling of snurportin 1 to the cytoplasm
24. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
25. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p
26. Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for nuclear targeting
27. The karyopherin Kap142p/Msn5p mediates nuclear import and export of different cargo proteins
28. Regulation of nuclear localization: Key to the door
29. Importin-13: A novel mediator of nuclear import and export
30. A Ran-independent pathway for export of spliced mRNA
31. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
32. REF proteins mediate the export of both spliced and unspliced mRNAs from the nucleus
33. Splicing is required for rapid and efficient export in metazoans
34. The spliceosome deposits multiple proteins 22-24 nucleotides upstream of mRNA exon-exon junctions
35. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
36. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
37. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
38. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of the nuclear pore complex via a conserved interaction with CAN/Nup159p
39. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
40. The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr255p
41. An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B″ spliceosome proteins
42. The structure of the β-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by β-catenin
43. Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin
44. β-Catenin can be transported into the nucleus in a Ran-unassisted manner
45. Cytoplasmic transport of ribosomal subunits microinjected into the Xenopus laevis oocyte nucleus: A generalized, facilitated process
46. The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast
47. Nmd3p is a Crm1p-dependent adaptor protein for nuclear export of large ribosomal subunit
48. Nuclear export of 60S ribosomal subunits depends on Xpo1p and requires a nuclear export signal-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p
49. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
50. Maturation and intranuclear transport of pre-ribosomes requires the Noc proteins
51. Running on Ran: Nuclear transport and the mitotic spindle
52. Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?
53. GTP hydrolysis by Ran is required for nuclear envelope assembly
54. Chromatin-independent nuclear envelope assembly induced by RanGTPase in Xenopus egg extracts
55. Generation of GTP bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
56. The Ran GTPase regulates mitotic spindle assembly
57. Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX activity
58. Importin β is a mitotic target of the small GTPase Ran in spindle assembly
59. Role of importin-β in coupling Ran to downstream targets in microtubule assembly
60. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
61. NTF2 mediates nuclear import of Ran
62. Nuclear import of Ran is mediated by the transport factor NTF2