The GTpase Ran regulates chromosome positioning and nuclear envelope assembly in vivo

Current Biology

Volumn 12, Issue 6, 2002, Pages 503-507

  Bamba, Chisa ^a   Bobinnec, Yves ^a   Fukuda, Makoto ^a   Nishida, Eisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; CELL CYCLE PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; NUCLEAR PROTEIN; RAN 3 PROTEIN, C ELEGANS; RAN PROTEIN; RAN-3 PROTEIN, C ELEGANS; RANGAP PROTEIN, C ELEGANS;

ANIMAL; ANIMAL EMBRYO; ARTICLE; CAENORHABDITIS ELEGANS; CELL NUCLEUS; CHROMOSOME; GENETICS; INTRACELLULAR MEMBRANE; METABOLISM; MUTATION; PRENATAL DEVELOPMENT;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL CYCLE PROTEINS; CELL NUCLEUS; CHROMOSOMES; EMBRYO, NONMAMMALIAN; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INTRACELLULAR MEMBRANES; MUTATION; NUCLEAR PROTEINS; RAN GTP-BINDING PROTEIN;

EID: 0036006303     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00741-8     Document Type: Article

References (24)

1. Nucleocytoplasmic transport: The soluble phase
2. Transport between the cell nucleus and the cytoplasm
3. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
4. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
5. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
6. Ran-GTP stabilizes microtubule asters and inhibits nuclear assembly in Xenopus egg extracts
7. The Ran GTPase regulates mitotic spindle assembly
8. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
9. GTP hydrolysis by Ran is required for nuclear envelope assembly
10. The roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell free system
11. Role of importin-β in coupling Ran to downstream targets in microtubule assembly
12. Importin β is a mitotic target of the small GTPase Ran in spindle assembly
13. Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX2 activity
14. Genome sequence of the nematode C. elegans: A platform for investigating biology
15. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
16. Potent and specific genetic interference by double-stranded RNA in Caenorhabdites elegans
17. Specific interference by ingested dsRNA
18. Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues
19. Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
20. Functional analysis of kinetochore assembly in Caenorhabditis elegans
21. Ran/TC4: A small nuclear GTP-binding protein that regulates DNA synthesis
22. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement
23. Xkid, a chromokinesin required for chromosome alignment on the metaphase plate
24. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities