The conserved Np14 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

Molecular Biology of the Cell

Volumn 12, Issue 10, 2001, Pages 3226-3241

  Hitchcock, A L ^a   Krebber, H ^a   Frietze, S ^a   Lin, A ^a   Latterich, M ^a   Silver, P A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GREEN FLUORESCENT PROTEIN; PROTEASOME; RNA; TRANSCRIPTION FACTOR; ACYL COENZYME A DESATURASE; CDC48 PROTEIN; CELL CYCLE PROTEIN; CYSTEINE PROTEINASE; DELTA 9 FATTY ACID DESATURASE; DELTA-9 FATTY ACID DESATURASE; DNA BINDING PROTEIN; FUNGAL PROTEIN; MULTIENZYME COMPLEX; NPL4 PROTEIN, S CEREVISIAE; NUCLEAR PROTEIN; NUCLEOPORIN; PROTEIN; RPN4 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SPT23 PROTEIN, S CEREVISIAE; TRANSACTIVATOR PROTEIN; UFD1L PROTEIN, HUMAN;

ARTICLE; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; MEMBRANE BINDING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; YEAST; AMINO ACID SEQUENCE; ANIMAL; CAENORHABDITIS ELEGANS; CELL NUCLEUS MEMBRANE; DROSOPHILA; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN PROCESSING; ULTRASTRUCTURE;

SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CELL CYCLE PROTEINS; CONSERVED SEQUENCE; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; DROSOPHILA; ENDOPLASMIC RETICULUM; FATTY ACID DESATURASES; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; INTRACELLULAR MEMBRANES; MULTIENZYME COMPLEXES; MUTATION; NUCLEAR ENVELOPE; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; YEASTS;

EID: 0034746779     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.10.3226     Document Type: Article

References (69)

1. The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events
2. Fluorescence microscopy in three dimensions
3. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae
4. HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins
5. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
6. Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
7. A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast
8. Nutritional regulation of yeast delta-9 fatty acid desaturase activity
9. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
10. Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene
11. Multifunctional yeast high-copy-number shuttle vectors
12. Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha
13. Alzheimer's disease: Closing in on gamma-secretase
14. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene
15. Epitope-tagged ubiquitin: A new probe for analyzing ubiquitin function
16. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle
17. Analysis of polypeptide transit through yeast secretory pathway
18. Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression
19. Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae
20. Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin- mediated proteolysis in Saccharomyces cerevisiae
21. The regulatory particle of the Saccharomyces cerevisiae proteasome
22. The Janus face of the archaeal Cdc48/p97 homologue VAT: Protein folding versus unfolding
23. Fatty acid-responsive control of mRNA stability: Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript
24. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
25. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy
26. The ubiquitin system
27. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
28. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
29. A proteolytic pathway that recognizes ubiquitin as a degradation signal
30. The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B
31. Use of the A. Victoria green fluorescent protein to study protein dynamics in vivo
32. Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast
33. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
34. Genome-wide transposon mutagenesis in yeast
35. Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
36. The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
37. Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast
38. A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways
39. Cold-sensitive cell-division-cycle mutants of yeast: Isolation, properties, and pseudoreversion studies
40. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain
41. Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae
42. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control
43. The AAA team: Related ATPases with diverse functions
44. Probability-based protein identification by searching sequence databases using mass spectrometry data
45. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
46. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
47. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments
48. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
49. A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors
50. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
51. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells
52. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
53. Affinity purification of protein A-tagged nuclear pore proteins from yeast
54. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
55. Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae
56. The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene
57. Proteolysis and the cell cycle: With this RING I do thee destroy
58. The 26S proteasome: A molecular machine designed for controlled proteolysis
59. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
60. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
61. Internal protein sequencing of SDS-PAGE separated proteins: Optimization of an in-gel digest protocol
62. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C
63. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
64. Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
65. Genetic redundancy between SPT23 and MGA2: Regulators of Ty-induced mutations and Ty1 transcription in Saccharomyces cerevisiae
66. MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae
67. The engagement of Sec61p in the ER dislocation process