A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

EMBO Journal

Volumn 19, Issue 10, 2000, Pages 2181-2192

  Meyer, Hemmo H ^a   Shorter, James G ^a   Seemann, Joachim ^a   Pappin, Darryl ^b   Warren, Graham ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

AAA ATPase; CDC48; DiGeorge; Ubiquitin; UFD1L

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CELL PROTEIN; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; COMPLEX FORMATION; GOLGI COMPLEX; LIVER CYTOSOL; MEMBRANE FUSION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; RAT;

ANIMALIA; MAMMALIA;

EID: 0034658270     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.10.2181     Document Type: Article

References (47)

1. Acharya, U., Jacobs, R., Peters, J.-U., Watson, N., Farquhar, M.G. and Malhotra, V. (1995) The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events. Cell, 82, 895-904.
2. Baldini, A. (1999) Is the genetic basis of DiGeorge syndrome in HAND? Nature Genet., 21, 246-247.
3. Bleasby, A.J. and Wootton, J.C. (1990) Construction of validated, non-redundant composite protein sequence databases. Protein Eng., 3, 153-159.
4. Coles, M., Diercks, T., Liermann, J., Groger, A., Rockel, B., Baumeister, W., Koretke, K.K., Lupas, A., Peters, J. and Kessler, H. (1999) The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple βαββ element. Curr. Biol., 9, 1158-1168.
5. Dai, R., Chen, E., Longo, D., Gorbea, C. and Li, C. (1998) Involvement of valosin-containing protein, an ATPase co-purified with IκBα and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IκBα. J. Biol. Chem., 273, 3562-3573.
6. DeHoratius, C. and Silver, P.A. (1996) Nuclear transport defects and nuclear envelope alterations arc associated with mutation of the Saccharomyces cerevisiae NPL4 gene. Mol. Biol. Cell, 7, 1835-1855.
7. del Olmo, M., Mizrahi, N., Gross, S. and Moore, C.L. (1997) The Uba2 and Ufd1 proteins of Saccharomyces cerevisiae interact with poly(A) polymerase and affect the polyadenylation activity of cell extracts. Mol. Gen. Genet., 255, 209-218.
8. Fröhlich, K.-U., Fries, H.-W., Rudiger, M., Erdmann, R., Botstein, D. and Mecke, D. (1991) Yeast cell cycle protein cdc48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation and gene expression. J. Cell Biol., 114, 443-453.
9. Ghislain, M., Dohmen, R., Levy, F. and Varshavsky, A. (1996) Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cereviae. EMBO J., 15, 4884-4899.
10. Golbik, R., Lupas, A., Koretke, K., Baumeister, W. and Peters, J. (1999) The Janus face of the archaeal Cdc48/p97 homologue VAT: protein folding versus unfolding. Biol. Chem., 380, 1049-1062.
11. Hanson, P.I., Roth, R., Morisaki, H., Jahn, R. and Heuser, J.E. (1997) Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell, 90, 523-535.
12. Harlow, E. and Lane, D. (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor Laboratory, NY.
13. Hoss, M., Robins, P., Naven, T.J.P., Pappin, D.J.C, Sgouros, J. and Lindahl, T. (1999) A human DNA editing enzyme homologous to the Escherichia coli DNaQ/MutD protein. EMBO J., 18, 3868-3875.
14. Hui, N., Nakamura, N., Slusarewicz, P. and Warren, G. (1998) Purification of rat liver Golgi stacks. In Celis, J. (ed.). Cell Biology. A Laboratory Handbook. Academic Press, San Diego, CA, Vol. 2, pp. 46-55.
15. Hunt, D.F., Yates, J.R., Shabanowitz, J., Winston, S. and Hauer, C.R. (1986) Protein sequencing by tandem mass spectrometry. Proc. Natl Acad. Sci. USA, 84, 6233-6237.
16. Johnson, E.S., Ma, P.C., Ota I.M. and Varshavsky, A. (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem., 270, 17442-17456.
17. Johnson, E.S., Schwienhorst, I., Dohmen, R.J. and Blobel, G. (1997) The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J., 16, 5509-5519.
18. Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H., Mayer, T. and Jentsch, S. (1999) A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell, 96, 635-644.
19. Koller, K. and Brownstein, M. (1987) Use of a cDNA clone to identify a supposed precursor containing valosin. Nature, 325, 542-545.
20. Kondo, H., Rabouille, C., Newman, R., Levine, T.P., Pappin, D., Freemont, P. and Warren, G. (1997) p47 is a cofactor for p97-mediated membrane fusion. Nature. 388, 75-78.
21. Latterich, M., Fröhlich, K.-U. and Schekman, R. (1995) Membrane fusion and the cell cycle: cdc48p participates in the fusion of ER membranes. Cell, 82, 885-893.
22. Lindsay, E., Botta, A., Jurecic, V., Carattini-Rivera, S., Cheah, Y., Rosenblatt, H., Bradley, A. and Baldini, A. (1999) Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature, 401, 379-383.
23. Madeo, F., Schlauer, J., Zischka, H., Mecke, D. and Fröhlich, K. (1998) Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p. Mol. Biol. Cell, 9, 131-141.
24. Mahajan, R., Delphin, C., Guan, T., Gerace, L. and Melchior, F. (1997) A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell, 88, 97-107.
25. Matunis, M.J., Wu, J. and Blobel, G. (1998) SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J. Cell Biol., 140, 499-509.
26. Moir, D., Stewart, S., Osmond, B. and Botstein, D. (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties and pseudoreversion studies. Genetics, 100, 547-563.
27. Müller, J.M.M., Meyer, H.H., Ruhrberg, C., Stamp, G.W., Warren, G. and Shima, D.T. (1999) The mouse p97 (CDC48) gene: genomic structure, definition of transcriptional regulatory sequences, gene expression and characterization of a pseudogene. J. Biol. Chem., 274, 10154-10162.
28. Nakielny, S., Shaikh, S., Burke, B. and Dreyfuss, G. (1999) Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J., 18, 1982-1995.
29. Pamnani, V., Tamura, T., Lupas, A., Peters, J., Cejka, Z., Ashraf, W. and Baumeister, W. (1997) Cloning, sequencing and expression of VAT, a CDC48/p97 ATPase homologue from the archaeon Thermoplasma acidophilum. FEBS Lett., 404, 263-268.
30. Patel, S. and Latterich, M. (1998) The AAA team: related ATPases with diverse functions. Trends Cell Biol., 8, 65-71.
31. Perkins, D.N., Pappin, D.J., Creasey, D.M. and Cottrell, J.S. (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis, 20, 3551-3567.
32. Peters, J.-M., Walsh, M.J. and Franke, W.W. (1990) An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins. Sec18p and NSF. EMBO J., 9, 1757-1767.
33. 2+-ATPase complex: a structural study. J. Mol. Biol., 223, 557-571.
34. Pizzuti, A., Novelli, G., Ratti, A., Amati, F., Mari, A., Calabrese, G., Nicolis, S., Silvani, V., Marino, B., Scarlato, G., Ottolenghi, S. and Dallapiccola, B. (1997) UFDIL, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome. Hum. Mol. Genet., 6, 259-265.
35. Rabouille, C., Levine, T.P., Peters, J.M. and Warren, G. (1995a) An NSF-like ATPase, p97 and NSF mediate cisternal regrowth from mitotic Golgi fragments. Cell, 82, 905-914.
36. Rabouille, C., Misteli, T., Watson, R. and Warren, G. (1995b) Reassembly of Golgi stacks from mitotic Golgi Fragments in a cell-free system. J. Cell Biol. 129, 605-618.
37. Rabouille, C., Kondo, H., Newman, R., Hui, N., Freemont, P. and Warren, G. (1998) Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of the Golgi cisternae from mitotic Golgi fragments in vitro. Cell, 92, 603-610.
38. Schinke, M. and Izumo, S. (1999) Getting to the heart of DiGeorge syndrome. Nature Med., 5, 1120-1121.
39. Sherman, N.E., Yates, N.A., Shabanowitz, J., Hunt, D.F., Jeffery, W.A., Barllet-Jones, M. and Pappin, D.J.C. (1995) A novel N-terminal derivative designed to simplify peptide fragmentation. 43rd ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, GA, pp. 626-627.
40. Shevchenko, A., Wilm, M., Vorm, O. and Mann, M. (1996) Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal. Chem., 68, 850-858.
41. Shorter, J. and Warren, G. (1999) A role for the vesicle tethering protein, p115, in the post-mitotic stacking of reassembling Golgi cisternae in a cell-free system. J. Cell Biol., 146, 57-70.
42. Söllner, T., Bennett, M.K., Whiteheart, S.W., Scheller, R. H. and Rothman, J.E. (1993) A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation and fusion. Cell, 15, 409-418.
43. Whiteheart, S.W., Rossnagel, K., Buhrow, S.A., Brunner, M., Jaenicke, R. and Rothman, J.E. (1994) N-ethylmaleimide-sensitive fusion protein -a trimeric ATPase whose hydrolysis of ATP is required for membrane-fusion. J. Cell Biol., 126, 945-954.
44. Wilm, M. and Mann, M. (1996) Analytical properties of the Nanoeleotrospray ion source. Anal. Chem., 68, 1-8.
45. Xu, Z., Horwich, A.L. and Sigler, P.B. (1997) The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. Nature, 388, 741-750.
46. Yamagishi, H., Garg, V., Matsuoka, R., Thomas, T. and Srivastava, D. (1999) A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science, 283, 1158-1161.
47. Yaseen, N.R. and Blobel, G. (1999) Two distinct classes of Ran-binding sites on the nucleoporin Nup-358. Proc. Natl Acad. Sci. USA, 96, 5516-5521.