Expansion and length-dependent fragility of CTG repeats in yeast

Science

Volumn 279, Issue 5352, 1998, Pages 853-856

  Freudenreich, Catherine H ^a   Kantrow, Sara M ^a   Zakian, Virginia A ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYUREA; NUCLEASE; TRINUCLEOTIDE;

ARTICLE; CHROMATIN STRUCTURE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILITY; CONTROLLED STUDY; DNA REPLICATION; GENETIC DISORDER; GENETIC RECOMBINATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRINUCLEOTIDE REPEAT;

CHROMOSOME BREAKAGE; CHROMOSOME FRAGILITY; CHROMOSOMES, FUNGAL; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA, FUNGAL; ELECTROPHORESIS, GEL, PULSED-FIELD; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; GENE DELETION; GENES, FUNGAL; HUMANS; HYDROXYUREA; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; TRANSFORMATION, GENETIC; TRINUCLEOTIDE REPEAT EXPANSION; TRINUCLEOTIDE REPEATS;

SACCHAROMYCES CEREVISIAE;

EID: 0032488872     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5352.853     Document Type: Article

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41. We thank R. Kolodner for his suggestion that we analyze CTG tracts in a rad27Δ strain; R. Wellinger and J. Stavenhagen for sharing unpublished data; and J. Haber, T. Vogt, L. Sandell, V. Schulz, and members of the Zakian lab for helpful comments. Supported by NIH grants GM26938 and GM43265. C.H.F. was supported by NIH postdoctoral fellowship AG05740-02 and S.M.K. by a grant from the New Jersey State Cancer Commission.