Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Δ with other DNA repair genes in Saccharomyces cerevisiae

Genetics

Volumn 157, Issue 2, 2001, Pages 557-565

  Klein, Hannah L ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA REPAIR PROTEIN RAD; HELICASE; PROTEIN; REPRESSOR PROTEIN; REPRESSOR PROTEIN SRS2; UNCLASSIFIED DRUG;

ARTICLE; DNA REPAIR; GENE MUTATION; GENE REPRESSION; GENETIC RECOMBINATION; LETHAL MUTANT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CHROMOSOMES; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; GENOTYPE; MUTATION; PHENOTYPE; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUPPRESSION, GENETIC;

SACCHAROMYCES CEREVISIAE;

EID: 0035108094     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

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2. Semidominant suppressors of Srs2 helicase mutations of Saccharomyes cerevisiae map in the RAD15 gene, whose sequence predicts a protein with similarities to procryotic RecA proteins
3. A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae
4. Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae
5. Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase
6. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
7. Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1
8. Evolution of the SNF2 family of proteins: Subfamilies with distinct sequences and functions
9. Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro
10. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
11. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
12. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
13. The many interfaces of Mre11
14. Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: Implications for nucleotide excision repair
15. Regulation of the Saccharomyces cerevisiae Srs2 helicase during the mitotic cell cycle, meiosis and after irradiation
16. RAD1 and RAD1O, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae
17. The complexity of the interaction between RAD52 and SRS2
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20. Different types of recombination events are controlled by the RAD1 and RAD52 genes of Saccharomyces cerevisiae
21. RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis
22. Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants
23. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
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25. Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity
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32. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins
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34. Multiple pathways for homologous recombination in Saccharomyces cerevisiae
35. Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene
36. Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
37. The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
38. Genetic control of diploid recover, after gamma-irradiation in the yeast Saccharomyes cerevisiae
39. RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination
40. Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity
41. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
42. Characterization of the roles of the Saccharomyes cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis
43. Evidence that the Rad1 and Rad10 proteins of Saccharomyces cerevisiae participate as a complex in nucleotide excision repair of UV radiation damage
44. Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5′- to 3′-exonuclease required for lagging strand DNA synthesis in reconstituted systems
45. Homologous recombination is required for the viability of rad27 mutants
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47. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
48. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
49. Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease
50. Mutations in RAD27 define a potential link between G1 cyclins and DNA replication
51. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
52. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
53. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases