Integration of the centrosome in cell cycle control, stress response and signal transduction pathways

Current Opinion in Cell Biology

Volumn 14, Issue 1, 2002, Pages 35-43

  Lange, Bodo M H ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA TUBULIN; M PROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; REGULATOR PROTEIN;

CANCER; CELL ACTIVITY; CELL COMPOSITION; CELL CYCLE; CELL FUNCTION; CELL INTERACTION; CELL MATURATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CENTROSOME; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRESS;

EID: 0036468701     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(01)00291-5     Document Type: Review

References (74)

1. How centrioles work: Lessons from green yeast
2. Basal bodies and centrioles: Their function and structure
3. Delta-tubulin and epsilon-tubulin: Two new human centrosomal tubulins reveal new aspects of centrosome structure and function
4. Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: The role of ninein
5. The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells
6. A novel 95-kD protein is located in a linker between cytoplasmic microtubules and basal bodies in a green flagellate and forms striated filaments in vitro
7. Studying the composition and function of centrosomes in vertebrates
8. Molecular characteristics of the centrosome
9. Re-evaluating centrosome function
10. Spindle pole body duplication: A model for centrosome duplication?
11. Centrioles take center stage
12. The disassembly and reassembly of functional centrosomes in vitro
13. Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds
14. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: Its identification from isolated centrosomes
15. Gamma-tubulin complexes: Binding to the centrosome, regulation and microtubule nucleation
16. Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits
17. The role of Xgrip210 in gamma-tubulin ring complex assembly and centrosome recruitment
18. Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization
19. Regulating centrosomes by protein phosphorylation
20. AKAP signaling complexes at the cytoskeleton
21. Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain
22. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
23. The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin
24. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes
25. 'It takes two to tango': Understanding how centrosome duplication is regulated throughout the cell cycle
26. Centrosome duplication. A centriolar pas de deux
27. The mouse Mps1p-like kinase regulates centrosome duplication
28. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication
29. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication
30. The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo
31. Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro
32. Centrosome organization and centriole architecture: Their sensitivity to divalent cations
33. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
34. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
35. The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila
36. The centrosome-associated Aurora/Ipl-like kinase family
37. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
38. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
39. The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion
40. NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1
41. Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication
42. Centrosome maturation
43. Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase
44. Metaphase arrest with centromere separation in polo mutants of Drosophila
45. Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes
46. Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos
47. Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
48. The centrosome in vertebrates: More than a microtubule-organizing center
49. The Bub2p spindle checkpoint links nuclear migration with mitotic exit
50. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome
51. Centrosome-dependent exit of cytokinesis in animal cells
52. Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression
53. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase
54. Conditional mutations in gamma-tubulin reveal its involvement in chromosome segregation and cytokinesis
55. The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint
56. Integrating stress-response and cell-cycle checkpoint pathways
57. DNA replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos
58. Polo-like kinase-1 is a target of the DNA damage checkpoint
59. Structural alterations of the mitotic apparatus induced by the heat shock response in Drosophila cells
60. Molecular chaperones and the cytoskeleton
61. Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates
62. Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability
63. Hsp90: A specialized but essential protein-folding tool
64. Chfr defines a mitotic stress checkpoint that delays entry into metaphase
65. Vaccinia virus infection disrupts microtubule organization and centrosome function
66. The role of the centrosome in the development of malignant tumors
67. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway
68. The role of p53 in the response to mitotic spindle damage
69. Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour
70. D-TACC: A novel centrosomal protein required for normal spindle function in the early Drosophila embryo
71. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression
72. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry
73. Centrosome cohesion is regulated by a balance of kinase and phosphatase activities