Amyloid β-peptide induces cholinergic dysfunction and cognitive deficits: A minireview

Peptides

Volumn 23, Issue 7, 2002, Pages 1271-1283

  Tran, Manh Hung ^a   Yamada, Kiyofumi ^a   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholine; Alzheimer's disease; Amyloid peptide; Learning and memory; Nicotinic acetylcholine receptor; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-28]; AMYLOID BETA PROTEIN[1-34]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[12-28]; AMYLOID BETA PROTEIN[16-20]; AMYLOID BETA PROTEIN[18-20]; AMYLOID BETA PROTEIN[25-35]; AMYLOID BETA PROTEIN[31-34]; AMYLOID PRECURSOR PROTEIN; CHOLINE ACETYLTRANSFERASE; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG; CHOLINERGIC RECEPTOR;

ALZHEIMER DISEASE; AMNESIA; ARTICLE; BRAIN DYSFUNCTION; CHOLINERGIC SYSTEM; COGNITIVE DEFECT; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; LEARNING DISORDER; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SYNTHESIS; AMINO ACID SEQUENCE; ANIMAL; AUTONOMIC NEUROPATHY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; FORECASTING; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; CHOLINE O-ACETYLTRANSFERASE; COGNITION DISORDERS; FORECASTING; HUMANS; KINETICS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CHOLINERGIC;

EID: 0036075848     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00062-1     Document Type: Review

References (140)

1. Administration of amyloid β-peptides into the medium septum of rats decreases acetylcholine release from hippocampus in vivo
2. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism
3. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta-, Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent
4. Properties of neuronal nicotinic acetylcholine receptors: Pharmacological characterization and modulation of synaptic function
5. Defined neurofilament, tau and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques
6. Beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices
7. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein (A beta P-(1-40)) in bilayer membranes
8. Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: Blockade by tromethamine
9. Biogenic amines, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata
10. Peroxynitrite versus hydroxyl radical: The role of nitric oxide in superoxide-dependent cerebral injury
11. Nitric oxide, superoxide, and peroxynitrite: The good, the bad
12. Vitamin E protects nerve cells from amyloid β-protein toxicity
13. Hydrogen peroxide mediates amyloid β protein toxicity
14. Fresh and globular amyloid β protein (1-42) induces rapid cellular degeneration: Evidence for Aβ-protein channel-mediated cellular toxicity
15. Biochemical studies of nerve cells and energy metabolism in Alzheimer's disease
16. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
17. 2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation
18. Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type
19. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides
20. The neurochemical and behavioral effects of β-amyloid peptide (25-35)
21. + channel openers on beta-amyloid induced cerebrovascular endothelial dysfunction
22. Role of potassium channels in amyloid-induced cell death
23. Alzheimer's disease: A disorder of central cholinergic innervation
24. Serotonin in Alzheimer-type dementia
25. Neurotransmitter receptors, Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression
26. Beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus
27. Peroxynitrite induces tryosine nitration
28. Alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein
29. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils
30. + channels
31. Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease
32. Amnestic effects in mice of four synthetic peptides homologous to amyloid β protein from patients with Alzheimer's disease
33. Topography of a binding site for small amnestic peptides deduced from structure-activity studies: Relation to amnestic effect of amyloid β protein
34. Antemortem measurements of neurotransmission: Possible implications for pharmacotherapy of Alzheimer's disease and depression
35. Alpha-MSH peptides inhibit production of nitric oxide and tumor necrosis factor-alpha by microglial cells activated with beta-amyloid and interferon gamma
36. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
37. Alzheimer's disease: Its proteins and genes
38. Alzheimer's disease: Sharing of a unique cerebrovascular amyloid fibril protein
39. + channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity
40. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
41. Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation
42. Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways
43. 3H]glutamate binding
44. Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases
45. Long-term treatment of Alzheimer's disease with idebenone
46. Selkoe
47. Region-specific loss of glutamate innervation in Alzheimer's disease
48. Beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis
49. N-Methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against beta-amyloid neurotoxicity
50. 3)24)25-35 in rat nucleus basilis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic inervation
51. Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein
52. Assembly of A beta amyloid protofibrils: An in vitro model for a possible early event in Alzheimer's disease
53. Beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: Implications for Alzheimer's disease
54. +-dependent glutamate uptake in rat hippocampal astrocyte cultures
55. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
56. Nontoxic amyloid β peptide 1-42 suppresses acetylcholine synthesis
57. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease
58. Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats
59. Dysfunction of cholinergic and dopaminergic neuronal systems in β-Amyloid protein-infused rats
60. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
61. Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
62. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
63. β-Amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices
64. 2+-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons
65. Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line
66. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal
67. New therapeutic possibilities with low-affinity NMDA receptor antagonists
68. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
69. Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis
70. 2+]i in rat astrocytes
71. Nicotinic acetylcholine involvement in cognitive function in animals
72. 2+-sensitive channel in reconstituted lipid vesicles
73. β-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
74. Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease
75. 3H]TCP binding in Alzheimer's disease
76. 2+ homeostasis and cell death
77. Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease
78. Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor protein 670/671 mutation
79. Alzheimer's disease amyloid beta peptide 25-35 is localized in the membrane hydrocarbon core: X-ray diffraction analysis
80. Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
81. Cellular actions of β-amyloid precursor protein
82. Abeta25-35 induces rapid lysis of red blood cells: Contrast with Abeta1-42 and examination of underlying mechanisms
83. Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
84. Sigma (σ1) receptor agonists and neurosteroids attenuates (25-35) amyloid peptide-induced amnesia in mice through a common mechanism
85. Effects of exogenous β-amyloid peptide on retention for spatial learning
86. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
87. Activation of microglial cells by beta-amyloid protein and interferon-gamma
88. Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia
89. Alzheimer's disease animal models induced by continuous infusion of β-amyloid protein and anti-nerve growth factor antibody
90. Toxicity of β-amyloid protein: Neurochemical, histological and behavioral changes
91. Memory impairment and neuronal dysfunction induced by β-amyloid protein in rats
92. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein
93. Continuous infusion of β-amyloid protein into cerebral ventricle induces learning impairment and neuronal and morphological degeneration
94. Amyloid protein-induced Alzheimer's disease animal model
95. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide
96. Choline acetyltransferase: The structure, distribution and pathologic changes in the central nervous system
97. Alterations of nicotinic cholinergic receptor binding induced by beta-amyloid (1-42) in rats
98. Memory deficits and increased emotionality induced by β-amyloid (25-35) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus
99. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
100. The inhibitory effects of beta-amyloid on glutamate and glucose uptakes by cultured astrocytes
101. N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases
102. Amyloid β-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain
103. Amyloid β-peptides injection into the cholinergic nuclei: Morphological, neurochemical and behavioral effects
104. Beta-Amyloid (1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice
105. Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
106. Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro
107. Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: Relevance to Alzheimer's disease
108. A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid beta protein (A beta P) in phospholipid bilayer membranes
109. A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease
110. 2+-sensitive channel
111. Non-cholinergic neurotransmitter abnormalities in Alzheimer's disease
112. SB203580, the p38 mitogen-activated protein kinase inhibitor blocks the inhibitory effect of beta-amyloid on long-term potentiation in the rat hippocampus
113. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
114. Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease
115. Amyloid peptides are toxic via a common oxidative mechanism
116. Isolation
117. 3H]TCP binding sites in Alzheimer's disease brains
118. Widespread peroxynitrite-mediated damage in Alzheimer's disease
119. Intrahippocampal β-amyloid impairs win-shift radial maze performance in rats
120. Spatiotemporal expression of BDNF in the hippocampus induced by the continuous intracerebroventricular infusion of beta-amyloid in rats
121. Arrest of beta-amyloid fibril formation by a pentapeptide ligand
122. Amyloid β-peptide induces nitric oxide production in rat hippocampus: Association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors
123. Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment
124. Characterization of beta-amyloid peptide from human cerebrospinal fluid
125. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
126. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
127. Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions
128. β-Amyloid1-42 binds to α7 nicotinic acetylcholine receptor with high affinity
129. Amyloid peptide Aβ1-42 binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors
130. 2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture
131. Animal models of Alzheimer's disease and evaluation of anti-dementia drugs
132. Protective effects of idebenone and α-tocopherol on β-amyloid1-42 induced learning and memory deficits in rats: Implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo
133. Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
134. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
135. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
136. What's the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose
137. Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
138. Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia
139. Suppressive action produced by beta-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-D-aspartate receptor-independent: It's offset by (-)huperzine A
140. Fresh and nonfibrillar amyloid β protein (1-40) induces rapid cellular degeneration in aged human fibroblasts: Evidence for Aβ-protein channel-mediated cellular toxicity