Inner nuclear membrane proteins: Functions and targeting

Cellular and Molecular Life Sciences

Volumn 58, Issue 12-13, 2001, Pages 1741-1747

  Holmer, L ^a   Worman, H J ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

Dunnigan type partial lipodystrophy; Emery Dreifuss muscular dystrophy; Intracellular protein trafficking; Lamin B receptor; Lamina associated polypepfide; Limb girdle muscular dystrophy; Nuclear envelope; Nuclear lamina; Nurim

Indexed keywords

EMERIN; LAMIN; LAMIN B; LAMIN B RECEPTOR; LAMINA ASSOCIATED POLYPEPTIDE 1; LAMINA ASSOCIATED POLYPEPTIDE 2; NUCLEAR PROTEIN; PROTEIN NURIM; UNCLASSIFIED DRUG;

CELL NUCLEUS MEMBRANE; CHROMATIN; ENDOPLASMIC RETICULUM; GENE CONTROL; GENE MUTATION; HUMAN; LIPODYSTROPHY; MOLECULAR DYNAMICS; MUSCULAR DYSTROPHY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; STEROL METABOLISM;

EID: 0035197416     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000813     Document Type: Review

References (71)

1. The inner nuclear membrane
2. A lamin B receptor in the nuclear envelope
3. The lamin B receptor of the nuclear envelope inner membrane: A polytopic protein with eight potential transmembrane domains
4. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane
5. Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane
6. The human lamin B receptor/sterol reductase multigene family
7. Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1 and LBR by fluorescence in situ hybridization
8. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR
9. Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker
10. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1
11. Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR
12. Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster
13. The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation
14. Gene gating: A hypothesis
15. Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery
16. LBR, a chromatin and lamin binding protein from the inner nuclear membrane, is proteolyzed at late stages of apoptosis
17. Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
18. The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase
19. Increased phosphorylation of HP1, a heterochromatin-associated protein of Drosophila, is correlated with heterochromatin assembly
20. Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae
21. The erg-3 (sterol delta14,15-reductase) gene of Neurospora crassa: Generation of null mutants by repeat-induced point mutation and complementation by proteins chimeric for human lamin B receptor sequences
22. Integral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina
23. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
24. cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane
25. Internuclear exchange of an inner nuclear membrane protein (p55) in heterokaryons: In vivo evidence for the interaction of p55 with the nuclear lamina
26. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2
27. Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope
28. Functional diversity of LAP2α and LAP2β in postmitotic chromosome association is caused by an α-specific nuclear targeting domain
29. The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain
30. The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products
31. Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin
32. Characterization of the chromatin binding activity of lamina-associated polypeptide (LAP) 2
33. Roles of LAP2 proteins in nuclear assembly and DNA replication: Truncated LAP2β proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts
34. Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase
35. Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy
36. Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy
37. The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein
38. The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membrane
39. Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
40. Direct interaction between emerin and lamin A
41. Distribution of emerin during the cell cycle
42. Live fluorescence imaging reveals early recruitment of emerin, LBR, RanBP2, and Nup 153 to reforming functional nuclear envelopes
43. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
44. Emery-Dreifuss muscular dystrophy-a 40 year retrospective
45. The Emery-Dreifuss muscular dystrophy mutation database
46. Mutations in Emery-Dreifuss muscular dystrophy and their effects on emerin protein expression
47. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy
48. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)
49. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease
50. Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement
51. Clinical and molecular genetic spectrum of antosomal dominant Emery-Dreifuss muscular dystrophy due to mutations of the lamin A/C gene
52. Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial parrial lipodystrophy
53. Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C
54. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
55. Insertional mutation of the Drosophila nuclear lamin Dm0 gene results in defective nuclear envelopes, clustering of nuclear pore complexes, and accumulation of annulate lamellae
56. Ultrastructural abnormality of sarcolemmal nuclei in Emery-Dreifuss muscular dystrophy (EDMD)
57. Nuclear changes in apoptosis
58. A visual screen ofa GFP-fusion library identifies a new type of nuclear envelope membrane protein
59. MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin
60. The MAN antigens are non-lamin constituents of the nuclear lamina in vertebrate cells
61. Molecular characterization and developmentally regulated expression of Xenopus lamina-associated polypeptide 2 (XLAP2)
62. C. elegans nuclear envelope proteins emerin, MAN1, lamin and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis
63. LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction
64. Intracellular protein topogenesis
65. Architecture and design of the nuclear pore complex
66. The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal
67. Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane
68. Nuclear membrane dynamics and reassembly in living cells: Targeting of an inner nuclear membrane protein in interphase and mitosis
69. The first membrane spanning region of the lamin B receptor is sufficient for sorting to the inner nuclear membrane
70. Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein
71. Distinct regions specify the nuclear membrane targeting of emerin, the responsible protein for Emery-Dreifuss muscular dystrophy