Regulation of human α4/β2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways

Molecular Pharmacology

Volumn 52, Issue 3, 1997, Pages 524-534

  Gopalakrishnan, Murali ^a   Molinari, Eduardo J ^a   Sullivan, James P ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC G 418; HYGROMYCIN; MESSENGER RNA; NICOTINE; NICOTINIC RECEPTOR; STAUROSPORINE; ALKALOID; AZOCINE DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTISINE; ION CHANNEL; LIGAND; NICOTINIC RECEPTOR BLOCKING AGENT; PROTEIN KINASE C; QUINOLIZINE DERIVATIVE; TRITIUM;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONVULSION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; HUMAN; HUMAN CELL; LIGAND BINDING; MAMMAL; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; CELL CULTURE; DRUG EFFECT; GENETIC TRANSFECTION; KIDNEY; METABOLISM; PHYSIOLOGY; SECOND MESSENGER; ULTRASTRUCTURE; UPREGULATION;

ALKALOIDS; AZOCINES; BINDING SITES; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; ION CHANNELS; KIDNEY; LIGANDS; NICOTINE; NICOTINIC ANTAGONISTS; PROTEIN KINASE C; QUINOLIZINES; RECEPTORS, NICOTINIC; SECOND MESSENGER SYSTEMS; TRANSFECTION; TRITIUM; UP-REGULATION;

EID: 0030610921     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.3.524     Document Type: Article

References (40)

1. Albuquerque, E. X., M. Alkondon, E. F. R. Pereira, N. G. Castro, A. Schrattenholz, C. T. F. Barbosa, R. Bonfante-Cabarcas, Y. Aracava, H. M. Eisenberg, and A. Maelicke. Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function. J. Pharmacol. Exp. Ther. 280:1117-1136 (1997).
2. Role, L. W., and D. K. Berg. Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16:1077-1085 (1996).
3. Flores, C. M., S. W. Rogers, L. A. Pabreza, B. B. Wolfe, and K. J. Keller. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol. 41:31-37 (1992).
4. 125I]α-bungarotoxin. J. Neurosci. 5:1307-1315 (1985).
5. Marks, M. J., J. R. Pauly, S. D. Gross, E. S. Deneris, I. Hermans-Borgmeyer, S. F. Heinemann, and A. C. Collins. Nicotine binding and nicotinic receptor subunit mRNA after chronic nicotine treatment. J. Neurosci. 12:2765-2784 (1992).
6. Whiting, P., R. Schoepfer, J. Lindstrom, and T. Priestley. Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtypes stably expressed in mouse fibroblasts. Mol. Pharmacol. 40:463-472 (1991).
7. Gopalakrishnan, M., L. M. Monteggia, D. J. Anderson, E. J. Molinari, M. Piattoni-Kaplan, D. Donnelly-Roberts, S. P. Arneric, S. P., and J. P. Sullivan. Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine α4β2 receptor. J. Pharmacol. Exp. Ther. 276:289-297 (1996).
8. Picciotto, M. R., M. Zoli, C. Léna, A. Bessis, Y. Lallemand, N. Lenovère, P. Vincent, E. M. Pich, P. Brûlet and J.-P. Changeux. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature (Lond.) 374:65-67 (1995).
9. Wonnacott, S. The paradox of nicotine receptor up-regulation by nicotine. Trends Pharmacol. Sci. 11:216-219 (1990).
10. Nordberg, A. Neuroreceptor changes in Alzheimer's disease. Cerebrovasc. Brain Metab. Rev. 4:303-328 (1992).
11. Perry, E. K., C. M. Morris, J. A. Court, A. Cheng, A. F. Faibairn, I. G. Mckeith, D. Irving, A. Brown, and R. H. Perry. Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology. Neuroscience 64:385-395 (1995).
12. Schröder, H., E. Giacobini, A. Wevers, C. Birtsch, and U. Schutz. Nicotinic receptors in Alzheimer's disease, in Brian Imaging of Nicotine and Tobacco Smoking (E. F. Domino, ed.). NPP Books, Ann Arbor, MI, 73-93 (1995).
13. Beck, C., B. Moulard, O. Steinlein, M. Guipponi, L. Vallee, P. Montpied, M. Baldy-Moulnier, and A. Malafosse. A nonsense mutation in the α4 subunit of the nicotinic acetylcholine [CHRNA4] cosegregates with 20q-linked benign neonatal familial convulsions [EBNI]. Neurobiol. Dis. 1:95-99 (1994).
14. Steinlein, O. K., J. C. Mulley, P. Propping, R. H. Wallace, H. A. Philipps, G. R. Sutherland, I. E. Scheffer, and S. F. Berkovic. A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat. Genet. 11:201-203 (1995).
15. 3H]nicotine binding sites in human brain. J. Neurochem. 50:1243-1247 (1988).
16. Marks, M. J., S. R. Grady, and A. C. Collins. Down-regulation of nicotinic receptor function after chronic nicotine infusion. J. Pharmacol. Exp. Ther. 266:1268-1275 (1992).
17. Arneric, S. P., J. P. Sullivan, and M. Williams. Neuronal nicotinic acetylcholine receptors. Novel targets for CNS therapeutics, in Psychopharmacology: The Fourth Generation of Progress (F. E. Bloom and D. J. Kupfer, eds.). Raven Press, New York, 95-110 (1995).
18. Buisson, B., M. Gopalakrishnan, J. P. Sullivan, S. P. Arneric, and D. Bertrand. Human α4β2 neuronal nicotinic receptor in HEK-293 cells: a patch clamp study. J. Neurosci. 16:7880-7891 (1996).
19. Lukas, R. J., and M. J. Cullen. An isotopic ion efflux assay for the functional characterization of nicotinic acetylcholine receptors on clonal cell lines. Anal. Biochem. 175:212-218 (1988).
20. Lukas, R. J. Effects of chronic nicotinic ligand exposure on functional activity of nicotinic acetylcholine receptors expressed by cells of the PC12 rat pheochromocytoma or the TE671/RD human clonal line. J. Neurochem. 56:1134-1145 (1991).
21. Sullivan, J. P., D. Donnelly-Roberts, C. A. Briggs, D. J. Anderson, M. Gopalakrishnan, M. Piattoni-Kaplan, J. E. Campbell, D. G. McKenna, E. Molinari, A.-M. Hettinger, D. S. Garvey, J. T. Wasicak, M. W. Holladay, M. Williams, and S. P. Arneric. A-85380 (3-(2(S)-azetidinylmethoxy) pyridine): in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35:725-734 (1996).
22. 7 nicotinic acetylcholine receptor. Eur. J. Pharmacol. 290:237-246 (1995).
23. Peng, X., Y. Gerzanich, R. Anand, P. J. Whiting, and J. Lindstrom. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46:523-530 (1994).
24. Maelicke, A., H. Schröder, and A. Schrattenholz. Modulatory control by noncompetitive agonists of nicotinic cholinergic neurotransmission in the central nervous system. Semin. Neurosci. 7:103-114 (1995).
25. 2L dopamine receptors by agonists and antagonists in transfected HEK-293 cells. J. Pharmacol. Exp. Ther. 271:1574-1582 (1994).
26. Halverson, S. W., N. Jiang, and R. Malek. Regulation of nicotinic acetylcholine receptors on human neuroblastoma cells during differentiation. Biochem. Pharmacol. 50:1665-1671 (1995).
27. Bencherif, M., K. Fowler, R. J. Lukas, and P. M. Lippiello. Mechanisms of upregulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain. J. Pharmacol. Exp. Ther. 275:987-994 (1995).
28. Zhang, X., Z.-H. Gong, E. Hellstrom-Lindahl, and A. Nordberg. Regulation of alpha-4 beta-2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents. Neuroreport 6:313-317 (1995).
29. El-Bizri, H., and P. Clark. Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br. J. Pharmacol. 113:917-925 (1994).
30. Benowitz, N. L. Pharmacology of nicotine: addiction and therapeutics. Annu. Rev. Pharmacol. Toxicol. 36:597-613 (1996).
31. Donnelly-Roberts, D. L., S. P. Arneric, and J. P. Sullivan. Functional modulation of human 'ganglionic-like' neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists. Biochem. Biophys. Res. Commun. 213:657-662 (1995)
32. Green, W. N., A. F. Ross, and T. Claudio. cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms. Proc. Natl. Acad. Sci. USA 88:854-858 (1991).
33. Swope, S. L., S. J. Moss, C. D. Blackstone, and R. L. Huganir. Phosphorylation of ligand-gated ion channels: a possible mode of synaptic plasticity. FASEB J. 6:2514-2523 (1993).
34. Shyng, S. L., R. Xu, and M. M. Salpeter. Cyclic AMP stabilizes the degradation of original junctional acetylcholine receptors in denervated muscle. Neuron 6:469-475 (1991).
35. Margiotta, J. F., D. K. Berg, and V. E. Dionne. Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons. Proc. Natl. Acad. Sci. USA 84:8155-8159 (1987).
36. Vijayaraghavan, S., H. A. Schmid, S. W. Halverson, and D. K. Berg. Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor alpha-type subunit. J. Neurosci. 10:3255-3262 (1990).
37. Nakayama, H., H. Okuda, and T. Nakashima. Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro. Mol. Brain Res. 20:171-177 (1993).
38. Yang, X., and J. J. Buccafusco. Effect of chronic central treatment with the acetylcholine analog methylcarbamylcholine on cortical nicotinic receptors: correlation between receptor changes and behavioral function. J. Pharmacol. Exp. Ther. 271:651-659 (1994).
39. Coyle, J. T., D. L. Price, and M. R. Delong. Alzheimer's disease: a disorder of cholinergic innervation. Science (Washington D. C.) 219:1184-1190 (1983).
40. Maestrone, E., L. Lagostena, R. H. Henning, A. Den Hertog, and M. Nobile. Functional aspects of dexamethasone upregulated nicotinic acetylcholine receptors in C2C12 myotubes. Pharmacol. Res. 32:305-308 (1995).