Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells

Cancer Research

Volumn 58, Issue 11, 1998, Pages 2316-2322

  Yamazaki, Vikky ^a   Wegner, Rolf Dieter ^b   Kirchgessner, Cordula U ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ARTICLE; ATAXIA TELANGIECTASIA; CANCER SUSCEPTIBILITY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IONIZING RADIATION; NIJMEGEN BREAKAGE SYNDROME; PRIORITY JOURNAL; RADIOSENSITIVITY;

EID: 0032101583     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Weemaes, C. M., Hustinx, T. W., Scheres, J. M., Van Munster, P. J., Bakkeren, J. A., and Taalman, R. D. A new chromosomal instability disorder: the Nijmegen breakage syndrome. Acta Paediatr. Scand., 70: 557-564, 1981.
2. Lavin, M. F., and Shiloh, Y. The genetic defect in ataxia-telangiectasia. Annu. Rev. Immunol., 15: 177-202, 1997.
3. Weemaes, C. M., Smeets, D. F., and Van der Bürgt, C. J. Nijmegen Breakage syndrome: a progress report. Int. J. Radiat. Biol., 66: S185-S188, 1994.
4. Seemanová, E. An increased risk for malignant neoplasms in heterozygotes for a syndrome of microcephaly, normal intelligence, growth retardation, remarkable facies, immunodeficiency and chromosomal instability. Mutat. Res., 238: 321-324, 1990.
5. Savitsky, K. A., Bar-Shira, S., Gilard, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Friydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chess, L., and Sanal, O. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (Washington DC), 268: 1749-1753, 1995.
6. Stumm, M., Gatti, R. A., Reis, A., Udar, N., Chrzanowska, K., Seemanová, E., Sperling. K., and Wegner, R.-D. The ataxia-telangiectasia-variant genes 1 and 2 are distinct from the atuxia-telangiectasia gene on chromosome 11q23.1. Am. J. Hum. Genet., 57: 960-962, 1995.
7. Komatsu, K., Matsuura, S., Tauchi, H., Endo, S., Kodama, S., Smeets, D., Weemaes, C., and Oshimura, M. The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11. Am. J. Hum. Genet., 58: 885-888, 1996.
8. Matsuura, S., Weemaes, C., Smeets, D., Takami, H., Kondo, N., Sakamoto, S., Yano, N., Nakamura, A., Tauchi, H., Endo, S., Oshimura, M., and Komatsu, K. Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24. Am. J. Hum. Genet., 60: 1487-1494, 1997.
9. Saar, K., Chrzanowska, K. H., Stumm, M., Jung, M., Nürnberg, G., Wienker, T. F., Seemanová, E., Wegner, R.-D., Reis, A., and Sperling, K. The gene for the ataxiatelangiectasia variant. Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21. Am. J. Hum. Genet., 60: 605-610, 1997.
10. Westphal, C. H. Cell-cycle signaling: Atm displays its many talents. Curr. Biol., 7: R789-R792, 1997.
11. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71: 587-597, 1992.
12. 1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res., 54: 5054-5058, 1994.
13. Rudolph, N. S., and Latt, S.A. Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia. Mutat. Res., 211: 31-41, 1989.
14. Beamish, H., Williams, R., Chen, P., and Lavin, M. F. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J. Biol. Chem., 271: 20486-20493, 1996.
15. Conley, M. E., Spinner, N. B., Emanuel, B. S., Nowell, P. C. and Nichols, W. W. A chromosomal breakage syndrome with profound immunodeficiency. Blood, 67: 1251-1256, 1986.
16. Jaspers, N. G., Taalman, R. D. F. M., and Baan, C. Patients with an inherited syndrome characterized by immunodeficiency, microcephaly, and chromosomal instability: genetic relationship to ataxia telangiectasia. Am. J. Hum. Genet., 42: 66-73, 1988.
17. Der Kaloustian, V. M., Kleijer, W., Booth, A., Auerbach, A. D., Mazer, B., Elliott, A. M., Abish, S., Usher, R., Watters, G., Vekemans, M., and Eydoux, P. Possible new variant of Nijmegen breakage syndrome. Am. J. Med. Genet., 65: 21-26, 1996.
18. Wegner, R.-D. Chromosomal instability syndromes in man. In: G. Obe (ed.), Advances in Mutagensis Research, pp. 105-106. Berlin: Springer-Verlag, 1991.
19. Nove, J., Little, J. B., Mayer, P. J., Troilo, P., and Nichols, W. W. Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents. Mutat. Res., 163: 255-262, 1986.
20. Lu, X., and Lane, D. P. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell, 75: 765-778, 1993.
21. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell, 75: 495-505, 1993.
22. Antoccia, A., Ricordy, R., Maraschio, P., Prudente, S., and Tanzarella, C. Chromosomal sensitivity to clastogenic agents and cell cycle perturbations in Nijmegen breakage syndrome lymphoblastoid cell lines. Int. J. Radiat. Biol., 71: 41-49, 1997.
23. Jongmans, W., Vuillaume, M., Chrzanowska, K., Smeets, D., Sperling, K., and Hall, J. Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol. Cell. Biol., 17: 5016-5022, 1997.
24. Sullivan, K. E., Veksler, E., Lederman, H., and Lees-Miller, S. P. Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. Clin. Immunol. Immunopathol., 82: 43-48, 1997.
25. Tupler, R., Marseglia, G. L., Stefanini, M., Prosperi, E., Chessa, L., Nardo, T., Marchi, A., and Maraschio, P. A variant of the Nijmegen breakage syndrome with unusual cytogenetic features and intermediate cellular radiosensitivity. J. Med. Genet., 34: 196-202, 1997.
26. Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E., and Givol, D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res., 54: 3391-3395, 1994.
27. 1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol., 14: 6264-6277, 1994.
28. Hartwell, L. H., and Kastan, M. B. Cell cycle control and cancer. Science (Washington DC), 266: 1821-1828, 1994.
29. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
30. Wang, L., Cui, Y., Lord, B. I., Roberts, S. A., Potten, C. S., Hendry, J. H., and Scott, D. γ-Ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice. Mutat. Res., 146: 259-266, 1996.
31. Almasan, A., Linke, S. P., Paulson, T. G., Huang, L. C., and Wahl, G. M. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metast. Rev., 14: 59-73, 1995.
32. Cornforth, M. N., and Bedford, J. S. On the nature of a defect in cells from individuals with ataxia-telangiectasia. Science (Washington DC), 227: 1589-1591, 1985.
33. Morgan, S. E., Lovly, C., Pandita, T. K., Shiloh, Y., and Kastan, M. B. Fragments of ATM which have dominant-negative or complementing activity. Mol. Cell. Biol., 17: 2020-2029, 1997.